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2-Bromo-5-fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Structure
2-Bromo-5-fluorobenzotrifluoride structure
CAS No.
40161-55-5
Chemical Name:
2-Bromo-5-fluorobenzotrifluoride
Synonyms
1-BROMO-4-FLUORO-2-(TRIFLUOROMETHYL)BENZENE;5-(N-hydroxyethy0)-amino;2-BROMO-5-FLUOROBENZOTRIFLUORIDE;5-fluoro-2-bromobenzoTrifluoride;2-bromo-5-fluorotrifluorotoluene;2-Bromo-Α,Α,Α,5-Tetrafluorotoluene;2-Bromo-5-fluorobenzotrifluoride 97%;2-Bromo-5-fluorobenzotrifluoride >2-Bromo-5-fluorobenzotrifluoride, 97+%;2-Bromo-5-fluoro-α,α,α-trifluorotoluene
CBNumber:
CB3427370
Molecular Formula:
C7H3BrF4
Molecular Weight:
243
MDL Number:
MFCD00040937
MOL File:
40161-55-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:31:42
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2-Bromo-5-fluorobenzotrifluoride Properties

Boiling point 136-143 °C(lit.)
Density 1.695 g/mL at 25 °C(lit.)
refractive index n20/D 1.465(lit.)
Flash point 147 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light orange to Yellow
BRN 2643544
InChI InChI=1S/C7H3BrF4/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H
InChIKey AIDVAZGOACECLJ-UHFFFAOYSA-N
SMILES C1(Br)=CC=C(F)C=C1C(F)(F)F
CAS DataBase Reference 40161-55-5(CAS DataBase Reference)
NIST Chemistry Reference 2-Bromo-5-fluorobenzotrifluoride(40161-55-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H227-H315-H319
Precautionary statements  P210e-P261-P280a-P305+P351+P338-P405-P501a-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36/37/39-37-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29039990
NFPA 704
2
2 0

2-Bromo-5-fluorobenzotrifluoride price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 546909 2-Bromo-5-fluorobenzotrifluoride 97% 40161-55-5 1g $33.6 2023-06-20 Buy
Sigma-Aldrich 546909 2-Bromo-5-fluorobenzotrifluoride 97% 40161-55-5 5g $90 2023-06-20 Buy
TCI Chemical B2800 2-Bromo-5-fluorobenzotrifluoride >97.0%(GC) 40161-55-5 5g $27 2026-04-30 Buy
TCI Chemical B2800 2-Bromo-5-fluorobenzotrifluoride >97.0%(GC) 40161-55-5 25g $78 2026-04-30 Buy
AK Scientific J98263 2-Bromo-5-fluorobenzotrifluoride 95% 40161-55-5 5g $12 2026-06-04 Buy
Product number Packaging Price Buy
546909 1g $33.6 Buy
546909 5g $90 Buy
B2800 5g $27 Buy
B2800 25g $78 Buy
J98263 5g $12 Buy

2-Bromo-5-fluorobenzotrifluoride Chemical Properties, Uses, Production

Chemical Properties

Colorless liquid

Uses

2-Bromo-5-fluorobenzotrifluoride is an organofluorobenzene compound mainly used as an organic reagent and pharmaceutical intermediate, and can be used as a starting material for the preparation of HSD-016.  HSD-016 inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD1) to convert cortisone into cortisol for the development of drugs for the treatment of type 2 diabetes.

Synthesis

4-Bromo-3-(trifluoromethyl)aniline

393-36-2

2-Bromo-5-fluorobenzotrifluoride

40161-55-5

The 1L stainless steel reactor was cooled to -10 °C and then 450 g of anhydrous hydrofluoric acid and 6.0 g of anhydrous potassium fluoride were added to the reactor. Subsequently, 248 g of 5-amino-2-bromobenzotrifluoride was added and 75.5 g of sodium nitrite was added slowly, ensuring that the temperature of the reaction system did not exceed 5 °C. Stirring was done for 30 minutes to complete the diazotization reaction. The temperature of the reaction system was raised to 60°C and maintained, at which time the fluorinated diazonium salt began to decompose slowly and release gases, which were absorbed by the base after passing through the cooling buffer. After the reaction is complete and no more gas is released, the excess hydrofluoric acid in the reactor is recovered and the mixture is cooled to 0°C. A 10% KOH solution was added to the reactor to neutral and steam distillation was carried out to obtain 233 g of crude 2-bromo-5-fluorobenzotrifluoride. The distillation was carried out by filling a distillation column and the 110°C-120°C fractions were collected at a pressure of 40 mmHg to obtain 209 g of a colorless transparent liquid, 2-bromo-5-fluorobenzotrifluoride, with a GC purity of 99% and a yield of 86.8%.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0023
[2] Patent: CN104447183, 2016, B. Location in patent: Paragraph 0112-0134
[3] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 9

2-Bromo-5-fluorobenzotrifluoride synthesis

392-83-6
5942-30-3
Synthesis of 2-Bromo-5-fluorobenzotrifluoride from 2-Bromobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Preparation Products And Raw materials

Raw materials

3-Fluorobenzotrifluoride 4-Bromo-3-(trifluoromethyl)aniline

Preparation Products

Mefentrifluconazole 2-Fluoro-4-trifluoromethylphenylboronic acid, pinacol ester 4-Fluoro-2-(trifluoromethyl)benzaldehyde 3-Fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Suppliers

Global Suppliers ( 402)
Supplier Tel Email Country ProdList Advantage
Weifang QianJin Fine Chemical Co., Ltd. 18753684562 1577399715@qq.COM China 1772 55
JIANGYIN RUISHIPHARM CO.,LIMITED 0510-0510-66227179 18921203887 sales@ruishipharm.com China 747 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
HUBEI ZHENBO CHEM CO,LTD 18040568358 18086513998 1517727943@qq.com China 298 58
Beijing Jinrui Meixiang Technology Co., Ltd 13691579162 480326527@qq.com China 498 58
Anhui Weihe Chemical Technology Co., Ltd. 13505592528 13505592528 49141484@qq.com China 2671 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Weifang QianJin Fine Chemical Co., Ltd. 55
JIANGYIN RUISHIPHARM CO.,LIMITED 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
HUBEI ZHENBO CHEM CO,LTD 58
Beijing Jinrui Meixiang Technology Co., Ltd 58
Anhui Weihe Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Alfa Aesar 84

View Latest Price from 2-Bromo-5-fluorobenzotrifluoride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-fluorobenzotrifluoride pictures 2026-06-30 2-Bromo-5-fluorobenzotrifluoride
40161-55-5
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Bromo-5-fluorobenzotrifluoride pictures 2026-05-28 2-Bromo-5-fluorobenzotrifluoride
40161-55-5
 $10.00 1KG 99.% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
2-Bromo-5-fluorobenzotrifluoride pictures 2026-03-20 2-Bromo-5-fluorobenzotrifluoride
40161-55-5
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd

2-Bromo-5-fluorobenzotrifluoride Spectrum

2-Bromo-5-fluorobenzotrifluoride(40161-55-5)1HNMR2-Bromo-5-fluorobenzotrifluoride(40161-55-5)IR

40161-55-5 (2-Bromo-5-fluorobenzotrifluoride) Related Search:

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4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE 2-Bromo-5-fluorobenzotrifluoride, 97+% 2-BROMO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-BROMO-5-FLUOROBENZOTRIFLUORIDE 1-BROMO-2-(TRIFLUOROMETHYL)-4-FLUOROBENZENE 4-Fluoro-2-trifluoromethyl-phenylboronic acid 5-fluoro-2-bromobenzoTrifluoride 2-Bromo-5-fluorobenzotrifluoride 97% 2-Bromo-alpha,alpha,alpha,5-tetrafluorotoluene 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene, 2-Bromo-alpha,alpha,alpha,5-tetrafluorotoluene Benzene, 1-bromo-4-fluoro-2-(trifluoromethyl)- 2-bromo-5-fluorotrifluorotoluene 2-Bromo-Α,Α,Α,5-Tetrafluorotoluene 1-Bromo-4-Fluor-2-(Trifluoromethyl)Benzene 2-Bromo-5-fluorobenzotrifluoride > 2-Bromo-5-fluoro-α,α,α-trifluorotoluene 1-BROMO-4-FLUORO-2-(TRIFLUOROMETHYL)BENZENE 5-(N-hydroxyethy0)-amino 40161-55-5 41061-55-5 844868-03-9 C7H3BrF4 C7 Aryl Building Blocks Halogenated Hydrocarbons Organic Building Blocks Fluorine series Chemical Synthesis Fluorinated Building Blocks Halogenated Hydrocarbons Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Fluorobenzene Miscellaneous Bromine Compounds Fluorine Compounds Benzotrifluoride Series Trifluoromethylbenzene serise Aryl C7 Halogenated Hydrocarbons Aryl Fluorinated Building Blocks Building Blocks