Cbz-Cyclohexyl-L-glycine
- CAS No.
- 69901-75-3
- Chemical Name:
- Cbz-Cyclohexyl-L-glycine
- Synonyms
- Z-CHG-OH;Cbz-CycL;CBZ-CHG-OH;Z-L-Chg-OH;Cbz-L-CHG-OH;Z-CYCLOHEXYL-GLY-OH;Z-Cyclohexylglycine;Z-PHG(HEXAHYDRO)-OH;Z-L-CYCLOHEXYLGLYCINE;Z-L-cyclohexyl-Gly-OH
- CBNumber:
- CB3362020
- Molecular Formula:
- C16H21NO4
- Molecular Weight:
- 291.35
- MDL Number:
- MFCD00191083
- MOL File:
- 69901-75-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 111-114°C |
|---|---|
| Boiling point | 492.1±38.0 °C(Predicted) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.99±0.10(Predicted) |
| color | White |
| InChI | InChI=1/C16H21NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1,3-4,7-8,13-14H,2,5-6,9-11H2,(H,17,20)(H,18,19)/t14-/s3 |
| InChIKey | CUSYTUPJAYLNFQ-WDHUHKLTNA-N |
| SMILES | [C@H](C1CCCCC1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 |&1:0,r| |
| LogP | 1.7 at 25℃ and pH2.5 |
| CAS DataBase Reference | 69901-75-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373 | |||||||||
| Precautionary statements | P260-P314-P501 | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
Cbz-Cyclohexyl-L-glycine price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 268021 | Cbz-cyclohexyl-L-glycine | 69901-75-3 | 1g | $378 | 2026-06-03 | Buy |
| Usbiological | 268021 | Cbz-cyclohexyl-L-glycine | 69901-75-3 | 2g | $526 | 2026-06-03 | Buy |
| Usbiological | 268021 | Cbz-cyclohexyl-L-glycine | 69901-75-3 | 5g | $721 | 2026-06-03 | Buy |
| Usbiological | 268021 | Cbz-cyclohexyl-L-glycine | 69901-75-3 | 10g | $991 | 2026-06-03 | Buy |
| Usbiological | 268021 | Cbz-cyclohexyl-L-glycine | 69901-75-3 | 25g | $1380 | 2026-06-03 | Buy |
Cbz-Cyclohexyl-L-glycine Chemical Properties,Uses,Production
Chemical Properties
Cbz-Cyclohexyl-L-glycine is white to Off-White Solid
Uses
Cbz-Cyclohexyl-L-glycine is a gylicine derivative used in the preparation of peptides as inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4A protease.
Synthesis
14328-51-9
501-53-1
69901-75-3
General Steps: Step (1): 534 mL of deionized water and 60.9 mL of 20% aqueous sodium hydroxide were added to 60.0 g of L-(+)-2-cyclohexylglycine (L-CHG) and stirred until completely dissolved. Subsequently, activated carbon was added to the solution for decolorization and supplemented with 79 mL of deionized water. Under stirring, 65.1 g of benzyl chloroformate (Cbz-Cl) and 60.9 mL of 20% aqueous sodium hydroxide solution were added slowly and dropwise to introduce a benzyloxycarbonyl (Cbz) protecting group in the L-CHG molecule. Step (2): the reaction solution obtained in step (1) (total volume 865 mL) was added to deionized water and isopropyl alcohol (IPA) in the proportions shown in Table 1, respectively. Step (3): After the completion of step (2), 4.1 mL of hydrochloric acid was added to the reaction solution to carry out the neutralization reaction, and the precipitated crystals were subsequently separated by filtration. The crystals obtained by filtration were dried to finally obtain (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid (Cbz-L-CHG). The specific results for each experimental condition are detailed in Table 1.
References
[1] Patent: US2011/152573, 2011, A1. Location in patent: Page/Page column 3
Cbz-Cyclohexyl-L-glycine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 15366717810 | sales@thbiochem.com | China | 407 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Chiral Chemicals Inc. | 021-37285021 13472570865 | tym7xi@aliyun.com | China | 299 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from Cbz-Cyclohexyl-L-glycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Cbz-Chg-OH
69901-75-3
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-09-11 | Cbz-Cyclohexyl-L-glycine
69901-75-3
|
1KG | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-08 | Cbz-Cyclohexyl-L-glycine
69901-75-3
|
1kg | 97% | 100kg | Hangzhou ICH Biofarm Co., Ltd |
-
- Cbz-Chg-OH
69901-75-3
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Cbz-Cyclohexyl-L-glycine
69901-75-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Cbz-Cyclohexyl-L-glycine
69901-75-3
- 97%
- Hangzhou ICH Biofarm Co., Ltd
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