6(5H)-Phenanthridone
- CAS No.
- 1015-89-0
- Chemical Name:
- 6(5H)-Phenanthridone
- Synonyms
- phenanthridin-6(5H)-one;PHENANTHRIDINONE;6(5H)-Phenantridinone;PJ 97A;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenantridone;PHENANTHRIDONE
- CBNumber:
- CB3386736
- Molecular Formula:
- C13H9NO
- Molecular Weight:
- 195.22
- MDL Number:
- MFCD00004988
- MOL File:
- 1015-89-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 290-292 °C(lit.) |
|---|---|
| Boiling point | 435 °C |
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL |
| pka | 13.27±0.20(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Water Solubility | Soluble in DMSO (5 mg/ml). Insoluble in water. |
| λmax | 338nm(EtOH)(lit.) |
| BRN | 140641 |
| InChI | InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15) |
| InChIKey | RZFVLEJOHSLEFR-UHFFFAOYSA-N |
| SMILES | C1=C2C(NC(=O)C3=C2C=CC=C3)=CC=C1 |
| CAS DataBase Reference | 1015-89-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | AVQ13AUB5J |
| NIST Chemistry Reference | 6(5H)-phenanthridinone(1015-89-0) |
| EPA Substance Registry System | 6-Phenanthridinone (1015-89-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SG0370000 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
6(5H)-Phenanthridone price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 299634 | 6-(5H)-Phenanthridinone technical grade | 1015-89-0 | 1g | $70.6 | 2026-04-30 | Buy |
| TCI Chemical | P1998 | 6(5H)-Phenanthridinone >98.0%(HPLC)(N) | 1015-89-0 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | P1998 | 6(5H)-Phenanthridinone >98.0%(HPLC)(N) | 1015-89-0 | 5g | $85 | 2026-04-30 | Buy |
| Cayman Chemical | 28730 | 6(5H)-Phenanthridinone ≥98% | 1015-89-0 | 1mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 28730 | 6(5H)-Phenanthridinone ≥98% | 1015-89-0 | 5mg | $132 | 2026-04-30 | Buy |
6(5H)-Phenanthridone Chemical Properties,Uses,Production
Uses
6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.
Uses
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Definition
ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Synthesis Reference(s)
Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027
Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054
General Description
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
6(5H)-Phenanthridone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou shuicao chemical Nes material Industry?Co.,Ltd. | 0519-86609972; 13861152845 | 987349505@qq.com | China | 86 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ChangShu Haitian Fine Chemicals Co.,Ltd | 13913622609 | 974295387@qq.com | China | 192 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
View Lastest Price from 6(5H)-Phenanthridone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 6(5H)-Phenanthridone
1015-89-0
|
$44.00-593.00 | 25g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-09-02 | Phenanthridin-6(5H)-one
1015-89-0
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 6(5H)-Phenanthridone
1015-89-0
|
$10.70 | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 6(5H)-Phenanthridone
1015-89-0
- $44.00-593.00
- 0.98
- Shanghai UCHEM Inc.
-
- Phenanthridin-6(5H)-one
1015-89-0
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 6(5H)-Phenanthridone
1015-89-0
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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