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2,5-Dichlorothiophene

2,5-Dichlorothiophene Structure
2,5-Dichlorothiophene structure
CAS No.
3172-52-9
Chemical Name:
2,5-Dichlorothiophene
Synonyms
Metomidine base;DICHLOROTHIOPHENE;2,5-diclorothiophene;2,5-dichloro-thiophen;2,6-DICHLOROTHIOPHENE;2,5-DICHLOROTHIOPHENE;2, 5-dichlorthiophene;2,5-Dichlorothiophenene;thiophene,2,5-dichloro-;2,5-Dichlorothiophene,97%
CBNumber:
CB3664157
Molecular Formula:
C4H2Cl2S
Molecular Weight:
153.03
MDL Number:
MFCD00005423
MOL File:
3172-52-9.mol
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
2,5-Dichlorothiophene 98% D75807 25g $25.06
2,5-Dichlorothiophene 98% D75807 100g $88.3
2,5-Dichlorothiophene >97.0%(GC) D0250 25g $128
2,5-Dichlorothiophene D438880 2.5g $75
2,5-Dichlorothiophene D438880 250mg $45
More product size
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2,5-Dichlorothiophene Properties

Melting point -41--40°C
Boiling point 162 °C (lit.)
Density 1.442 g/mL at 25 °C (lit.)
refractive index 1.561-1.563
Flash point 59 °C
storage temp. 2-8°C
form liquid
color Colorless to Light yellow to Light orange
Specific Gravity 1.442
BRN 109887
InChI InChI=1S/C4H2Cl2S/c5-3-1-2-4(6)7-3/h1-2H
InChIKey FGYBDASKYMSNCX-UHFFFAOYSA-N
SMILES C1(Cl)SC(Cl)=CC=1
CAS DataBase Reference 3172-52-9(CAS DataBase Reference)
NIST Chemistry Reference Thiophene, 2,5-dichloro-(3172-52-9)
EPA Substance Registry System Thiophene, 2,5-dichloro- (3172-52-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Warning
Hazard statements  H300+H310-H300-H310-H341-H226
Precautionary statements  P210-P233-P240-P241+P242+P243-P262-P264-P270-P280-P301+P310+P330-P302+P352+P310+P361+P364-P403+P235-P405-P501-P201-P301+P310a-P303+P361+P353-P501a
Hazard Codes  T+,Xn
Risk Statements  40-26/27/28-36/37/38-20/21/22
Safety Statements  45-36/37-28A-36-26
RIDADR  2929
WGK Germany  3
TSCA  T
HazardClass  6.1
PackingGroup  II
HS Code  29349990
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
1 0

2,5-Dichlorothiophene price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D75807 2,5-Dichlorothiophene 98% 3172-52-9 25g $25.06 2025-07-31 Buy
Sigma-Aldrich D75807 2,5-Dichlorothiophene 98% 3172-52-9 100g $88.3 2025-07-31 Buy
TCI Chemical D0250 2,5-Dichlorothiophene >97.0%(GC) 3172-52-9 25g $128 2025-07-31 Buy
TRC D438880 2,5-Dichlorothiophene 3172-52-9 2.5g $75 2021-12-16 Buy
TRC D438880 2,5-Dichlorothiophene 3172-52-9 250mg $45 2021-12-16 Buy
Product number Packaging Price Buy
D75807 25g $25.06 Buy
D75807 100g $88.3 Buy
D0250 25g $128 Buy
D438880 2.5g $75 Buy
D438880 250mg $45 Buy

2,5-Dichlorothiophene Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2,5-Dichlorothiophene is mainly used as a pharmaceutical intermediate. It is used in the synthesis of 3,4-disubstituted thiophenes.

Synthesis Reference(s)

Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4

Synthesis

Thiophene(SIV) (9CI)

188290-36-0

2,5-Dichlorothiophene

3172-52-9

The general procedure for the preparation of 2,5-dichlorothiophene is as follows: 1. 300 g of carbon tetrachloride and 84 g of thiophene were added to a 1000 mL three-necked flask, heated to reflux temperature and then 270 g of N-chlorotoluene diimide was slowly added. 2. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered to remove insoluble impurities. 3. The filtrate was concentrated to recover carbon tetrachloride to give the remaining reaction mixture. 4. 4. the remaining reaction mixture was heated to 100 °C and subjected to reduced pressure distillation. 5. The 100 °C fraction was collected as the target product 2,5-dichlorothiophene in a yield of 145 g, 95% yield and 98.5% purity.

References

[1] Patent: CN105481827, 2016, A. Location in patent: Paragraph 0021; 0022
[2] Journal of Organic Chemistry, 1993, vol. 58, # 11, p. 3072 - 3075
[3] Tetrahedron, 1996, vol. 52, # 26, p. 8863 - 8866
[4] Journal of Chemical Crystallography, 2007, vol. 37, # 6, p. 387 - 398
[5] Patent: US2492644, 1947,

2,5-Dichlorothiophene Preparation Products And Raw materials

Raw materials

Thiophene(SIV) (9CI) N-Chlorosuccinimide Carbon tetrachloride

Preparation Products

ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE 2,5-Dichlorothiophene-3-sulfonyl chloride 5-Chlorothiophene-2-carboxylic acid Brinzolamide 5-CHLORO-2-THIOPHENECARBOXYLIC ACID HYDRAZIDE
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Lornoxicam 2,5-DICHLORO-3,4-DINITROTHIOPHENE 2,3,5-TRICHLOROTHIOPHENE 2,5-Dichlorothiophene-3-sulfonamide
3-Acetyl-2,5-dichlorothiophene 2-Chlorothiophene 3,4-Dichlorothiophene 5-CHLORO-2-THIOPHENECARBONITRILE 2,5-dichloro-3-(chloromethyl)thiophene

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2,5-Dichlorothiophene Suppliers

Global( 344)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3999 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29843 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49976 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hebei Yanxi Chemical Co., Ltd. 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 2,5-Dichlorothiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Dichlorothiophene pictures 2025-11-18 2,5-Dichlorothiophene
3172-52-9
 US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
2,5-DICHLOROTHIOPHENE pictures 2025-06-20 2,5-DICHLOROTHIOPHENE
3172-52-9
 US $0.00 / kg 1kg 98.00% 20tons Hebei Yanxi Chemical Co., Ltd.
2,5-Dichlorothiophene pictures 2025-04-04 2,5-Dichlorothiophene
3172-52-9
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2,5-Dichlorothiophene Spectrum

2,5-Dichlorothiophene(3172-52-9)MS2,5-Dichlorothiophene(3172-52-9)1HNMR2,5-Dichlorothiophene(3172-52-9)13CNMR2,5-Dichlorothiophene(3172-52-9)IR12,5-Dichlorothiophene(3172-52-9)Raman

3172-52-9(2,5-Dichlorothiophene)Related Search:

2,5-DICHLOROTHIOPHENE-3-SULFONAMIDE,2,5-Dichlorothiophene-3-sulfonamide ,97% 2,5-DICHLOROTHIOPHENE-3-CARBOXYLIC ACID 2,3-DICHLOROTHIOPHENE 2,5-Dichlorothiophene-3-sulfonyl chloride 3-BROMO-2,5-DICHLOROTHIOPHENE
2,4-Dichlorothieno[2,3-d]pyrimidine 2,4-DICHLOROTHIENO[3,2-D]PYRIMIDINE 2,4-Dichlorothieno[3,2-d]pyrimidine 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE,2,5-DICHLOROTHIOPHENE-3-CARBOXYLICHLORIDE 2,5-DICHLOROTHIOPHENE-3-SULFINIC ACID SODIUM SALT
4,5-Dichlorothiophene-2-sulfonamide,2,3-DICHLOROTHIOPHENE-5-SULFONAMIDE 3,4-Dichlorothiophene 2,6-DICHLOROTHIOPHENE METHYL 2,5-DICHLOROTHIOPHENE-3-CARBOXYLATE 2,3-DICHLOROTHIOPHENE-5-SULFONYL CHLORIDE,2,3-DICHLOROTHIOPHENE-5-SULPHONYL CHLORIDE
3-ACETYL-2,5-DICHLOROTHIOPHENE 3,4-DIBROMO-2,5-DICHLOROTHIOPHENE 2,5-Dichlorothiophene-3-carbaldehyde

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DICHLOROTHIOPHENE 2,5-DICHLOROTHIOPHENE 2,6-DICHLOROTHIOPHENE 2,5-dichloro-thiophen thiophene,2,5-dichloro- 2,5-Dichlorothiophenene 2,5-Dichlorothiophene,97% 5-chloro-2-thienyl chloride 2,5-Dichlorothiophene,98% 2,5- twochlorinethiophene 2,5-Dichlorothiophene > 2,5-Dichlorothiophene ISO 9001：2015 REACH Metomidine base 2, 5-dichlorthiophene 2,5-diclorothiophene 2,5-Dichlorothiophene in isooctane 3172-52-9 C4H2SCl2 C4H2Cl2S Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Thiophenes Heterocycle-oher series Halogenated Heterocycles Heterocyclic Building Blocks ThiophenesBuilding Blocks Thiophenes Organics Thiophene&Benzothiophene Miscellaneous Thiophens