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4-Bromo-o-xylene

4-Bromo-o-xylene structure

CAS No.: 583-71-1

Chemical Name:: 4-Bromo-o-xylene

Synonyms: 4-BROMO-1,2-DIMETHYLBENZENE;o-Xylene, 4-bromo-;4-Bromoxylene, 98%;Medetomidine Impurity 1;Medetomidine Impurity 31;4-bromo-1,2-dimethyl-benzen;4-bromo-o-xylen;5-BROMO-O-XYLENE;4-BROMO-O-XYLENE;ρ-Bromo-o-xylene

CBNumber:: CB3363557

Molecular Formula:: C8H9Br

Molecular Weight:: 185.06

MDL Number:: MFCD00000086

MOL File:: 583-71-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:30:55

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4-Bromo-o-xylene Properties

Melting point	−12-−10 °C
Boiling point	215 °C (lit.)
Density	1.37 g/mL at 25 °C (lit.)
refractive index	n20/D 1.555(lit.)
Flash point	177 °F
storage temp.	Store below +30°C.
form	clear liquid
Specific Gravity	1.37
color	Colorless to Light yellow
Water Solubility	Not miscible in water.
BRN	2040354
InChI	1S/C8H9Br/c1-6-3-4-8(9)5-7(6)2/h3-5H,1-2H3
InChIKey	QOGHRLGTXVMRLM-UHFFFAOYSA-N
SMILES	Cc1ccc(Br)cc1C
CAS DataBase Reference	583-71-1(CAS DataBase Reference)
FDA UNII	X45692CHP5
NIST Chemistry Reference	Benzene, 4-bromo-1,2-dimethyl-(583-71-1)
EPA Substance Registry System	Benzene, 4-bromo-1,2-dimethyl- (583-71-1)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H331-H302-H315-H319-H335-H411-H227

Precautionary statements

P501-P273-P270-P261-P210-P271-P264-P280-P302+P352-P370+P378-P391-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P304+P340+P311-P403+P233-P403+P235-P405

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,N,Xi

Risk Statements

22-36/37/38-50/53

Safety Statements

26-60-61-24/25

RIDADR

UN 1701 6.1/PG 2

WGK Germany

RTECS

CY9020400

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

HS Code

29036990

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

4-Bromo-o-xylene price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B83800	4-Bromo-1,2-dimethylbenzene 70%	583-71-1	5g	$48.1	2023-06-20	Buy
Sigma-Aldrich	B83800	4-Bromo-1,2-dimethylbenzene 70%	583-71-1	100g	$311	2023-06-20	Buy
TCI Chemical	B1346	4-Bromo-o-xylene (contains 3-Bromo-o-xylene)	583-71-1	25G	$37	2026-04-30	Buy
TCI Chemical	B1346	4-Bromo-o-xylene (contains 3-Bromo-o-xylene)	583-71-1	500G	$409	2022-04-27	Buy
Strem Chemicals	06-0125	1-Bromo-3,4-dimethylbenzene, min. 97% min.97%	583-71-1	5g	$40	2026-04-30	Buy

Product number	Packaging	Price	Buy
B83800	5g	$48.1	Buy
B83800	100g	$311	Buy
B1346	25G	$37	Buy
B1346	500G	$409	Buy
06-0125	5g	$40	Buy

4-Bromo-o-xylene Chemical Properties, Uses, Production

Chemical Properties

Clear colourless to light yellow liquid

Uses

4-Bromo-o-xylene is used as synthetic organic materials and soluble polyimide resin intermediates.

Synthesis

A method for the preparation of 4-bromo-1,2-xylene, the method uses o-xylene as raw material, in the presence of dichloromethane solvent and catalyst, dropwise addition of bromine at a temperature of -60 to -20 , o-xylene and bromine molar ratio of 1:1, after the dropwise addition is completed, hold the temperature to carry out the reaction, and then slowly raise the temperature to 10-20 , to remove the dissolved hydrogen bromide in the reaction solution, add saturated aqueous solution of sodium sulfite , stirring for 30 minutes, the product containing dichloromethane was recovered by layering, and then washed with 5% dilute alkali solution to PH = 8-9, and finally washed with water to neutral, to obtain colorless or light yellow 4-bromo-1,2-xylene crude product, distillation under atmospheric pressure to recover solvent dichloromethane, and then distillation under reduced pressure to obtain 4-bromo-1,2-xylene product, said catalyst is a mixture of ferric chloride and quaternary ammonium salt, and the catalyst is a mixture of ferric chloride and quaternary ammonium salt. The quaternary ammonium salt is for example: tetrabutyl ammonium chloride, tetrabutyl ammonium bromide, tetrapropyl ammonium bromide, methyltrioctyl ammonium chloride, benzyltriethylammonium chloride, and the mass ratio of ferric trichloride and the quaternary ammonium salt is 4-5:1. The content of the obtained 4-bromo-1,2-xylene is increased to 85-93%, and at the same time, the content of the byproduct is reduced, and the yield of the product is increased to 95%. Duration of bromine addition: 3-4 h. Holding time of reaction: 2 h. Temperature of alkaline washing: room temperature.

4-Bromo-o-xylene synthesis

Synthesis of 4-Bromo-o-xylene from o-Xylene

4-Bromo-o-xylene Preparation Products And Raw materials

Raw materials

o-Xylene Hydrogen bromide Bromine

Preparation Products

5-Bromoisoindoline 2,4-Dimethylbromobenzene 1,2-Dimethyl-4-fluorobenzene 2,2,3',4'-Tetramethylpropiophenone 2 4-Dimethylphenylmagnesium bromide 0.&

4-Bromo-o-xylene Suppliers

Global Suppliers ( 216)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Shanghai Kaisai Chemical Co., Ltd	021-33516722 13701817765	kaisaichem@163.com	China	4604	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing dtftchem Technology Co., Ltd.	010-60275820 13031183356	elainezt@sina.com	China	1386	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Shanghai Kaisai Chemical Co., Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Beijing dtftchem Technology Co., Ltd.	62
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from 4-Bromo-o-xylene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4-Bromo-o-xylene 583-71-1		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2019-07-06	4-Bromo-o-xylene 583-71-1	$1.00	1KG	95%	500KG	Career Henan Chemical Co
2019-07-06	4-Bromo-o-xylene 583-71-1	$1.00	1KG	40%-99%	1000kg	Career Henan Chemical Co

4-Bromo-o-xylene
583-71-1
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-o-xylene
583-71-1
$1.00
95%
Career Henan Chemical Co

4-Bromo-o-xylene
583-71-1
$1.00
40%-99%
Career Henan Chemical Co

4-Bromo-o-xylene Spectrum

4-Bromo-o-xylene(583-71-1)MS 4-Bromo-o-xylene(583-71-1)¹³CNMR 4-Bromo-o-xylene(583-71-1)IR1 4-Bromo-o-xylene(583-71-1)Raman

583-71-1 (4-Bromo-o-xylene) Related Search:

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o-Xylene Xylene 3-Bromoanisole 2,3-Dimethylbenzaldehyde 5-[1-(2,3-DiMethylphenyl)ethenyl]iMidazole

2-(1-chloroethyl)-1,4-dimethylbenzene Medetomidine Impurity 54 3-Methylbenzyl bromide

1of4

o-Xylene, 4-bromo- 4-Bromo-ortho-xylene 4-bromo-o-xylen B**4-Bromo-o-xylene 4-Bromo-O-Xylene97% 4-Bromo-o-xylene, remainder 3-bromo-o-xylene, 75% 4-BROMO-O-XYLENE / 1-BROMO3,4-DIMETHYLBENZENE 4-Bromo-1,2-dimethylbenzene~3,4-Dimethylbromobenzene 3.4-DIMETHYLBROMOBENZENE 99% 4-Bromo-o-xylene, 75%, remainder 3-bromo-o-xylene 4-Bromoxylene,98% 3,4-DIMETHYLBROMOBENZENE 1-BROMO-3,4-DIMETHYLBENZENE 5-BROMO-O-XYLENE 4-Bromo-1,2-xylene 4-BROMO-O-XYLENE ρ-Bromo-o-xylene 4-Bromo-o-xylene (contains 3-Bromo-o-xylene) 4-bromo -1,2-dimethybenzene Medetomidine Impurity 31 4-Bromo-1,2-dimethyL 3,4-dimethylphenylbromide 3,4-Xylyl bromide 3,4-xylylbromide Benzene, 4-bromo-1,2-dimethyl- 3,4- twodiMethylbroMobenzene Medetomidine Impurity 1 4-Bromo-o-xylene for synthesis 4-Bromo-o-xylene, 75%, contains 3-Bromo-o-xylene Medetomidine Impurity 45 4-Bromo-o-xylene (contains 3-Bromo-o-xylene)> 4-Bromo-o-xylene ISO 9001：2015 REACH 4-Bromo-1,2-dimethylbenzene, 98% 4-bromo-1,2-dimethyl-benzen 4-BROMO-1,2-DIMETHYLBENZENE 4-Bromoxylene, 98% 583-71-1 CH32C6H3Br Halogenated Hydrocarbons Organic Building Blocks ARYL HALIDE Building Blocks C8 Aryl Halogen toluene Benzene derivates Bromine Compounds Aromatic Halides (substituted) K00001