2,4,5-Trimethoxybenzoic acid
- CAS No.
- 490-64-2
- Chemical Name:
- 2,4,5-Trimethoxybenzoic acid
- Synonyms
- ASARONIC ACID;AKOS BBS-00003744;RARECHEM AL BO 0322;TriMethoxybenzoic aci;2,4,5-Trimethoxybenzoic;2,4,5-trimethoxybenzoate;2,4,5-Trimethoxybenzoesur;2,4,5-trimethoxy-benzoicaci;2,4,5-TRIMETHOXYBENZOIC ACID;Benzoic acid, 2,4,5-trimethoxy-
- CBNumber:
- CB3390777
- Molecular Formula:
- C10H12O5
- Molecular Weight:
- 212.2
- MDL Number:
- MFCD00002435
- MOL File:
- 490-64-2.mol
- MSDS File:
- SDS
| Melting point | 143-145 °C (lit.) |
|---|---|
| Boiling point | 300 °C |
| Density | 1.3006 (rough estimate) |
| refractive index | 1.5140 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 4.24±0.10(Predicted) |
| color | White to Off-White |
| Water Solubility | SOLUBLE |
| λmax | 226nm(EtOH)(lit.) |
| InChI | InChI=1S/C10H12O5/c1-13-7-5-9(15-3)8(14-2)4-6(7)10(11)12/h4-5H,1-3H3,(H,11,12) |
| InChIKey | KVZUCOGWKYOPID-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(OC)=C(OC)C=C1OC |
| CAS DataBase Reference | 490-64-2(CAS DataBase Reference) |
| FDA UNII | 9WDU77RBH9 |
| EPA Substance Registry System | Benzoic acid, 2,4,5-trimethoxy- (490-64-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2,4,5-Trimethoxybenzoic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 138894 | 2,4,5-Trimethoxybenzoic acid 99% | 490-64-2 | 10g | $28.9 | 2023-06-20 | Buy |
| TCI Chemical | T2627 | 2,4,5-Trimethoxybenzoic Acid >98.0%(GC)(T) | 490-64-2 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | T2627 | 2,4,5-Trimethoxybenzoic Acid >98.0%(GC)(T) | 490-64-2 | 25g | $54 | 2026-04-30 | Buy |
| Usbiological | 290848 | 2,4,5-Trimethoxybenzoic acid Asreported | 490-64-2 | 50g | $239 | 2026-06-03 | Buy |
| Usbiological | 290848 | 2,4,5-Trimethoxybenzoic acid Asreported | 490-64-2 | 100g | $355 | 2026-06-03 | Buy |
2,4,5-Trimethoxybenzoic acid Chemical Properties,Uses,Production
Preparation
The preparation steps of the pharmaceutical intermediate 2,4,5-trimethoxybenzoic acid are as follows: Step 1: Add 4.42g of 1,2,4-trimethoxybenzene and 10ml of DMF to a reaction flask. Heat in an ice-water bath at 10℃. Add a DMF solution containing 1.47g of phosphorus oxychloride dropwise. After the addition is complete, heat the mixture to 60℃ and stir for 1 hour. Step 2: Control the reaction via TLC. If the reaction is complete, pour the reaction solution into 30ml of cold water. Add 30% potassium hydroxide solution to adjust the pH to 7. Cool to 5℃ and allow crystallization for 30 minutes. Filter and wash to obtain 2,4,5-trimethoxybenzaldehyde. Step 3: Add 5g of 2,4,5-trimethoxybenzaldehyde and 1.5g of ZnO to a reaction flask. rO2/MCM-41 nanocatalyst, 10 mol% silver nitrate, and 50 ml acetonitrile were added dropwise with 8.7 g of 30% hydrogen peroxide solution at room temperature. After the addition was complete, the reaction system was heated to 50°C and reacted for 3 h. Step 4: After the reaction was complete, the reaction solution was added to 50 ml of 10% cold alkaline solution and stirred. The insoluble substances were filtered out, and the pH of the filtrate was adjusted to 3.5 with concentrated sulfuric acid. Extraction was performed with ethyl acetate (2 × 50 ml), and the organic phases were combined. The mixture was washed once with saturated sodium chloride, dried over magnesium sulfate, concentrated, and recrystallized from benzene and petroleum ether to give a white crystalline product, 2,4,5-trimethoxybenzoic acid.
Chemical Properties
white fine crystalline powder
Uses
2,4,5-Trimethoxybenzoic Acid can be used to alleviate, treat, and prevent inflammatory diseases.
Uses
2,4,5-Trimethoxybenzoic acid was used as internal standard during the determination of the various types of hydroxyl groups present in lignins.
Definition
ChEBI: 2,4,5-Trimethoxybenzoic acid is a methoxybenzoic acid.
2,4,5-Trimethoxybenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| Shanghai Qiao Chemical Science Co., Ltd | 021-58892003 | info@qiaochem.com | China | 6065 | 65 |
| NANJING CHEMFIRST CO.,LTD. | 025-87780427 15850602248 | info@chemfs.com | China | 16 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from 2,4,5-Trimethoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2,4,5-Trimethoxybenzoic acid
490-64-2
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-30 | 2,4,5-Trimethoxybenzoic acid
490-64-2
|
$150.00 | 1KG | 98% | 2000kg | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2026-06-30 | 2,4,5-Trimethoxybenzoic acid
490-64-2
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,4,5-Trimethoxybenzoic acid
490-64-2
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,4,5-Trimethoxybenzoic acid
490-64-2
- $150.00
- 98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- 2,4,5-Trimethoxybenzoic acid
490-64-2
- 98
- Shaanxi Dideu New Materials Co. Ltd
