Oxythiamine
- CAS No.
- 136-16-3
- Chemical Name:
- Oxythiamine
- Synonyms
- azolium;oxythiamin;oxythiamine;Hydroxythiamin;oxythiamine(1+);OXYTHIAMINE HCL;Thiamine Impurity 19;OXYTHIAMINE HYDROCHLORIDE;Oxythiamine·HCl≥ 99% (assay);Oxythiamine (Hydroxythiamin)
- CBNumber:
- CB6428626
- Molecular Formula:
- C12H17Cl2N3O2S
- Molecular Weight:
- 338.25
- MDL Number:
- MFCD00050656
- MOL File:
- 136-16-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.2416 (rough estimate) |
|---|---|
| refractive index | 1.6740 (estimate) |
| storage temp. | −20°C |
| solubility | DMSO : 51.67 mg/mL (194.00 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 1MF36SYZ22 |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| RTECS | XJ7034100 |
| Toxicity | LD50 scu-mus: 1430 mg/kg PCJOAU16,848,82 |
Oxythiamine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0028461 | Oxythiamine 96.28% | 136-16-3 | 5mg | $27 | 2026-06-04 | Buy |
| ChemScene | CS-0028461 | Oxythiamine 96.28% | 136-16-3 | 10mg | $38 | 2026-06-04 | Buy |
| ChemScene | CS-0028461 | Oxythiamine 96.28% | 136-16-3 | 25mg | $70 | 2026-06-04 | Buy |
| ChemScene | CS-0028461 | Oxythiamine 96.28% | 136-16-3 | 50mg | $114 | 2026-06-04 | Buy |
| ChemScene | CS-0028461 | Oxythiamine 96.28% | 136-16-3 | 100mg | $173 | 2026-06-04 | Buy |
Oxythiamine Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].
Definition
ChEBI: A 1,3-thiazolium cation that is 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole alkylated at the N3 position by a (2-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)methyl group.
Safety Profile
Moderately toxic by subcutaneous route. Experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx and SOx.
in vivo
Oxythiamine (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice[2].
Oxythiamine (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells[4].
| Animal Model: | Ehrlich's ascites tumor hosting mice[2] |
| Dosage: | 100-500 mg/kg |
| Administration: | i.p., 4 days |
| Result: | Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg. |
References
[1] Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. DOI:10.1186/2162-3619-2-18
[2] Ras B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. DOI:10.1016/s0014-5793(99)00924-2
[3] Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. DOI:10.1007/s11571-021-09725-7
[4] Yang CM, et al. The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis. 2010 May;27(5):341-9. DOI:10.1007/s10585-010-9331-2
Oxythiamine Preparation Products And Raw materials
Raw materials
Preparation Products
Oxythiamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@yongstandards.com | China | 9995 | 55 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2377 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
