3-Fluoro-5-iodoaniline
- CAS No.
- 660-49-1
- Chemical Name:
- 3-Fluoro-5-iodoaniline
- Synonyms
- 5-FLUORO-3-IODOANILINE;3-Fluoro-5-iodoaniline;3-Fluoro-5-iodoaniline,96%;3-FLUORO-5-IODO-PHENYLAMINE;Benzenamine, 3-fluoro-5-iodo-
- CBNumber:
- CB3398647
- Molecular Formula:
- C6H5FIN
- Molecular Weight:
- 237.01
- MDL Number:
- MFCD04116466
- MOL File:
- 660-49-1.mol
- MSDS File:
- SDS
| Boiling point | 279.5±25.0 °C(Predicted) |
|---|---|
| Density | 2.008±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 2.62±0.10(Predicted) |
| Appearance | Brown to reddish brown Liquid |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 660-49-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2921420090 | |||||||||
| NFPA 704 |
|
3-Fluoro-5-iodoaniline price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC5888 | 3-Fluoro-5-iodoaniline 97% | 660-49-1 | 5g | $385 | 2026-06-04 | Buy |
| Activate Scientific | AS38610 | 3-Fluoro-5-iodoaniline 97% | 660-49-1 | 1g | $44 | 2026-06-04 | Buy |
| Activate Scientific | AS38610 | 3-Fluoro-5-iodoaniline 97% | 660-49-1 | 5g | $161 | 2026-06-04 | Buy |
| Activate Scientific | AS38610 | 3-Fluoro-5-iodoaniline 97% | 660-49-1 | 25g | $511 | 2026-06-04 | Buy |
| Activate Scientific | AS38610 | 3-Fluoro-5-iodoaniline 97% | 660-49-1 | 100g | $1658 | 2026-06-04 | Buy |
3-Fluoro-5-iodoaniline Chemical Properties, Uses, Production
Synthesis
3819-88-3
660-49-1
1. A suspension of 1-fluoro-3-iodo-5-nitrobenzene (0.5 g, 1.87 mmol) with SnCl2-2H2O (1.5 g, 6.64 mmol) in ethanol (10 mL) was heated to reflux for 1.5 hours. After completion of the reaction, the solvent was removed under reduced pressure and the crude product was diluted with ether and washed sequentially with 4N NaOH solution and saturated saline. The ether layer was separated, dried with anhydrous Na2SO4, filtered and concentrated to give the amine compound as a solid (0.4 g, 91% yield). The crude product can be used directly in the next step of the reaction. 2. A mixture of amine (0.4 g, 1.69 mmol), iodomethane (0.719 g, 5 mmol) and potassium carbonate (0.46 g, 3.38 mmol) obtained above in N,N-dimethylformamide (DMF; 10 mL) was stirred at room temperature for 48 hours. After completion of the reaction, water (10 mL) was added and extracted three times with ether. The organic extracts were combined, washed sequentially with water and saturated saline, dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purified by column chromatography to afford 3-fluoro-5-iodo-N,N-dimethylaniline (VMY-2-119) as liquid (0.23 g, 52% yield). 1H NMR (399 MHz, CDCl3) δ: 6.69-6.63 (m, 2H), 6.22 (dt, J = 12.5, 2.3 Hz, 1H), 2.83 (s, 6H). 13C NMR (100 MHz, CDCl3) δ: 163.33 (d, JF-C = 245 Hz), 152.49 (d, J = 11 Hz), 116.91 (d, J = 2.4 Hz), 112.12 (d, J = 24 Hz), 98.73 (d, J = 26 Hz), 94.24 (d, J = 11 Hz), 40.21 (s, 3H). 40.21 (s, 3H).
References
[1] Patent: WO2013/71067, 2013, A1. Location in patent: Page/Page column 42-43
[2] Chemical and Pharmaceutical Bulletin, 2005, vol. 53, # 2, p. 153 - 163
[3] Journal of Organic Chemistry, 1960, vol. 25, p. 1342 - 1348
[4] Patent: EP1382603, 2004, A1. Location in patent: Page 170
[5] Patent: US6821980, 2004, B1. Location in patent: Page column 40-41
3-Fluoro-5-iodoaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 3-Fluoro-5-iodoaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3-FLUORO-5-IODOANILINE
660-49-1
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2020-03-08 | 3-FLUORO-5-IODOANILINE
660-49-1
|
$3.00 | 1KG | 99%min | 200kg | Career Henan Chemical Co |
-
- 3-FLUORO-5-IODOANILINE
660-49-1
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-FLUORO-5-IODOANILINE
660-49-1
- $3.00
- 99%min
- Career Henan Chemical Co
