4-Chlorobenzyl cyanide
- CAS No.
- 140-53-4
- Chemical Name:
- 4-Chlorobenzyl cyanide
- Synonyms
- Para chloro benzyl cyanide;2-(4-Chlorophenyl)acetonitrile;(4-CHLOROPHENYL)ACETONITRILE;P-CHLOROBENZYL CYANIDE;PCCN;P-CHLOROPHENYLACETONITRILE;4-Chlorobenzeneacetonitrile;Pyrimethamine EP Impurity C;4-Chlorobenzyl cyanide/4-Chlorophenylacetonitrile;PCNN
- CBNumber:
- CB3390535
- Molecular Formula:
- C8H6ClN
- Molecular Weight:
- 151.59
- MDL Number:
- MFCD00001918
- MOL File:
- 140-53-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (4-Chlorophenyl)acetonitrile 96% | C28006 | 100g | $55.3 |
| (4-Chlorophenyl)acetonitrile 96% | C28006 | 500g | $122 |
| 4-Chlorobenzyl Cyanide >98.0%(GC) | C0585 | 25g | $17 |
| 4-Chlorobenzyl Cyanide >98.0%(GC) | C0585 | 500g | $97 |
| 4-Chlorobenzyl cyanide Asreported | 269381 | 250g | $386 |
| More product size | |||
| Melting point | 25-28 °C(lit.) |
|---|---|
| Boiling point | 265-267 °C(lit.) |
| Density | 1.19 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.3g/l |
| form | Liquid After Melting |
| color | Clear colorless to yellow |
| BRN | 971171 |
| Exposure limits | NIOSH: IDLH 25 mg/m3 |
| InChI | 1S/C8H6ClN/c9-8-3-1-7(2-4-8)5-6-10/h1-4H,5H2 |
| InChIKey | IVYMIRMKXZAHRV-UHFFFAOYSA-N |
| SMILES | Clc1ccc(CC#N)cc1 |
| CAS DataBase Reference | 140-53-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | K2K7AKZ2Z7 |
| NIST Chemistry Reference | Benzeneacetonitrile, 4-chloro-(140-53-4) |
| EPA Substance Registry System | Benzeneacetonitrile, 4-chloro- (140-53-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 23/24/25-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-28B | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AL8250000 | |||||||||
| Hazard Note | Irritant/Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29269095 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Chlorobenzyl cyanide price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C28006 | (4-Chlorophenyl)acetonitrile 96% | 140-53-4 | 100g | $55.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | C28006 | (4-Chlorophenyl)acetonitrile 96% | 140-53-4 | 500g | $122 | 2023-06-20 | Buy |
| TCI Chemical | C0585 | 4-Chlorobenzyl Cyanide >98.0%(GC) | 140-53-4 | 25g | $17 | 2026-04-30 | Buy |
| TCI Chemical | C0585 | 4-Chlorobenzyl Cyanide >98.0%(GC) | 140-53-4 | 500g | $97 | 2026-04-30 | Buy |
| Usbiological | 269381 | 4-Chlorobenzyl cyanide Asreported | 140-53-4 | 250g | $386 | 2026-06-03 | Buy |
4-Chlorobenzyl cyanide Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellowish liquid after melting. Soluble in acetone and ethanol.
Uses
4-Chlorobenzyl cyanide is an intermediate for the preparation of 3-methyl-2-(4-chlorophenyl)butyric acid, which can be used to prepare pyrethroid insecticides such as fenvalerate and deltamethrin, and can be used in medicine Industrial preparation of pyrimethamine.
Preparation
4-Chlorobenzyl cyanide is obtained by the reaction of 4-Chlorobenzyl chloride with sodium cyanide. Add 4-Chlorobenzyl chloride and Benzyldodecyldimethylammonium bromide into the reaction pot, heat to 100°C, slowly add sodium cyanide aqueous solution, and react at 100-104°C for 5h (add sodium cyanide for 3h, keep warm for 2h). Then add water to dissolve sodium chloride, and separate the water layer to obtain the crude benzyl chloride cyanide, which is distilled under reduced pressure to collect 160 (2.66kPa) fractions to obtain the finished product of 4-Chlorobenzyl cyanide. The yield is above 81%.
Definition
ChEBI: 4-Chlorobenzyl cyanide is a nitrile that is acetonitrile in which one of the hydrogens has been replaced by a p-chlorophenyl group. It is a member of monochlorobenzenes and a nitrile. It derives from an acetonitrile.
Synthesis
4251-65-4
140-53-4
Microwave radiation synthesis procedure: p-chlorophenylacetaldehyde (0.106 g, 1 mmol), hydroxylamine hydrochloride (0.083 g, 1.2 mmol) and catalyst (15 mol%) were mixed in a microwave reactor and the reaction was carried out by radiation at 140°C for 10 min. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was cooled to room temperature. The products were extracted using ethyl acetate (EtOAc). Subsequently, EtOAc was removed by rotary evaporator to obtain a solid product. The solid product was further purified by silica gel column chromatography. Finally, the purified p-chlorobenzeneacetonitrile was confirmed by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR) for characterization.
References
[1] Synthesis (Germany), 2013, vol. 45, # 23, p. 3295 - 3299
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 16, p. 2379 - 2384
4-Chlorobenzyl cyanide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
View Lastest Price from 4-Chlorobenzyl cyanide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-22 | 4-Chlorobenzyl cyanide
140-53-4
|
1KG | 99% | 1000mt/year | Jinan Finer Chemical Co., Ltd | ||
 |
2026-07-15 | 4-Chlorobenzyl cyanide
140-53-4
|
$7610.00 | 1T | 98% | 1-10mt | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-05-28 | 4-Chlorobenzyl cyanide
140-53-4
|
$9.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 4-Chlorobenzyl cyanide
140-53-4
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 4-Chlorobenzyl cyanide
140-53-4
- $7610.00
- 98%
- Baoji Guokang Healthchem Co., Ltd.
-
- 4-Chlorobenzyl cyanide
140-53-4
- $9.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
