1,4-Diaminobutane dihydrochloride
- CAS No.
- 333-93-7
- Chemical Name:
- 1,4-Diaminobutane dihydrochloride
- Synonyms
- PUTRESCINE DIHYDROCHLORIDE;Putrescine 2HCl;BDADCl;Putrescin dihydrochloride;DIAMINOBUTANE DIHYDROCHLORIDE;Putrescine dih;Putrescine dihydrochL;1,4-DIAMINOBUTANE 2HCL;4-Diaminobutane ? 2HCl;1,4-Diaminobutane DiHCl
- CBNumber:
- CB3454202
- Molecular Formula:
- C4H14Cl2N2
- Molecular Weight:
- 161.07
- MDL Number:
- MFCD00012526
- MOL File:
- 333-93-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 280 °C (dec.)(lit.) |
|---|---|
| Boiling point | 265.47°C (rough estimate) |
| Density | 1.2524 (rough estimate) |
| vapor pressure | 436 Pa ( 25 °C) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | H2O: 100 mg/mL |
| form | powder |
| color | White |
| explosive limit | 0.7-11.2% (v/v) |
| biological source | synthetic (organic) |
| Water Solubility | almost transparency |
| Sensitive | Hygroscopic |
| Merck | 14,7947 |
| BRN | 3906680 |
| Stability | Stable, but hygroscopic. Substances to be avoided: strong oxidizing agents. Combustible. |
| InChI | 1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H |
| InChIKey | XXWCODXIQWIHQN-UHFFFAOYSA-N |
| SMILES | Cl[H].Cl[H].NCCCCN |
| CAS DataBase Reference | 333-93-7(CAS DataBase Reference) |
| FDA UNII | X45SUR7RHY |
| EPA Substance Registry System | 1,4-Diaminobutane dihydrochloride (333-93-7) |
| UNSPSC Code | 12352207 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H302-H311-H314-H330 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EJ7280000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29212900 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 3 Dermal Acute Tox. 4 Oral Eye Dam. 1 Skin Corr. 1B |
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| NFPA 704 |
|
1,4-Diaminobutane dihydrochloride price More Price(91)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.21980 | 1,4-Diaminobutane dihydrochloride for synthesis | 333-93-7 | 10 g | $59.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.21980 | 1,4-Diaminobutane dihydrochloride for synthesis | 333-93-7 | 25G | $134 | 2026-04-30 | Buy |
| Sigma-Aldrich | 32810 | 1,4-Diaminobutane dihydrochloride purum, ≥99.0% (AT) | 333-93-7 | 25g | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | 32810 | 1,4-Diaminobutane dihydrochloride purum, ≥99.0% (AT) | 333-93-7 | 100g | $272 | 2026-04-30 | Buy |
| TCI Chemical | P3082 | Putrescine Dihydrochloride [for Protein Research] | 333-93-7 | 5G | $40 | 2026-04-30 | Buy |
1,4-Diaminobutane dihydrochloride Chemical Properties, Uses, Production
Chemical Properties
white powder
Uses
Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.
General Description
Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.
Biochem/physiol Actions
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Synthesis
A mixture of 880 kg of 1,4-butanediamine and 4990 kg of toluene was prepared in the salt-forming reactor and stirred well. Then, the temperature inside the reactor was controlled at 15C and the reaction pressure was 0.12 MPa, and the hydrogen chloride gas was started to be passed into the reactor through the hydrogen chloride gas blow-in tube at a rate of 370 Nm3/h, and the hydrogen chloride passage was stopped after 3 hours, and the diamine dihydrochloride solution was obtained, and the hydrochloride salt obtained was filtered and dried in a triplex machine to obtain the 1,4-butanediamine dihydrochloride solid.
Purification Methods
Crystallise the salt from EtOH/H2O. [Beilstein 4 IV 1284.]
1,4-Diaminobutane dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tangshan Moneide Trading Co., Ltd. | 0315-8309571 15633399667 | sales@moneidechem.com | China | 703 | 57 |
| Shanghai Chiral Chemicals Inc. | 021-37285021 13472570865 | tym7xi@aliyun.com | China | 299 | 64 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
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View Latest Price from 1,4-Diaminobutane dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 1,4-Diaminobutane dihydrochloride
333-93-7
|
1kg | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | 1,4-Diaminobutane dihydrochloride
333-93-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-06-27 | 1,4-Diaminobutane dihydrochloride
333-93-7
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 1,4-Diaminobutane dihydrochloride
333-93-7
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1,4-Diaminobutane dihydrochloride
333-93-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 1,4-Diaminobutane dihydrochloride
333-93-7
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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