4-Chlorophenoxyacetic acid
- CAS No.
- 122-88-3
- Chemical Name:
- 4-Chlorophenoxyacetic acid
- Synonyms
- 4-CPA;IUPAC;4-CP;P-CHLOROPHENOXYACETIC ACID;CPA;bi12;4CPAe;nsc8769;nsc-8769;Sure-Set
- CBNumber:
- CB7189313
- Molecular Formula:
- C8H7ClO3
- Molecular Weight:
- 186.59
- MDL Number:
- MFCD00004305
- MOL File:
- 122-88-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 157-159 °C |
|---|---|
| Boiling point | 266.91°C (rough estimate) |
| Density | 1.3245 (rough estimate) |
| refractive index | 1.5250 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 957mg/l |
| form | crystalline |
| pka | pK1: 3.10 (25°C) |
| color | White to light beige |
| Water Solubility | 848mg/L(25 ºC) |
| BRN | 1211804 |
| Henry's Law Constant | 1.0×105 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| Major Application |
agriculture environmental |
| InChI | 1S/C8H7ClO3/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H,10,11) |
| InChIKey | SODPIMGUZLOIPE-UHFFFAOYSA-N |
| SMILES | OC(=O)COc1ccc(Cl)cc1 |
| LogP | 2.250 |
| CAS DataBase Reference | 122-88-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4EMM3U5P3K |
| NIST Chemistry Reference | 4-Chlorophenoxyacetic acid(122-88-3) |
| EPA Substance Registry System | 4-Chlorophenoxyacetic acid (122-88-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.72 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-R22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AG0175000 | |||||||||
| F | 21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Hazardous Substances Data | 122-88-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: 850mg/kg | |||||||||
| NFPA 704 |
|
4-Chlorophenoxyacetic acid price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 25890 | 4-Chlorophenoxyacetic acid ≥98.0% (T) | 122-88-3 | 250g | $91.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 25890 | 4-Chlorophenoxyacetic acid ≥98.0% (T) | 122-88-3 | 1kg | $326 | 2026-04-30 | Buy |
| TCI Chemical | C0250 | 4-Chlorophenoxyacetic Acid | 122-88-3 | 25G | $32 | 2026-04-30 | Buy |
| TCI Chemical | C0250 | 4-Chlorophenoxyacetic Acid | 122-88-3 | 500G | $179 | 2026-04-30 | Buy |
| Biosynth | FC01864 | 4-Chlorophenoxyacetic acid | 122-88-3 | 1000g | $240 | 2026-06-04 | Buy |
4-Chlorophenoxyacetic acid Chemical Properties,Uses,Production
Description
4-CPA is a plant growth regulator. It is moderately soluble in water and is quite volatile. Little is known about its persistence in soil and aquatic systems. It is moderately toxic to mammals and has a high potential for bioaccumulation. It is also a recognised irritant. It is moderately toxic to birds, honeybees and most aquatic organisms. However, it has a relatively low toxicity to fish.
Chemical Properties
white to light beige powder
Uses
2-(4-Chlorophenoxy)acetic Acid is used in the synthesis of a new class of hypoxia-inducible factor-1 inhibitors.
Uses
4-chlorophenoxy acetic acid (4-CPA), a chlorine derivative of phenoxyacetic acid (PA), is a plant growth regulator used as a herbicide.
Production Methods
The production of (4-chlorophenoxy)acetic acid involves a multi-step organic synthesis starting with chlorinated aromatic precursors. Typically, 4-chlorophenol is reacted with chloroacetic acid or its derivatives under controlled conditions to form the ether linkage, yielding the phenoxyacetic acid structure. The reaction is often carried out in the presence of a base (such as sodium hydroxide) and a solvent like ethanol or tetrahydrofuran, followed by acidification to isolate the product.
Definition
ChEBI: A chlorophenoxyacetic acid that is phenoxyacetic acid carrying a chloro substituent at position 4.
General Description
4-Chlorophenoxyacetic acid is a herbicide. Degradation of 4-chlorophenoxyacetic acid in aqueous medium by advanced electrochemical oxidation processes, using an undivided cell containing a Pt anode has been reported.
Hazard
Moderately toxic; mutagen.
Biochem/physiol Actions
4-Chlorophenoxyacetic acid is a synthetic auxin, that is used to induce parthenocarpic ovary growth on flowers of wild type plants.
Mechanism of action
Auxin-transport inhibitor. Absorbed by tissue and translocated to roots
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of Cl-.
Purification Methods
Crystallise the acid from EtOH. It is a plant growth substance and a herbicide. [Beilstein 6 IV 845.]
Pesticide Type
Plant Growth Regulator; Herbicide
4-Chlorophenoxyacetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengtian Fine Chemical Co., Ltd | 18164098996 | 3554657675@qq.com | China | 6337 | 58 |
| Hubei Zhuosheng New Material Technology Co., Ltd | 18971238634 | 2189484023@qq.com | China | 497 | 58 |
| Hubei Bolan Chemical Co., LTD | 13297969979 13297969979 | nxiaoshida2@163.com | China | 711 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from 4-Chlorophenoxyacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 4-Chlorophenoxyacetic acid
122-88-3
|
$48.00 | 1kg | 0.99 | 100kg | Shanghai UCHEM Inc. | |
 |
2026-09-11 | 4-Chlorophenoxyacetic acid
122-88-3
|
1KG | 98.0% | 1000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-03-20 | 4-Chlorophenoxyacetic acid
122-88-3
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Chlorophenoxyacetic acid
122-88-3
- $48.00
- 0.99
- Shanghai UCHEM Inc.
-
- 4-Chlorophenoxyacetic acid
122-88-3
- $0.00
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Chlorophenoxyacetic acid
122-88-3
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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