Ethyl (methylthio)acetate
- CAS No.
- 4455-13-4
- Chemical Name:
- Ethyl (methylthio)acetate
- Synonyms
- FEMA 3835;ETHYL 2-(METHYLTHIO)ACETATE;Ethyl (methylthio)acetate;5-PHENYL-O-ANISIDINE, 98+%;Ethyl(Methylthio)acetate>Ethyl(methylthio)acetate,98%;Ethyl (methylsulfanyl)acetate;Ethyl (methylthio)acetate,95%;ethyl 2-methylsulfanylacetate;ETHYL ALPHA-(METHYLTHIO)ACETATE
- CBNumber:
- CB3335507
- Molecular Formula:
- C5H10O2S
- Molecular Weight:
- 134.2
- MDL Number:
- MFCD00009182
- MOL File:
- 4455-13-4.mol
- MSDS File:
- SDS
| Boiling point | 70-72 °C/25 mmHg (lit.) |
|---|---|
| Density | 1.043 g/mL at 25 °C (lit.) |
| refractive index |
n |
| FEMA | 3835 | ETHYL 2-(METHYLTHIO)ACETATE |
| FLAVIS Number | 12.122 | Ethyl 2-(methylthio)acetate |
| Flash point | 139 °F |
| storage temp. | 2-8°C |
| form | clear liquid |
| color | colorless |
| Odor | at 0.10 % in dipropylene glycol. sulfurous green fruity tropical |
| Odor Type | fruity |
| biological source | synthetic |
| Water Solubility | Miscible with alcohol. Immiscible with water. |
| Sensitive | Moisture Sensitive |
| JECFA Number | 475 |
| BRN | 1744999 |
| InChI | 1S/C5H10O2S/c1-3-7-5(6)4-8-2/h3-4H2,1-2H3 |
| InChIKey | MDIAKIHKBBNYHF-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CSC |
| LogP | 1.35 |
| Substances Added to Food (formerly EAFUS) | ETHYL 2-(METHYLTHIO)ACETATE |
| CAS DataBase Reference | 4455-13-4(CAS DataBase Reference) |
| FDA UNII | 6148QQN25T |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 3272 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Ethyl (methylthio)acetate price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W383503 | Ethyl (methylthio)acetate ≥98%, FG | 4455-13-4 | 1 each | $61.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 209716 | Ethyl (methylthio)acetate 98% | 4455-13-4 | 25g | $93.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | W383503 | Ethyl (methylthio)acetate ≥98%, FG | 4455-13-4 | 1 unit | $59.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | W383503 | Ethyl (methylthio)acetate ≥98%, FG | 4455-13-4 | sample | $59.8 | 2024-03-01 | Buy |
| TCI Chemical | M0897 | Ethyl (Methylthio)acetate >98.0%(GC) | 4455-13-4 | 5g | $19 | 2026-04-30 | Buy |
Ethyl (methylthio)acetate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to slightly yellow liquid
Chemical Properties
Ethyl-2-(methylthio)acetate has a fruity odor.
Occurrence
Reported found in melon, apple, pineapple, durian, yellow passion fruit and kiwifruit.
Uses
Ethyl (methylthio)acetate is used as an internal standard during the analytical determination of volatile sulfur compounds in port wines. Further, it is used as food flavors.
Uses
Ethyl (methylthio)acetate was used as internal standard during the analytical determination of volatile sulfur compounds in port wines.
Definition
ChEBI: Ethyl 2-(methylthio)acetate is a carboxylic ester.
Aroma threshold values
Detection: 250 ppb. Aroma characteristics at 1.0%: sweet, ethereal, rummy with a fruity sulfureous note, slightly vegetative cauliflower with a garlic nuance.
Taste threshold values
Taste characteristics at 1 to 2 ppm: sweet, fruity melon with an uplifting rummy undertone.
General Description
Natural occurrence: Apple and melon.
Biochem/physiol Actions
Taste at 1-2 ppm
Synthesis
64-17-5
2444-37-3
4455-13-4
Toluene (30 mL), ethanol (2.39 g, 169.59 mmol), and 2-(methylthio)acetic acid (15 g, 141.32 mmol) were sequentially added to a 100 mL round-bottomed flask at room temperature, followed by the addition of p-toluenesulfonic acid monohydrate (4.03 g, 21.20 mmol) as a catalyst. The reaction mixture was gently heated to reflux and the dehydration reaction was carried out for 3 to 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by addition of triethylamine (2.86 g, 28.26 mmol) to neutralize the acidic catalyst and silica gel for adsorption. After brief stirring, the silica gel was removed by filtration. The filtrate was distilled under reduced pressure to remove the solvent and finally purified by distillation to give ethyl (methylthio)acetate (14.81 g, 78% yield).
References
[1] Patent: US2010/324314, 2010, A1. Location in patent: Page/Page column 15-16
[2] Combinatorial Chemistry and High Throughput Screening, 2011, vol. 14, # 2, p. 132 - 137
Ethyl (methylthio)acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| jiliang chemicals | 21-62165282 | bidingchem@163.com | China | 1395 | 60 |
View Lastest Price from Ethyl (methylthio)acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Ethyl (methylthio)acetate
4455-13-4
|
1KG | 98%min | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | ETHYL (METHYLTHIO)ACETATE
4455-13-4
|
$1.10-35.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | ETHYL (METHYLTHIO)ACETATE
4455-13-4
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Ethyl (methylthio)acetate
4455-13-4
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- ETHYL (METHYLTHIO)ACETATE
4455-13-4
- $1.10-35.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- ETHYL (METHYLTHIO)ACETATE
4455-13-4
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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