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2-Bromo-5-fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Structure
2-Bromo-5-fluorobenzotrifluoride structure
CAS No.
40161-55-5
Chemical Name:
2-Bromo-5-fluorobenzotrifluoride
Synonyms
5-fluoro-2-bromobenzoTrifluoride;2-BROMO-5-FLUOROBENZOTRIFLUORIDE;2-bromo-5-fluorotrifluorotoluene;2-Bromo-Α,Α,Α,5-Tetrafluorotoluene;2-Bromo-5-fluorobenzotrifluoride 97%;2-Bromo-5-fluorobenzotrifluoride >2-Bromo-5-fluorobenzotrifluoride, 97+%;2-Bromo-5-fluoro-α,α,α-trifluorotoluene;4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE;1-Bromo-4-Fluor-2-(Trifluoromethyl)Benzene
CBNumber:
CB3427370
Molecular Formula:
C7H3BrF4
Molecular Weight:
243
MDL Number:
MFCD00040937
MOL File:
40161-55-5.mol
Last updated:2025-07-24 18:13:47
Product description Number Pack Size Price
2-Bromo-5-fluorobenzotrifluoride 97% 546909 1g $33.6
2-Bromo-5-fluorobenzotrifluoride 97% 546909 5g $90
2-Bromo-5-fluorobenzotrifluoride >97.0%(GC) B2800 5g $33
2-Bromo-5-fluorobenzotrifluoride >97.0%(GC) B2800 25g $97
1-Bromo-4-fluoro-2-(trifluoromethyl)benzene B685778 2.5g $65
More product size
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2-Bromo-5-fluorobenzotrifluoride Properties

Boiling point 136-143 °C(lit.)
Density 1.695 g/mL at 25 °C(lit.)
refractive index n20/D 1.465(lit.)
Flash point 147 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light orange to Yellow
BRN 2643544
InChI InChI=1S/C7H3BrF4/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H
InChIKey AIDVAZGOACECLJ-UHFFFAOYSA-N
SMILES C1(Br)=CC=C(F)C=C1C(F)(F)F
CAS DataBase Reference 40161-55-5(CAS DataBase Reference)
NIST Chemistry Reference 2-Bromo-5-fluorobenzotrifluoride(40161-55-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H227-H315-H319
Precautionary statements  P210e-P261-P280a-P305+P351+P338-P405-P501a-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36/37/39-37-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29039990
NFPA 704
2
2 0

2-Bromo-5-fluorobenzotrifluoride price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 546909 2-Bromo-5-fluorobenzotrifluoride 97% 40161-55-5 1g $33.6 2023-06-20 Buy
Sigma-Aldrich 546909 2-Bromo-5-fluorobenzotrifluoride 97% 40161-55-5 5g $90 2023-06-20 Buy
TCI Chemical B2800 2-Bromo-5-fluorobenzotrifluoride >97.0%(GC) 40161-55-5 5g $33 2025-07-31 Buy
TCI Chemical B2800 2-Bromo-5-fluorobenzotrifluoride >97.0%(GC) 40161-55-5 25g $97 2025-07-31 Buy
TRC B685778 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene 40161-55-5 2.5g $65 2021-12-16 Buy
Product number Packaging Price Buy
546909 1g $33.6 Buy
546909 5g $90 Buy
B2800 5g $33 Buy
B2800 25g $97 Buy
B685778 2.5g $65 Buy

2-Bromo-5-fluorobenzotrifluoride Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Uses

2-Bromo-5-fluorobenzotrifluoride is an organofluorobenzene compound mainly used as an organic reagent and pharmaceutical intermediate, and can be used as a starting material for the preparation of HSD-016.  HSD-016 inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD1) to convert cortisone into cortisol for the development of drugs for the treatment of type 2 diabetes.

Synthesis

4-Bromo-3-(trifluoromethyl)aniline

393-36-2

2-Bromo-5-fluorobenzotrifluoride

40161-55-5

The 1L stainless steel reactor was cooled to -10 °C and then 450 g of anhydrous hydrofluoric acid and 6.0 g of anhydrous potassium fluoride were added to the reactor. Subsequently, 248 g of 5-amino-2-bromobenzotrifluoride was added and 75.5 g of sodium nitrite was added slowly, ensuring that the temperature of the reaction system did not exceed 5 °C. Stirring was done for 30 minutes to complete the diazotization reaction. The temperature of the reaction system was raised to 60°C and maintained, at which time the fluorinated diazonium salt began to decompose slowly and release gases, which were absorbed by the base after passing through the cooling buffer. After the reaction is complete and no more gas is released, the excess hydrofluoric acid in the reactor is recovered and the mixture is cooled to 0°C. A 10% KOH solution was added to the reactor to neutral and steam distillation was carried out to obtain 233 g of crude 2-bromo-5-fluorobenzotrifluoride. The distillation was carried out by filling a distillation column and the 110°C-120°C fractions were collected at a pressure of 40 mmHg to obtain 209 g of a colorless transparent liquid, 2-bromo-5-fluorobenzotrifluoride, with a GC purity of 99% and a yield of 86.8%.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0023
[2] Patent: CN104447183, 2016, B. Location in patent: Paragraph 0112-0134
[3] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 9

2-Bromo-5-fluorobenzotrifluoride synthesis

392-83-6
5942-30-3
Synthesis of 2-Bromo-5-fluorobenzotrifluoride from 2-Bromobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Preparation Products And Raw materials

Raw materials

3-Fluorobenzotrifluoride 4-Bromo-3-(trifluoromethyl)aniline

Preparation Products

Mefentrifluconazole 2-FLUORO-4-TRIFLUOROMETHYLPHENYLBORONIC ACID, PINACOL ESTER 4-Fluoro-2-(trifluoromethyl)benzaldehyde 3-Fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Suppliers

Global( 384)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangxi Huihe Chemical Co., Ltd.
+86-19189228086 +8618858568638 wuzhouding@huihecrop.com China 886 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8772 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12247 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5251 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13456 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21620 55
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Supplier Advantage
Jiangxi Huihe Chemical Co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Fluoropharm Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60

View Lastest Price from 2-Bromo-5-fluorobenzotrifluoride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-fluorobenzotrifluoride pictures 2025-10-11 2-Bromo-5-fluorobenzotrifluoride
40161-55-5
 US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Bromo-5-fluorobenzotrifluoride pictures 2025-08-08 2-Bromo-5-fluorobenzotrifluoride
40161-55-5
 US $0.00 / KG 1KG 99% 50000KG/month Sichuan Zhuoyu Yantang Technology Co., Ltd.
2-Bromo-5-fluorobenzotrifluoride pictures 2025-07-25 2-Bromo-5-fluorobenzotrifluoride
40161-55-5
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-Bromo-5-fluorobenzotrifluoride Spectrum

2-Bromo-5-fluorobenzotrifluoride(40161-55-5)1HNMR2-Bromo-5-fluorobenzotrifluoride(40161-55-5)IR

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4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE 2-Bromo-5-fluorobenzotrifluoride, 97+% 2-BROMO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-BROMO-5-FLUOROBENZOTRIFLUORIDE 1-BROMO-4-FLUORO-2-(TRIFLUOROMETHYL)BENZENE 1-BROMO-2-(TRIFLUOROMETHYL)-4-FLUOROBENZENE 4-Fluoro-2-trifluoromethyl-phenylboronic acid 5-fluoro-2-bromobenzoTrifluoride 2-Bromo-5-fluorobenzotrifluoride 97% 2-Bromo-alpha,alpha,alpha,5-tetrafluorotoluene 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene, 2-Bromo-alpha,alpha,alpha,5-tetrafluorotoluene Benzene, 1-bromo-4-fluoro-2-(trifluoromethyl)- 2-bromo-5-fluorotrifluorotoluene 2-Bromo-Α,Α,Α,5-Tetrafluorotoluene 1-Bromo-4-Fluor-2-(Trifluoromethyl)Benzene 2-Bromo-5-fluorobenzotrifluoride > 2-Bromo-5-fluoro-α,α,α-trifluorotoluene 40161-55-5 41061-55-5 C7H3BrF4 C7 Aryl Building Blocks Halogenated Hydrocarbons Organic Building Blocks Fluorine series Chemical Synthesis Fluorinated Building Blocks Halogenated Hydrocarbons Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Fluorobenzene Miscellaneous Bromine Compounds Fluorine Compounds Benzotrifluoride Series Trifluoromethylbenzene serise Aryl C7 Halogenated Hydrocarbons Aryl Fluorinated Building Blocks Building Blocks