2-Piperazinone
- CAS No.
- 5625-67-2
- Chemical Name:
- 2-Piperazinone
- Synonyms
- PIPERAZIN-2-ONE;PIPERAZINE-2-ONE;2-OXOPIPERAZINE;PIPERAZINONE;3-Oxopiperazine;2-Ketopiperazine;NSC 27441;2-azineone;PIPERBORNENE;AKOS BBB/413
- CBNumber:
- CB3487176
- Molecular Formula:
- C4H8N2O
- Molecular Weight:
- 100.12
- MDL Number:
- MFCD01318687
- MOL File:
- 5625-67-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 136-140 °C (lit.) |
|---|---|
| Boiling point | 164°C/5mmHg(lit.) |
| Density | 1.053±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform |
| form | Crystalline Powder |
| pka | 15.47±0.20(Predicted) |
| color | White to tan |
| Sensitive | Hygroscopic |
| Stability | Stable, but may be light and moisture sensitive. Incompatible with oxidizing agents. |
| InChI | InChI=1S/C4H8N2O/c7-4-3-5-1-2-6-4/h5H,1-3H2,(H,6,7) |
| InChIKey | IWELDVXSEVIIGI-UHFFFAOYSA-N |
| SMILES | N1CCNCC1=O |
| CAS DataBase Reference | 5625-67-2(CAS DataBase Reference) |
| FDA UNII | K9H2S9K98E |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-43 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Piperazinone price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 641065 | 2-Oxopiperazine 97% | 5625-67-2 | 1g | $32.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 641065 | 2-Oxopiperazine 97% | 5625-67-2 | 5g | $112 | 2026-04-30 | Buy |
| TCI Chemical | P1867 | 2-Piperazinone >98.0%(GC) | 5625-67-2 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | P1867 | 2-Piperazinone >98.0%(GC) | 5625-67-2 | 5g | $54 | 2026-04-30 | Buy |
| TRC | TRC-P480140-5G | 2-Piperazinone | 5625-67-2 | 5g | $300 | 2026-06-03 | Buy |
2-Piperazinone Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.
Definition
ChEBI: Piperazine-2-one is a carboximidic acid.
Synthesis
105-39-5
107-15-3
5625-67-2
The general procedure for the synthesis of 2-piperazinone from ethyl chloroacetate and ethylenediamine was as follows: ethyl chloroacetate (4.9 g, 40 mmol) was dissolved in 40 mL of anhydrous ethanol and slowly added dropwise to 100 mL of ethylenediamine (24 g, 400 mmol) over 3.5 hours at room temperature. After the dropwise addition, the reaction mixture was allowed to stand for 2 hours. Subsequently, sodium ethoxide (15 mL, 40 mmol, 21% w/w denatured ethanol solution) was added, the precipitated sodium chloride was removed by filtration and the solvent was evaporated. To the resulting red oil 40 mL of DMF was added and stirred at room temperature for 24 h. The mixture was then heated at 60°C to 70°C while N2 gas was passed through to remove volatiles. The resulting yellow solid was separated by silica gel column chromatography, eluting using a solvent mixture (CHCl3:MeOH:NH4OH = 9:1:0.1) to give the crude product (3.3 g, 33 mmol, 82% yield). This yellow solid was used directly in the next step of the reaction without further purification. Pure white crystals were obtained by three times recrystallization from acetone.1H NMR (CDCl3): δ 1.70 (1H, br s), 3.03 (2H, t, J = 5.4 Hz), 3.37 (2H, td, J = 2.3, 5.4 Hz), 3.52 (2H, s), 6.54 (1H, br s).13C NMR (CDCl3): δ 42.31, 43.05, 49.83, 170.00. melting point: 132°C-134°C (uncorrected) [literature value: 136°C (corrected)] (American Chemical Society Journal, 62 (1940) 1202-1204).
References
[1] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[2] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[3] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 80
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 1202
2-Piperazinone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Dingxin Biotechnology Co., Ltd. | 0571-88194596 15558156576 | sales@disynchem.com | China | 94 | 55 |
| Shanghai Chainpharm Bio-medical Technology Co., Ltd. | +86-021-61727342 13611721451 | sales@chainpharm.com | China | 984 | 58 |
| Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | figo.gao@foxmail.com | China | 7601 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2-Piperazinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Piperazinone
5625-67-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-06-30 | 2-Piperazinone
5625-67-2
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 2-Piperazinone
5625-67-2
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Piperazinone
5625-67-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Piperazinone
5625-67-2
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Piperazinone
5625-67-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
