Glycine anhydride
- CAS No.
- 106-57-0
- Chemical Name:
- Glycine anhydride
- Synonyms
- PIPERAZINE-2,5-DIONE;Diketopiperazine;2,5-PIPERAZINEDIONE;2,5-Dioxopiperazin;Glycine EP Impurity B;c(Gly-Gly);Oxiracetam-1;Cyclodiglycine;Glycinanhydrid;CYCLO(-GLY-GLY)
- CBNumber:
- CB3356030
- Molecular Formula:
- C4H6N2O2
- Molecular Weight:
- 114.1
- MDL Number:
- MFCD00006009
- MOL File:
- 106-57-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 213.59°C (rough estimate) |
| Density | 1.3565 (rough estimate) |
| refractive index | 1.4487 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | 142g/l |
| pka | 12.88±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to slightly yellow |
| Water Solubility | Soluble in water (142mg/L). |
| Merck | 14,7466 |
| BRN | 112112 |
| InChI | 1S/C4H6N2O2/c7-3-1-5-4(8)2-6-3/h1-2H2,(H,5,8)(H,6,7) |
| InChIKey | BXRNXXXXHLBUKK-UHFFFAOYSA-N |
| SMILES | N1CC(=O)NCC1=O |
| CAS DataBase Reference | 106-57-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 240L69DTV7 |
| EPA Substance Registry System | 2,5-Piperazinedione (106-57-0) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TL6325250 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Glycine anhydride price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G7251 | Glycine anhydride cyclic dipeptide | 106-57-0 | 25g | $90.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | G7251 | Glycine anhydride cyclic dipeptide | 106-57-0 | 1kg | $1130 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.14160 | 2,5-Piperazinedione for synthesis | 106-57-0 | 25G | $161 | 2026-04-30 | Buy |
| TCI Chemical | G0100 | Glycine Anhydride >98.0%(N) | 106-57-0 | 25g | $91 | 2026-04-30 | Buy |
| TCI Chemical | G0100 | Glycine Anhydride >98.0%(N) | 106-57-0 | 500g | $726 | 2026-04-30 | Buy |
Glycine anhydride Chemical Properties, Uses, Production
Chemical Properties
white to slightly yellow crystalline powder
Uses
2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.
Definition
ChEBI: A cyclic peptide that is piperazine in which the hydrogens at positions 2 and 5 are replaced by oxo groups.
Synthesis Reference(s)
Journal of the American Chemical Society, 87, p. 4646, 1965 DOI: 10.1021/ja00948a047
Purification Methods
Recrystallise glycine anhydride from H2O (plates) and it can be sublimed (slowly) at 260o or at 140-170o/0.5mm. The dihydrochloride has m 129-130o and is prepared by dissolving it in conc HCl and adding EtOH to crystallisation point; dry it in a vacuum. The bis-1-naphthylurethane has m 232o(dec), and the diperchlorate has m 117o (hygroscopic). [MS: Johnstone J Chem Soc, Perkin Trans 1 1297 1975, NMR: Blaha & Samek Collect Czech Chem Commun 32 3780 1967, Sauborn J Phys Chem 36 179 1932, Corey J Am Chem Soc 60 1599 1938, Beilstein 24 IV 1070.]
Glycine anhydride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong INOV New Materials Co., Ltd. | 18369999171 | sales2@promisechemical.com | China | 85 | 58 |
| Xi'an Qingxiang Biotechnology Co., Ltd | 029-18192656670 18192656670 | 2557411153@qq.com | China | 189 | 58 |
| Xi 'an billiton biological technology co., LTD | 029-88764766 | wang.yali@xatuochao.com | China | 521 | 58 |
| Beijing Yibai Biotechnology Co., Ltd. | 16600087706 | shadow@yibaibiotech.com | China | 59 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from Glycine anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | GLYCINE ANHYDRIDE
106-57-0
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-05-12 | Glycine anhydride
106-57-0
|
1kg | 98% | 2 MTs | PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | ||
 |
2022-11-24 | GLYCINE ANHYDRIDE
106-57-0
|
1kg | 99% | 100tons | Shandong Promise New Material Co.,Ltd. |
-
- GLYCINE ANHYDRIDE
106-57-0
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Glycine anhydride
106-57-0
- $0.00
- 98%
- PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
-
- GLYCINE ANHYDRIDE
106-57-0
- $0.00
- 99%
- Shandong Promise New Material Co.,Ltd.
