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2-Piperazinone

2-Piperazinone Structure
2-Piperazinone structure
CAS No.
5625-67-2
Chemical Name:
2-Piperazinone
Synonyms
PIPERAZIN-2-ONE;2-OXOPIPERAZINE;PIPERAZINE-2-ONE;PIPERAZINONE;NSC 27441;AKOS BBB/413;PIPERBORNENE;2-piperadone;2-piperazone;2-Piperzinone
CBNumber:
CB3487176
Molecular Formula:
C4H8N2O
Molecular Weight:
100.12
MDL Number:
MFCD01318687
MOL File:
5625-67-2.mol
MSDS File:
SDS
Last updated:2026-01-13 11:19:02
Product description Number Pack Size Price
2-Oxopiperazine 97% 641065 1g $30.5
2-Oxopiperazine 97% 641065 5g $105
2-Piperazinone >98.0%(GC) P1867 1g $23
2-Piperazinone >98.0%(GC) P1867 5g $67
2-Piperazinone P480140 2g $110
More product size
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2-Piperazinone Properties

Melting point 136-140 °C (lit.)
Boiling point 164°C/5mmHg(lit.)
Density 1.053±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform
pka 15.47±0.20(Predicted)
form Crystalline Powder
color White to tan
Sensitive Hygroscopic
Stability Stable, but may be light and moisture sensitive. Incompatible with oxidizing agents.
InChI InChI=1S/C4H8N2O/c7-4-3-5-1-2-6-4/h5H,1-3H2,(H,6,7)
InChIKey IWELDVXSEVIIGI-UHFFFAOYSA-N
SMILES N1CCNCC1=O
CAS DataBase Reference 5625-67-2(CAS DataBase Reference)
FDA UNII K9H2S9K98E
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H317-H319-H335
Precautionary statements  P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38-43
Safety Statements  26-36/37
RIDADR  1759
WGK Germany  3
HazardClass  8
PackingGroup  III
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
NFPA 704
1
3 1

2-Piperazinone price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 641065 2-Oxopiperazine 97% 5625-67-2 1g $30.5 2025-07-31 Buy
Sigma-Aldrich 641065 2-Oxopiperazine 97% 5625-67-2 5g $105 2025-07-31 Buy
TCI Chemical P1867 2-Piperazinone >98.0%(GC) 5625-67-2 1g $23 2025-07-31 Buy
TCI Chemical P1867 2-Piperazinone >98.0%(GC) 5625-67-2 5g $67 2025-07-31 Buy
TRC P480140 2-Piperazinone 5625-67-2 2g $110 2021-12-16 Buy
Product number Packaging Price Buy
641065 1g $30.5 Buy
641065 5g $105 Buy
P1867 1g $23 Buy
P1867 5g $67 Buy
P480140 2g $110 Buy

2-Piperazinone Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.

Definition

ChEBI: Piperazine-2-one is a carboximidic acid.

Synthesis

Ethyl chloroacetate

105-39-5

Ethylenediamine

107-15-3

2-Piperazinone

5625-67-2

The general procedure for the synthesis of 2-piperazinone from ethyl chloroacetate and ethylenediamine was as follows: ethyl chloroacetate (4.9 g, 40 mmol) was dissolved in 40 mL of anhydrous ethanol and slowly added dropwise to 100 mL of ethylenediamine (24 g, 400 mmol) over 3.5 hours at room temperature. After the dropwise addition, the reaction mixture was allowed to stand for 2 hours. Subsequently, sodium ethoxide (15 mL, 40 mmol, 21% w/w denatured ethanol solution) was added, the precipitated sodium chloride was removed by filtration and the solvent was evaporated. To the resulting red oil 40 mL of DMF was added and stirred at room temperature for 24 h. The mixture was then heated at 60°C to 70°C while N2 gas was passed through to remove volatiles. The resulting yellow solid was separated by silica gel column chromatography, eluting using a solvent mixture (CHCl3:MeOH:NH4OH = 9:1:0.1) to give the crude product (3.3 g, 33 mmol, 82% yield). This yellow solid was used directly in the next step of the reaction without further purification. Pure white crystals were obtained by three times recrystallization from acetone.1H NMR (CDCl3): δ 1.70 (1H, br s), 3.03 (2H, t, J = 5.4 Hz), 3.37 (2H, td, J = 2.3, 5.4 Hz), 3.52 (2H, s), 6.54 (1H, br s).13C NMR (CDCl3): δ 42.31, 43.05, 49.83, 170.00. melting point: 132°C-134°C (uncorrected) [literature value: 136°C (corrected)] (American Chemical Society Journal, 62 (1940) 1202-1204).

References

[1] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[2] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[3] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 80
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 1202

2-Piperazinone Preparation Products And Raw materials

Raw materials

Ethylenediamine Ethanol Diphenyl ether Sodium Sodium ethoxide
Ethyl bromoacetate Ethyl acetate PETROLEUM ETHER Ethyl chloroacetate Ethyl diazoacetate

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Preparation Products

BAY-1163877 1-Boc-3-oxopiperazine Piperazinone, 4-(3-hydroxypropyl)- (9CI) 4-(4-bromobenzyl)piperazin-2-one 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
4-phenyl-2-piperazinone 1,4-Dioxa-8-azaspiro[4.5]decane

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2-Piperazinone Suppliers

Global( 392)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 sales8@hbganmiao.com China 300 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21599 55
Chembon Pharmaceutical Co., Ltd. 		+86-28-8425-2981 CHINA 722 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2161 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Beijing Ribio Biotech Co.,Ltd 		010-62664360 +8613328773880 wucy@ribio.com.cn China 117 58
Yunbio Tech Co.,Ltd. 		+86-010-60605551 +86-18046518538 yunbiochem@126.com China 321 58
Supplier Advantage
Hebei Ganmiao New material Technology Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Chembon Pharmaceutical Co., Ltd. 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Beijing Ribio Biotech Co.,Ltd 		58
Yunbio Tech Co.,Ltd. 		58

View Lastest Price from 2-Piperazinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Piperazinone pictures 2025-12-01 2-Piperazinone
5625-67-2
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Piperazinone pictures 2025-11-18 2-Piperazinone
5625-67-2
 US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
2-Piperazinone pictures 2025-04-04 2-Piperazinone
5625-67-2
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • 2-Piperazinone pictures
  • 2-Piperazinone
    5625-67-2
  • US $0.00-0.00 / KG
  • 98.0%
  • Shaanxi Dideu New Materials Co. Ltd
  • 2-Piperazinone pictures
  • 2-Piperazinone
    5625-67-2
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.

2-Piperazinone Spectrum

2-Piperazinone(5625-67-2)1HNMR

5625-67-2(2-Piperazinone)Related Search:

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TIMTEC-BB SBB000034 PIPERAZINONE PIPERAZIN-2-ONE PIPERAZINE-2-ONE 2-PIPERAZINONE 2-OXOPIPERZAINE 2-OXOPIPERAZINE AKOS BBS-00007028 AKOS BBB/413 CHEMBRDG-BB 4102110 2-Piperzinone Piperazin-2-one, 99+% PIPERBORNENE Piperazin-2-one ,98% 2-piperadone Piperazinone (8CI,9CI) piperazin-2-one(SALTDATA: FREE) 2-Ketopiperazine 3-Oxopiperazine NSC 27441 Oxopiperazine Tetrahydro-2(1H)-pyrazinone Piperazin-2-one 2-Oxopiperazine pyrazin-2(3H)-one 2 - piperazine ketone 2-Oxopiperazine 97% 2-oxo-piperadzine 2-Piperazinone,97% 2-piperazone 2-Piperazinone> 2-Piperazinone ISO 9001：2015 REACH Piperazin-2-one 2-Oxopiperazin 3-oxopiperazin-1-ium Piperazin-2-one, Piperazine-2-one, 2-Oxopiperazine, 2-Piperazinone, Piperazinone 5625-67-2 5626-67-2 C4H9N2O AMIDE Building Blocks Piperazines Heterocyclic Building Blocks Building Blocks C4 to C8 Chemical Synthesis Heterocyclic Building Blocks Heterocycles Miscellaneous Reagents pharmacetical Piperaizine Ketone Building Blocks Heterocyclic Building Blocks Piperazines Non-Chiral heterocyclic compounds