Oxythiamine chloride hydrochloride
- CAS No.
- 614-05-1
- Chemical Name:
- Oxythiamine chloride hydrochloride
- Synonyms
- OXYTHIAMINE HYDROCHLORIDE;OXYTHIAMINE HCL;Oxythiamine Chloride HCl;Oxametholone Hydrochloride;OXYTHIAMINE CHLORIDE HYDROCHLORIDE;OXYTHIAMINE CHLORIDE HYDROCHLORIDE;OXYTHIAMINE CHLORIDE HCL CRYSTALLINE;hydroxythiaminechloridehydrochloride;hyl)-4-methyl-,chloride,monohydrochloride;Thiamine Impurity 19（Oxythiamine Chloride HCl）
- CBNumber:
- CB3428625
- Molecular Formula:
- C12H17Cl2N3O2S
- Molecular Weight:
- 338.25
- MDL Number:
- MFCD00050656
- MOL File:
- 614-05-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >190°C (subl.) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChI | 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H |
| InChIKey | QHUYPZVMEJLSEB-UHFFFAOYSA-N |
| SMILES | CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-] |
| FDA UNII | HM0RL1Q94J |
| UNSPSC Code | 12352116 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| RTECS | XJ7034100 |
| Storage Class | 11 - Combustible Solids |
Oxythiamine chloride hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O4000 | Oxythiamine chloride hydrochloride ≥95% (HPLC) | 614-05-1 | 1g | $57.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | O4000 | Oxythiamine chloride hydrochloride ≥95% (HPLC) | 614-05-1 | 5g | $177 | 2026-04-30 | Buy |
| Cayman Chemical | 29953 | Oxythiamine (chloride hydrochloride) ≥95% | 614-05-1 | 1g | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 29953 | Oxythiamine (chloride hydrochloride) ≥95% | 614-05-1 | 5g | $154 | 2026-04-30 | Buy |
| Cayman Chemical | 29953 | Oxythiamine (chloride hydrochloride) ≥95% | 614-05-1 | 10g | $283 | 2026-04-30 | Buy |
Oxythiamine chloride hydrochloride Chemical Properties, Uses, Production
Uses
thiamine antagonist
Uses
Oxythiamine chloride hydrochloride is suitable for use:
- as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
- as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
- in the synthesis of oxythiamineH picrolonate salt
Definition
ChEBI: A hydrochloride obtained by combining oxythiamine chloride with one molar equivalent of hydrochloric acid.
General Description
Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.
Biochem/physiol Actions
Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.
in vivo
Oxythiamine chloride hydrochloride (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice[2].
Oxythiamine chloride hydrochloride (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells[4].
| Animal Model: | Ehrlich's ascites tumor hosting mice[2] |
| Dosage: | 100-500 mg/kg |
| Administration: | i.p., 4 days |
| Result: | Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg. |
Oxythiamine chloride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Oxythiamine chloride hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
