JC-171 (JC171)
- CAS No.
- 2112809-98-8
- Chemical Name:
- JC-171 (JC171)
- Synonyms
- JC-171 (JC171);Benzamide, 5-chloro-N-[2-[4-[(hydroxyamino)sulfonyl]phenyl]ethyl]-2-methoxy-
- CBNumber:
- CB34844922
- Molecular Formula:
- C16H17ClN2O5S
- Molecular Weight:
- 384.83
- MDL Number:
- MFCD32708504
- MOL File:
- 2112809-98-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
JC-171 (JC171) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | MJD80998 | JC-171 | 2112809-98-8 | 25mg | $1237.25 | 2026-06-04 | Buy |
| Biosynth | MJD80998 | JC-171 | 2112809-98-8 | 50mg | $1721 | 2026-06-04 | Buy |
| ChemScene | CS-0065984 | JC-171 98.06% | 2112809-98-8 | 5mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0065984 | JC-171 98.06% | 2112809-98-8 | 10mg | $487 | 2026-06-04 | Buy |
| ChemScene | CS-0065984 | JC-171 98.06% | 2112809-98-8 | 25mg | $975 | 2026-06-04 | Buy |
JC-171 (JC171) Chemical Properties, Uses, Production
Uses
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1].
in vivo
JC-171 treatment delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE) in mouse[1].
| Animal Model: | Mice immunized subcutaneously with 200 μg Myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide emulsified in Complete Freund’s Adjuvant (CFA) on day 0 followed by injection of 200 ng of pertussis toxin. |
| Dosage: | 100 mg/kg, 10 mg/kg. |
| Administration: | IP days 0, 1 and 2; and every other days thereafter (100 mg/kg). Initiated when the clinical scores of individual mice have reached 1 (flaccid tail), and given every other day (10 mg/kg). |
| Result: | Efficiently suppressed EAE progression compared with vehicle treatment. Resulted in a substantial decrease in the frequency of MOG35–55-specific Th17 cells in the spleens and spinal cords of EAE mice. |
IC 50
NLRP3
References
[1] Chunqing Guo, et al. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201. DOI:10.1021/acschemneuro.7b00124
JC-171 (JC171) Preparation Products And Raw materials
Raw materials
Preparation Products
JC-171 (JC171) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Changzhou Yourui Pharmaceutical Technology Co., Ltd | 18168818882 | 877458914@qq.com | China | 8663 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
