1-Fluoro-3-iodobenzene
- CAS No.
- 1121-86-4
- Chemical Name:
- 1-Fluoro-3-iodobenzene
- Synonyms
- 3-FLUOROIODOBENZENE;m-Fluorobenzene;3-Fluoriodobenzol;M-FLUOROIODOBENZENE;3-Iodofluorobenzene;m-Iodofluorobenzene;3- Fluoriodobenzene;1-fluoro-3-iodo-benzen;3-Fluoro-1-iodobenzene;1-Iodo-3-fluorobenzene
- CBNumber:
- CB0284196
- Molecular Formula:
- C6H4FI
- Molecular Weight:
- 222
- MDL Number:
- MFCD00001044
- MOL File:
- 1121-86-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -42°C |
|---|---|
| Boiling point | 77-78 °C/19 mmHg (lit.) |
| Density | 1.89 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 153 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear yellow or pink |
| Specific Gravity | 1.890 |
| Sensitive | Light Sensitive |
| BRN | 2039305 |
| InChI | 1S/C6H4FI/c7-5-2-1-3-6(8)4-5/h1-4H |
| InChIKey | VSKSBSORLCDRHS-UHFFFAOYSA-N |
| SMILES | Fc1cccc(I)c1 |
| CAS DataBase Reference | 1121-86-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-fluoro-3-iodo-(1121-86-4) |
| EPA Substance Registry System | m-Fluoroiodobenzene (1121-86-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29039990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-Fluoro-3-iodobenzene price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 219398 | 3-Fluoroiodobenzene 99% | 1121-86-4 | 25g | $84 | 2026-04-30 | Buy |
| TCI Chemical | F0260 | 1-Fluoro-3-iodobenzene (stabilized with Copper chip) >99.0%(GC) | 1121-86-4 | 25g | $150 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0038 | 1-Fluoro-3-iodobenzene , stabilised with Copper, min. 99% min.99% | 1121-86-4 | 25g | $52 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0038 | 1-Fluoro-3-iodobenzene , stabilised with Copper, min. 99% min.99% | 1121-86-4 | 100g | $156 | 2026-04-30 | Buy |
| Usbiological | 278213 | 1-Fluoro-3-iodobenzene (stabilized with Copper chip) Asreported | 1121-86-4 | 25g | $350 | 2026-06-03 | Buy |
1-Fluoro-3-iodobenzene Chemical Properties, Uses, Production
Chemical Properties
clear yellow or pink liquid
Uses
3-Fluoroiodobenzene was used to prepare methyl 4-iodobenzo[b]thiophene-2-carboxylate, key intermediate for the synthesis of 4-substituted benzo[b]thiophene-2-carboxamidines.
General Description
3-Fluoroiodobenzene participates in palladium-catalyzed hydroarylation of arylpropiolamides.
Synthesis
372-19-0
1121-86-4
The general procedure for the synthesis of m-fluoroiodobenzene from 3-fluoroaniline was as follows: an aqueous solution (20 mL) of NaNO2 (6.4 g, 92.75 mmol) was slowly added dropwise at 0 °C to a solution of 3-fluoroaniline (10 g, 90.09 mmol) dissolved in 32% H2SO4 (179 g). The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, an aqueous solution (30 mL) of KI (22.4 g, 134.94 mmol) was added while maintaining 0 °C and stirring was continued at 0 °C for 1 hour. After completion of the reaction, the aqueous phase was extracted with EtOAc (2 x 250 mL). The organic phases were combined and washed sequentially with water (5×200mL) and 10% NaHSO3 solution (3×200mL), dried over Na2SO4 and concentrated under reduced pressure to remove the solvent, yielding 17.7 g of 1-fluoro-3-iodobenzene as a yellow solid in 82% yield.
References
[1] Patent: WO2008/103615, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of the American Chemical Society, 1963, vol. 85, p. 709 - 724
1-Fluoro-3-iodobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jintan Winbond Chemical Co., Ltd. | 0519-82610098 18605286750 | sales@huabangchemical.com | China | 153 | 58 |
| Huai'an Chenhui Technology Co., Ltd. | 13056011912 | jianshen1977@126.com | China | 26 | 58 |
| Fuxin Simai Chemical Technology Co., Ltd. | 13841818553 | 929964679@qq.com | China | 446 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 1-Fluoro-3-iodobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | 3-iodofluorobenzene
1121-86-4
|
$250.00 | 1KG | 98% | 20 tons | Speranza Chemical Co., Ltd. | |
 |
2026-09-02 | 1-Fluoro-3-iodobenzene
1121-86-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-04-21 | Benzene, 1-fluoro-3-iodo-
1121-86-4
|
$37.00 | 10g | TargetMol Chemicals Inc. |
-
- 3-iodofluorobenzene
1121-86-4
- $250.00
- 98%
- Speranza Chemical Co., Ltd.
-
- 1-Fluoro-3-iodobenzene
1121-86-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Benzene, 1-fluoro-3-iodo-
1121-86-4
- $37.00
- TargetMol Chemicals Inc.
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