1,2,3,4,5,6-Hexabromocyclohexane
- CAS No.
- 1837-91-8
- Chemical Name:
- 1,2,3,4,5,6-Hexabromocyclohexane
- Synonyms
- NSC 7908;JAK2 INHIBITOR II;BENZENE HEXABROMIDE;6-Hexabromocyclohexane;trans-α-Benzene hexabromide;1,2,3,4,5,6-Hexabromcyclohexan;1,2,3,4,5,6-hexabromo-cyclohexan;1,2,3,4,5,6-Hexabromocyclohexane;Cyclohexane, 1,2,3,4,5,6-hexabromo-;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
- CBNumber:
- CB3337703
- Molecular Formula:
- C6H6Br6
- Molecular Weight:
- 557.54
- MDL Number:
- MFCD00059127
- MOL File:
- 1837-91-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 218.0 to 223.0 °C |
|---|---|
| storage temp. | Store at RT |
| solubility | DMSO: soluble2mg/mL (clear solution, warmed) |
| form | powder |
| color | white to beige |
| InChI | 1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H |
| InChIKey | QFQZKISCBJKVHI-UHFFFAOYSA-N |
| SMILES | BrC1C(C(C(C(C1Br)Br)Br)Br)Br |
| CAS DataBase Reference | 1837-91-8(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-36-22 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
1,2,3,4,5,6-Hexabromocyclohexane price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 420132 | JAK2 Inhibitor II | 1837-91-8 | 25mg | $190 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0455 | 1,2,3,4,5,6-Hexabromocyclohexane ≥98% (HPLC) | 1837-91-8 | 50mg | $127 | 2022-05-15 | Buy |
| TCI Chemical | H0368 | 1,2,3,4,5,6-Hexabromocyclohexane min. 97.0 % | 1837-91-8 | 1G | $109 | 2021-12-16 | Buy |
| TCI Chemical | H0368 | 1,2,3,4,5,6-Hexabromocyclohexane | 1837-91-8 | 5g | $326 | 2021-12-16 | Buy |
| Usbiological | 254336 | 1,2,3,4,5,6-Hexabromocyclohexane Asreported | 1837-91-8 | 50mg | $380 | 2026-06-03 | Buy |
1,2,3,4,5,6-Hexabromocyclohexane Chemical Properties, Uses, Production
Uses
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.
Definition
ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.
Biological Activity
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.
storage
Room temperature
1,2,3,4,5,6-Hexabromocyclohexane Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,3,4,5,6-Hexabromocyclohexane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from 1,2,3,4,5,6-Hexabromocyclohexane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
1837-91-8
|
$1.00-101.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-07-27 | 1,2,3,4,5,6-Hexabromocyclohexane
1837-91-8
|
10g | TargetMol Chemicals Inc. |
-
- 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
1837-91-8
- $1.00-101.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1,2,3,4,5,6-Hexabromocyclohexane
1837-91-8
- TargetMol Chemicals Inc.
