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ChemicalBook >> CAS DataBase List >>1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Structure
1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester structure
CAS No.
680596-79-6
Chemical Name:
1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester
Synonyms
4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane;2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,4-Dioxa-Spiro[4,5]Dec-7-En-8-Boronic Acid PinacoL;1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PICOL ESTER;1,4-Dioxaspiro[4.5]-7-decene-8-boronic Acid Pinacol Ester;1,4-Dioxaspiro[4.5]dec-7-ene-8-boronic acid pinacol ester;1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester;(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)BORONIC ACID PINACOL ESTER;1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901;1,4- dioxo spiro [4,5] decan -7- ene -8- borate pinacol ester
CBNumber:
CB3460797
Molecular Formula:
C14H23BO4
Molecular Weight:
266.14
MDL Number:
MFCD04115656
MOL File:
680596-79-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:03
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1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Properties

Melting point 60-62°C
Boiling point 313.9±52.0 °C(Predicted)
Density 1.08±0.1 g/cm3(Predicted)
storage temp. 2-8°C
form powder to crystal
color White to Orange to Green
InChI InChI=1S/C14H23BO4/c1-12(2)13(3,4)19-15(18-12)11-5-7-14(8-6-11)16-9-10-17-14/h5H,6-10H2,1-4H3
InChIKey JCHWHOHZZYWUMP-UHFFFAOYSA-N
SMILES O1C2(CCC(B3OC(C)(C)C(C)(C)O3)=CC2)OCC1
UNSPSC Code 12352103
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  36/37/38-22
Safety Statements  26-36/37/39
WGK Germany  3
HS Code  2932990090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
0
2 0

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 741671 1,4-Dioxaspiro[4.5]dec-7-en-8-boronic acid pinacol ester 97% 680596-79-6 1g $550 2023-06-20 Buy
Sigma-Aldrich 741671 1,4-Dioxaspiro[4.5]dec-7-en-8-boronic acid pinacol ester 97% 680596-79-6 500mg $390 2023-01-07 Buy
TCI Chemical T3566 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene 680596-79-6 250MG $28 2026-04-30 Buy
TCI Chemical T3566 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene 680596-79-6 1G $84 2026-04-30 Buy
Biosynth FT140502 4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 680596-79-6 10g $175.4 2026-06-04 Buy
Product number Packaging Price Buy
741671 1g $550 Buy
741671 500mg $390 Buy
T3566 250MG $28 Buy
T3566 1G $84 Buy
FT140502 10g $175.4 Buy

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Chemical Properties, Uses, Production

Uses

1,4-Dioxa-spiro[4,5]dec-7-ene-8-boronic acid pinacol ester is used as a pharmaceutical intermediate.

Synthesis

Bis(pinacolato)diboron

73183-34-3

1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate

170011-47-9

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER

680596-79-6

1,4-Dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate (500 mg, 1.73 mmol) and pinacol bis(boronic acid) ester (530 mg, 2.08 mmol) were used as the raw materials, and 1,4-dioxane (8 mL) was used as the solvent under nitrogen protection, and potassium acetate (260 mg, 2.64 mmol) and Pd(dppf) Cl2 (130 mg, 0.17 mmol). The reaction mixture was stirred at 110 °C for 10 hours. After completion of the reaction, the insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure and purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v=2/1) to afford 540 mg of the yellow oily product 1,4-dioxa-spiro[4,5]dec-7-ene-8-boronic acid pinacol ester in 99% yield.

References

[1] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0431; 0432; 0433
[2] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 20
[3] Patent: US2008/300242, 2008, A1. Location in patent: Page/Page column 102
[4] Patent: WO2017/192811, 2017, A1. Location in patent: Paragraph 00173
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5377 - 5380

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Preparation Products And Raw materials

Raw materials

Bis(pinacolato)diboron 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate Potassium Acetate [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) 1,4-Dioxane

Preparation Products

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Suppliers

Global Suppliers ( 203)
Supplier Tel Email Country ProdList Advantage
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Hebei Maison Chemical Co.,Ltd. 155-11852758; 18408670720 ruby@maisonchem.com.cn China 687 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Supplier Advantage
Energy Chemical 58
Hebei Maison Chemical Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Topbiochem Technology Co., Ltd 58

View Latest Price from 1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER pictures 2026-09-02 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
680596-79-6
 $1.20-34.00 1kg 99% Henan Fengda Chemical Co., Ltd
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER pictures 2021-07-13 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
680596-79-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER pictures 2021-07-10 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
680596-79-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Spectrum

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER(680596-79-6)1HNMR

680596-79-6 (1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester) Related Search:

Tetrahydrofuran Isopropenylboronic acid pinacol ester Cyclohexene-1-boronic acid pinacol ester n-Butylboronic acid 1-Hexaneboronic acid
1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid trans-1-Hexenylboronic acid pinacol ester Butyldiisopropoxyborane 1-Cyclohexenylboronic acid E-2-(1-Pentenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
2-Butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane E-Hexen-1-ylboronic acid 1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester Hexylboronic acid pinacol ester

1of3

1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1,4-dioxaspiro[4.5]dec-7-en-8-ylboronate 2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene 2-(1,4-Dioxaspiro[4.5]dec-8-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PICOL ESTER 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene (1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)BORONIC ACID PINACOL ESTER 1,4-Dioxaspiro[4.5]-7-decene-8-boronic Acid Pinacol Ester 1,4-Dioxa-Spiro[4,5]Dec-7-En-8-Boronic Acid PinacoL 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspi... 1,4- dioxo spiro [4,5] decan -7- ene -8- borate pinacol ester 2-{1,4-dioxaspiro[4.5]dec-7-en-8-yl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D24870] 2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane Cyclohexenyl-4-ethylene glycol monoketal-1-boronic acid pinacol ester 1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester 1,4-Dioxaspiro[4.5]dec-7-ene-8-boronic acid pinacol ester 680596-79-6 C14H23BO4 Organic boronic acid blocks BoronicAcids