Tangeretin
- CAS No.
- 481-53-8
- Chemical Name:
- Tangeretin
- Synonyms
- TANGERITIN;NSC 53909;angeretin;NSC 618905;TANGERETIN;ponkanetin;TANGARETIN;Tangeritine;TANGERETIN(P);Tangeretin-RM
- CBNumber:
- CB3409585
- Molecular Formula:
- C20H20O7
- Molecular Weight:
- 372.37
- MDL Number:
- MFCD00017438
- MOL File:
- 481-53-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tangeretin ≥95% (HPLC) | T8951 | 5mg | $249 |
| Tangeretin phyproof? Reference Substance | PHL89803 | 20MG | $444 |
| Tangeretin analytical standard | 91004 | 10mg | $375 |
| Tangeretin >96.0%(HPLC) | T2708 | 10mg | $19 |
| Tangeretin >96.0%(HPLC) | T2708 | 100mg | $108 |
| More product size | |||
| Melting point | 153.0 to 157.0 °C |
|---|---|
| Boiling point | 565.3±50.0 °C(Predicted) |
| Density | 1.244±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : 25 mg/mL (67.14 mM; Need ultrasonic) |
| form | Solid |
| color | White to Almost white |
| BRN | 351695 |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING ANTIOXIDANT |
| InChI | InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3 |
| InChIKey | ULSUXBXHSYSGDT-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(OC)C=C2)OC2=C(OC)C(OC)=C(OC)C(OC)=C2C(=O)C=1 |
| LogP | 1.788 (est) |
| CAS DataBase Reference | 481-53-8(CAS DataBase Reference) |
| FDA UNII | I4TLA1DLX6 |
| NIST Chemistry Reference | Tangeretin(481-53-8) |
| UNSPSC Code | 85151701 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P301+P310 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 45-36-26 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ3102725 | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | rat,LD50,intraperitoneal,> 1gm/kg (1000mg/kg),Advances in Teratology. Vol. 3, Pg. 181, 1968. | |||||||||
| NFPA 704 |
|
Tangeretin price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T8951 | Tangeretin ≥95% (HPLC) | 481-53-8 | 5mg | $249 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL89803 | Tangeretin phyproof? Reference Substance | 481-53-8 | 20MG | $444 | 2026-04-30 | Buy |
| Sigma-Aldrich | 91004 | Tangeretin analytical standard | 481-53-8 | 10mg | $375 | 2022-05-15 | Buy |
| TCI Chemical | T2708 | Tangeretin >96.0%(HPLC) | 481-53-8 | 10mg | $19 | 2026-04-30 | Buy |
| TCI Chemical | T2708 | Tangeretin >96.0%(HPLC) | 481-53-8 | 100mg | $108 | 2026-04-30 | Buy |
Tangeretin Chemical Properties,Uses,Production
Chemical Properties
Tangeretin is a yellow crystal that is volatile, difficult to dissolve in water, and easily soluble in organic solvents such as ethanol and ether. It is the active ingredient in tangerine peel. It has a good effect in treating animal mites.
Uses
Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.
Definition
ChEBI: Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite.
General Description
Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.
Biological Activity
Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.
in vivo
In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice[2].
References
[1] K. AGRAWAL Y. M. Tangeretin: A Biologically Potential Citrus Flavone[J]. Current Traditional Medicine, 2022. DOI:10.2174/2215083808666220304100702.
[2] JUHEE SEO . Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation[J]. European journal of pharmacology, 2011, 673 1: Pages 56-64. DOI:10.1016/j.ejphar.2011.10.011.
[3] Z CHENG. Tangeretin and its metabolite 4′-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K[J]. British Journal of Pharmacology, 2010, 162 8: 1781-1791. DOI:10.1111/j.1476-5381.2010.01185.x.
[4] GUY LEWIN*. Semisynthesis of Natural Flavones Inhibiting Tubulin Polymerization, from Hesperidin[J]. Journal of Natural Products , 2010, 73 4: 702-706. DOI:10.1021/np100065v.
[5] WASEEM RAZA Abha M Suaib Luqman. Prospects of tangeretin as a modulator of cancer targets/pathways[J]. Pharmacological research, 2020, 161: Article 105202. DOI:10.1016/j.phrs.2020.105202.
Tangeretin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 477 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
View Lastest Price from Tangeretin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Tangeretin
481-53-8
|
US $38.00-156.00 / mg | 99.47% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-01 | Tangeretin
481-53-8
|
US $0.00-0.00 / KG | 1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-13 | Tangeretin
481-53-8
|
US $0.00 / kg | 1kg | 40%-98%； | 1000 kg | BINBO BIOLOGICAL CO.,LTD |
-
- Tangeretin
481-53-8
- US $38.00-156.00 / mg
- 99.47%
- TargetMol Chemicals Inc.
-
- Tangeretin
481-53-8
- US $0.00-0.00 / KG
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- Tangeretin
481-53-8
- US $0.00 / kg
- 40%-98%；
- BINBO BIOLOGICAL CO.,LTD
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