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3-Fluoro-4-methoxybenzaldehyde

3-Fluoro-4-methoxybenzaldehyde Structure
3-Fluoro-4-methoxybenzaldehyde structure
CAS No.
351-54-2
Chemical Name:
3-Fluoro-4-methoxybenzaldehyde
Synonyms
3-Fluoroanisaldehyde;3-FLUORO-4-ANISALDEHYDE;3-FLUORO-P-ANISALDEHYDE;3-fluoro-para-anisaldehyde;3-Fluoro-p-anisaldehyde>3-FLUORO-4-METHOXYBENZALDEHYDE;4-Methoxy-3-fluorobenzaldehyde;Benzaldehyde, 3-fluoro-4-methoxy-;3-Fluoro-4-methoxybenzaldehyde,98%;3-fluoro-4-methoxybenzaldehyde(SALTDATA: FREE)
CBNumber:
CB3466360
Molecular Formula:
C8H7FO2
Molecular Weight:
154.14
MDL Number:
MFCD00003349
MOL File:
351-54-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:32:38
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3-Fluoro-4-methoxybenzaldehyde Properties

Melting point 34-35 °C (lit.)
Boiling point 129-132°C 11mm
Density 1.192±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Oil
color Clear Colourless
Sensitive Air Sensitive
BRN 1942621
InChI InChI=1S/C8H7FO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3
InChIKey SOQCZBSZZLWDGU-UHFFFAOYSA-N
SMILES C(=O)C1=CC=C(OC)C(F)=C1
CAS DataBase Reference 351-54-2(CAS DataBase Reference)
FDA UNII K2CG7GUS9W
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  37/39-26-36
WGK Germany  3
Hazard Note  Irritant
HazardClass  IRRITANT, AIR SENSITIVE
HS Code  29130000
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
2 0

3-Fluoro-4-methoxybenzaldehyde price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 155586 3-Fluoro-4-methoxybenzaldehyde 99% 351-54-2 1g $89.2 2026-04-30 Buy
Sigma-Aldrich 155586 3-Fluoro-4-methoxybenzaldehyde 99% 351-54-2 5g $144 2026-04-30 Buy
TCI Chemical F0480 3-Fluoro-p-anisaldehyde >98.0%(GC) 351-54-2 1g $32 2026-04-30 Buy
TCI Chemical F0480 3-Fluoro-p-anisaldehyde >98.0%(GC) 351-54-2 5g $92 2026-04-30 Buy
Strem Chemicals 09-0016 3-Fluoro-4-methoxybenzaldehyde, min. 99% min.99% 351-54-2 25g $73 2026-04-30 Buy
Product number Packaging Price Buy
155586 1g $89.2 Buy
155586 5g $144 Buy
F0480 1g $32 Buy
F0480 5g $92 Buy
09-0016 25g $73 Buy

3-Fluoro-4-methoxybenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

white to light yellow low melting crystalline mass

Uses

3-Fluoro-4-methoxybenzaldehyde is a useful reagent in the synthesis of resveratrol derivatives as potent inhibitors of lysine specific demethylase 1 (LSD1), a therapeutic target for cancer treatment and other related diseases. Also a reagent for the synthesis of substituted pyrazolyl piperidine derivatives as antiplatelet agents with antiplatelet aggregation activity in the human body.

General Description

The nuclear magnetic resonance spectral parameters for 3-Fluoro-4-methoxybenzaldehyde has been studied.

Synthesis

3-FLUORO-4-METHOXYBENZYL ALCOHOL

96047-32-4

3-Fluoro-4-methoxybenzaldehyde

351-54-2

GENERAL METHODS: A mixed solution of (3-fluoro-4-methoxyphenyl)methanol (1 mmol), N-bromosuccinimide (NBS, 1.3 eq.), potassium acetate (KOAc, 1.5 eq.), water (H2O, 1.5 mL), and dichloromethane (CH2Cl2, 0.5 mL) was placed in a 25 mL flask and magnetically stirred for 10 hours at room temperature. Upon completion of the reaction, the reaction mixture was poured into water (10 mL) and extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by rapid column chromatography on silica gel, using petroleum ether (PE) or mixed solvent of petroleum ether/ethyl acetate (PE/EtOAc) as eluent to obtain the target product 3-fluoro-4-methoxybenzaldehyde. The structure of the product was confirmed by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR).

References

[1] Applied Organometallic Chemistry, 2016, vol. 30, # 7, p. 577 - 580
[2] Letters in Organic Chemistry, 2017, vol. 14, # 4, p. 254 - 260
[3] Molecules, 2018, vol. 23, # 8,
[4] ChemSusChem, 2017, vol. 10, # 17, p. 3497 - 3505

3-Fluoro-4-methoxybenzaldehyde Preparation Products And Raw materials

Raw materials

3-Fluoro-4-methoxybenzyl alcohol N-Bromosuccinimide Water Potassium Acetate Dichloromethane

Preparation Products

3-Fluoro-4-methoxybenzyl alcohol 3-Fluoro-4-methylbenzyl alcohol 5-fluoro-6-Methoxy-1H-indole-2-carboxylic acid 2-Propenoic acid, 3-(3-fluoro-4-methoxyphenyl)-, ethyl ester, (2E)- N-(3-Fluoro-4-methoxybenzyl)-N-methylamine
Benzenecarboximidoyl chloride, 3-fluoro-N-hydroxy-4-methoxy- 5-fluoro-2-hydroxy-4-methoxybenzaldehyde

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3-Fluoro-4-methoxybenzaldehyde Suppliers

Global( 292)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 64
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Lastest Price from 3-Fluoro-4-methoxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Fluoro-4-methoxybenzaldehyde pictures 2026-09-11 3-Fluoro-4-methoxybenzaldehyde
351-54-2
 $20.00 1KG 99% 200tons/ year Speranza Chemical Co., Ltd.
3-Fluoro-4-methoxybenzaldehyde pictures 2026-08-25 3-Fluoro-4-methoxybenzaldehyde
351-54-2
 $1.10-9.90 1KG 99% min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
3-Fluoro-4-methoxybenzaldehyde pictures 2026-03-20 3-Fluoro-4-methoxybenzaldehyde
351-54-2
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd

3-Fluoro-4-methoxybenzaldehyde Spectrum

3-Fluoro-4-methoxybenzaldehyde(351-54-2)MS3-Fluoro-4-methoxybenzaldehyde(351-54-2)1HNMR3-Fluoro-4-methoxybenzaldehyde(351-54-2)13CNMR3-Fluoro-4-methoxybenzaldehyde(351-54-2)IR13-Fluoro-4-methoxybenzaldehyde(351-54-2)IR23-Fluoro-4-methoxybenzaldehyde(351-54-2)Raman

351-54-2(3-Fluoro-4-methoxybenzaldehyde)Related Search:

3-Fluoro-4-methoxybenzoic acid 2,3-Difluoro-4-methoxybenzoic acid 3-Fluoro-4-methoxybenzoyl chloride Benzoic acid, 4-ethoxy-2,3-difluoro- (9CI) 3,5-DIFLUORO-4-METHOXYACETOPHENONE
3-Fluoro-4-methoxybenzaldehyde 4-FLUORO-2-METHOXYBENZALDEHYDE 3-FLUORO-2-METHOXYBENZALDEHYDE 3,5-Difluoro-4-methoxybenzaldehyde 2-Fluoro-6-methoxybenzaldehyde99%,2-Fluoro-6-methoxybenzaldehyde 99%,2-FLUORO-6-METHOXYBENZALDEHYDE
2-CHLORO-6-FLUORO-3-METHOXYBENZALDEHYDE 6-bromo-2-fluoro-3-methoxybenzaldehyde 2,3-Difluoro-4-methoxybenzaldehyde 2,3-Difluoro-6-methoxybenzaldehyde 2-Fluoro-5-methoxybenzaldehyde
4,5-Difluoro-2-methoxybenzaldehyde 3,5-Difluoro-4-methoxybenzoic acid 3-(3-Fluoro-4-methoxybenzoyl)propionic acid

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3-FLUORO-P-ANISALDEHYDE 3-FLUORO-4-ANISALDEHYDE 3-FLUORO-4-METHOXYBENZALDEHYDE 3-Fluoro-4-Methoxybenzaldehyde/3-Fluoro-P-Anisaldehyde/M-Fluoro-P-Anisaldehyde/ 3-fluoro-4-methoxybenzaldehyde(SALTDATA: FREE) 2-Fluoro-4-formylanisole, 3-Fluoro-p-anisaldehyde 3-Fluoroanisaldehyde 3-Fluoro-4-methoxybenzaldehyde,98% 3-fluoro-para-anisaldehyde 4-Methoxy-3-fluorobenzaldehyde 3-Fluoro-p-anisaldehyde> Benzaldehyde, 3-fluoro-4-methoxy- 351-54-2 ALDEHYDE Building Blocks C8 Carbonyl Compounds Aldehydes Organic Building Blocks Fluorine series C8-C12 Carbonyl Compounds Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Aldehydes Aryl Fluorinated Building Blocks Building Blocks C8 FINE Chemical & INTERMEDIATES Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Miscellaneous Adehydes, Acetals & Ketones Anisoles, Alkyloxy Compounds & Phenylacetates Fluorine Compounds