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2-Bromo-5-fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride Suppliers list
Company Name: Weifang QianJin Fine Chemical Co., Ltd.  Gold
Tel: 18753684562
Email: 1577399715@qq.COM
Company Name: JIANGYIN RUISHIPHARM CO.,LIMITED  Gold
Tel: 0510-0510-66227179 18921203887
Email: sales@ruishipharm.com
Company Name: Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.  Gold
Tel: 13396369453 18678026865
Email: sdfantai@163.com
Company Name: HUBEI ZHENBO CHEM CO,LTD  Gold
Tel: 18040568358 18086513998
Email: 1517727943@qq.com
Company Name: Beijing Jinrui Meixiang Technology Co., Ltd  Gold
Tel: 13691579162
Email: 480326527@qq.com

2-Bromo-5-fluorobenzotrifluoride manufacturers

2-Bromo-5-fluorobenzotrifluoride Basic information
Product Name:2-Bromo-5-fluorobenzotrifluoride
Synonyms:4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE;2-Bromo-5-fluorobenzotrifluoride, 97+%;2-BROMO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE;2-BROMO-5-FLUOROBENZOTRIFLUORIDE;1-BROMO-2-(TRIFLUOROMETHYL)-4-FLUOROBENZENE;4-Fluoro-2-trifluoromethyl-phenylboronic acid;5-fluoro-2-bromobenzoTrifluoride;2-Bromo-5-fluorobenzotrifluoride 97%
CAS:40161-55-5
MF:C7H3BrF4
MW:243
EINECS:210-702-0
Product Categories:Fluorine series;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorobenzene;Miscellaneous;Bromine Compounds;Fluorine Compounds;Benzotrifluoride Series;Trifluoromethylbenzene serise;Aryl;C7;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks
Mol File:40161-55-5.mol
2-Bromo-5-fluorobenzotrifluoride Structure
2-Bromo-5-fluorobenzotrifluoride Chemical Properties
Boiling point 136-143 °C(lit.)
density 1.695 g/mL at 25 °C(lit.)
refractive index n20/D 1.465(lit.)
Fp 147 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light orange to Yellow
BRN 2643544
InChIInChI=1S/C7H3BrF4/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H
InChIKeyAIDVAZGOACECLJ-UHFFFAOYSA-N
SMILESC1(Br)=CC=C(F)C=C1C(F)(F)F
CAS DataBase Reference40161-55-5(CAS DataBase Reference)
NIST Chemistry Reference2-Bromo-5-fluorobenzotrifluoride(40161-55-5)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36/37/39-37-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29039990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
2-Bromo-5-fluorobenzotrifluoride Usage And Synthesis
Chemical PropertiesColorless liquid
Uses2-Bromo-5-fluorobenzotrifluoride is an organofluorobenzene compound mainly used as an organic reagent and pharmaceutical intermediate, and can be used as a starting material for the preparation of HSD-016.  HSD-016 inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD1) to convert cortisone into cortisol for the development of drugs for the treatment of type 2 diabetes.
Synthesis
4-Bromo-3-(trifluoromethyl)aniline

393-36-2

2-Bromo-5-fluorobenzotrifluoride

40161-55-5

The 1L stainless steel reactor was cooled to -10 °C and then 450 g of anhydrous hydrofluoric acid and 6.0 g of anhydrous potassium fluoride were added to the reactor. Subsequently, 248 g of 5-amino-2-bromobenzotrifluoride was added and 75.5 g of sodium nitrite was added slowly, ensuring that the temperature of the reaction system did not exceed 5 °C. Stirring was done for 30 minutes to complete the diazotization reaction. The temperature of the reaction system was raised to 60°C and maintained, at which time the fluorinated diazonium salt began to decompose slowly and release gases, which were absorbed by the base after passing through the cooling buffer. After the reaction is complete and no more gas is released, the excess hydrofluoric acid in the reactor is recovered and the mixture is cooled to 0°C. A 10% KOH solution was added to the reactor to neutral and steam distillation was carried out to obtain 233 g of crude 2-bromo-5-fluorobenzotrifluoride. The distillation was carried out by filling a distillation column and the 110°C-120°C fractions were collected at a pressure of 40 mmHg to obtain 209 g of a colorless transparent liquid, 2-bromo-5-fluorobenzotrifluoride, with a GC purity of 99% and a yield of 86.8%.

References[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0023
[2] Patent: CN104447183, 2016, B. Location in patent: Paragraph 0112-0134
[3] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 9
Tag:2-Bromo-5-fluorobenzotrifluoride(40161-55-5) Related Product Information
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