6-(Trifluoromethyl)nicotinic acid
- CAS No.
- 231291-22-8
- Chemical Name:
- 6-(Trifluoromethyl)nicotinic acid
- Synonyms
- 3,5-Dichloropyrazine-2-carboxylic acid;6-(Trifluoromethyl)-3-pyridinecarboxylic acid;6-(TrifL;6-Trifluoromethyl;RARECHEM AL BO 1001;6-(TRIFLUOROMETHYL)PYRIDI;6-Trifluoromethylnicotic acid;TRIFLUOROMETHYL NICOTINIC ACID;6-(TRIFLUROMETHYL)NICOTINICACID;6- threefluorine Methylnicotinate
- CBNumber:
- CB3440751
- Molecular Formula:
- C7H4F3NO2
- Molecular Weight:
- 191.11
- MDL Number:
- MFCD00792430
- MOL File:
- 231291-22-8.mol
- MSDS File:
- SDS
| Melting point | 193-197 °C(lit.) |
|---|---|
| Boiling point | 259.3±40.0 °C(Predicted) |
| Density | 1.484±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Acetonitrile (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 2.96±0.10(Predicted) |
| color | Pale Beige to Light Brown |
| InChI | InChI=1S/C7H4F3NO2/c8-7(9,10)5-2-1-4(3-11-5)6(12)13/h1-3H,(H,12,13) |
| InChIKey | JNYLMODTPLSLIF-UHFFFAOYSA-N |
| SMILES | C1=NC(C(F)(F)F)=CC=C1C(O)=O |
| CAS DataBase Reference | 231291-22-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
6-(Trifluoromethyl)nicotinic acid price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T2203 | 6-(Trifluoromethyl)nicotinic Acid >98.0%(GC) | 231291-22-8 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | T2203 | 6-(Trifluoromethyl)nicotinic Acid >98.0%(GC) | 231291-22-8 | 5g | $135 | 2026-04-30 | Buy |
| TRC | TRC-T790650-5G | 6-Trifluoromethyl Nicotinic Acid | 5g | $701 | 2026-06-03 | Buy | |
| TRC | TRC-T790650-2.5G | 6-Trifluoromethyl Nicotinic Acid | 2.5g | $415 | 2026-06-03 | Buy | |
| TRC | TRC-T790650-1G | 6-Trifluoromethyl Nicotinic Acid | 1g | $205 | 2026-06-03 | Buy |
6-(Trifluoromethyl)nicotinic acid Chemical Properties,Uses,Production
Physical properties
6-Trifluoromethylnicotinic acid is a white powder with a melting point of 193-197 °C. It has a boiling point of 259.3℃ at 760 mmHg. Its density is 1.484 g/cm3. Its flash point, refractive index and vapor pressure are 110.6℃, 1.475 and 0.007mmHg at 25°C, respectively.
Uses
6-(Trifluoromethyl)nicotinic acid can be used to prepare Raf inhibitors to treat cancer.
Application
6-(Trifluoromethyl)nicotinic acid is a key intermediate of many fluorine-containing drugs.
Hazard
6-(Trifluoromethyl)nicotinic acid causes skin irritation and serious eye irritation.
Synthesis
216431-85-5
231291-22-8
To a 10L three-necked flask were added 1420 g of water, 2440 g of sulfuric acid, and 150 mL of glacial acetic acid, and 870 g (5 mol) of 6-(trifluoromethyl)nicotinonitrile was added slowly. The mixture was heated to reflux and kept overnight. Upon completion of the reaction, the reaction mixture was cooled, ice was added and the mixture was cooled using ice brine to precipitate a white solid. After filtration, the filtrate was extracted with ethyl acetate. The organic phases were combined and washed twice with water, followed by drying the organic phase to acidity. After washing, 930 g of 6-(trifluoromethyl)-3-pyridinecarboxylic acid was obtained as a beige solid in 97.3% yield.
References
[1] Patent: CN107298677, 2017, A. Location in patent: Paragraph 0036-0038
[2] Patent: CN107337638, 2017, A. Location in patent: Paragraph 0031; 0032; 0033
[3] Patent: EP1122242, 2001, A1
[4] Patent: US6673799, 2004, B1. Location in patent: Page column 16
6-(Trifluoromethyl)nicotinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Weiyuan Technology Co., Ltd. | 13024122785 17356341931 | sales@shweiyuan.cn | China | 283 | 58 |
| Nanjing YiFan Biological Technology Co., Ltd. | 025-025-52700520 18914499889 | sales@yfbiotech.com | China | 494 | 58 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Shanghai Fei Yan Chemical Technology Co., Ltd. | 021-34663897 13816465839 | 1141976404@qq.com | China | 41 | 57 |
| Beijing Sintong Pharma Technology Co., Ltd. | 13466647005 | 47652055@qq.com | China | 393 | 58 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 289 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
Related articles
- Synthesis of 6-(Trifluoromethyl)nicotinic acid
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- Aug 23,2022
View Lastest Price from 6-(Trifluoromethyl)nicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-(Trifluoromethyl)nicotinic acid
231291-22-8
|
$1.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 6-(Trifluoromethyl)nicotinic acid
231291-22-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-03-20 | 6-(Trifluoromethyl)nicotinic acid
231291-22-8
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 6-(Trifluoromethyl)nicotinic acid
231291-22-8
- $1.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 6-(Trifluoromethyl)nicotinic acid
231291-22-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-(Trifluoromethyl)nicotinic acid
231291-22-8
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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