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dBET57

dBET57 Structure
dBET57 structure
CAS No.
1883863-52-2
Chemical Name:
dBET57
Synonyms
dBET57;dBET57 ，S0137;Dbet57, 10 mM in DMSO;DBET57;DBET 57;DBET-57;inhibit,Dbet-57,dBET 57,Inhibitor,PROTACs,Dbet57,Epigenetic Reader Domain;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide;2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide;(6S)-4-(4-Chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-, (6S)-
CBNumber:
CB34844694
Molecular Formula:
C34H31ClN8O5S
Molecular Weight:
699.18
MDL Number:
MOL File:
1883863-52-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 08:17:50
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dBET57 Properties

Density 1.60±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO: soluble
form A solid
pka 10.74±0.40(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

dBET57 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 36626 dBET57 ≥98% 1883863-52-2 1mg $32 2026-04-30 Buy
Cayman Chemical 36626 dBET57 ≥98% 1883863-52-2 5mg $141 2026-04-30 Buy
Cayman Chemical 36626 dBET57 ≥98% 1883863-52-2 10mg $248 2026-04-30 Buy
Cayman Chemical 36626 dBET57 ≥98% 1883863-52-2 25mg $426 2026-04-30 Buy
Biosynth IAD86352 dBET57 1883863-52-2 50mg $1279 2026-06-04 Buy
Product number Packaging Price Buy
36626 1mg $32 Buy
36626 5mg $141 Buy
36626 10mg $248 Buy
36626 25mg $426 Buy
IAD86352 50mg $1279 Buy

dBET57 Chemical Properties, Uses, Production

Uses

dBET57 is a BRD4 selective degrader.

in vivo

dBET57 (7.5 mg/kg, intraperitoneal injection, once daily, 2 weeks) has antitumor activity in the SK-NBE(2) xenograft mouse model[1].

Animal Model:SK-NBE(2) xenograft mouse model[1]
Dosage:7.5 mg/kg, daily, 2 weeks
Administration:Intraperitoneal injection (i.p.)
Result:Reduced tumor volume, decreased the proportion of ki-67 positive cells, increased the proportion of caspase3, had no obvious organ toxicity, and downregulated the level of ZMYND8.

IC 50

BRD4 (BD1): 500 nM (DC50)

dBET57 Preparation Products And Raw materials

Raw materials

Preparation Products

dBET57 Suppliers

Global Suppliers ( 59)
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
Bide Pharmatech Ltd. 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58

View Latest Price from dBET57 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dbet57 pictures 2026-09-10 Dbet57
1883863-52-2
 $42.00-158.00 99.44% 10g TargetMol Chemicals Inc.
  • Dbet57 pictures
  • Dbet57
    1883863-52-2
  • $42.00-158.00
  • 99.44%
  • TargetMol Chemicals Inc.

dBET57 Spectrum

dBET57(1883863-52-2)1HNMR

1883863-52-2 (dBET57) Related Search:

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[4-[[(2-aminophenyl)amino]carbonyl]phenyl]-4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)- MS645 dBET23 MT1 BET inhibitor (S)-N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide
ARV-825

1of2

dBET57 DBET57;DBET 57;DBET-57 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-, (6S)- inhibit,Dbet-57,dBET 57,Inhibitor,PROTACs,Dbet57,Epigenetic Reader Domain 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide 2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide Dbet57, 10 mM in DMSO dBET57 ，S0137 (6S)-4-(4-Chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide 1883863-52-2 C34H31ClN8O5S