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2,5-Dichlorothiophene

2,5-Dichlorothiophene Structure
2,5-Dichlorothiophene structure
CAS No.
3172-52-9
Chemical Name:
2,5-Dichlorothiophene
Synonyms
Metomidine base;DICHLOROTHIOPHENE;2,5-diclorothiophene;2,5-dichloro-thiophen;2,6-DICHLOROTHIOPHENE;2,5-DICHLOROTHIOPHENE;2, 5-dichlorthiophene;2,5-Dichlorothiophenene;thiophene,2,5-dichloro-;2,5-Dichlorothiophene,97%
CBNumber:
CB3664157
Molecular Formula:
C4H2Cl2S
Molecular Weight:
153.03
MDL Number:
MFCD00005423
MOL File:
3172-52-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:56:06
Product description Number Pack Size Price
2,5-Dichlorothiophene 98% D75807 25g $38.1
2,5-Dichlorothiophene 98% D75807 100g $94
2,5-Dichlorothiophene >97.0%(GC) D0250 25g $143
2,5-Dichlorothiophene ≥97%(GC) 44974 25G $93.34
2,5-Dichlorothiophene ≥98% AA003FV2 5g $10
More product size
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2,5-Dichlorothiophene Properties

Melting point -41--40°C
Boiling point 162 °C (lit.)
Density 1.442 g/mL at 25 °C (lit.)
refractive index 1.561-1.563
Flash point 59 °C
storage temp. 2-8°C
form liquid
Specific Gravity 1.442
color Colorless to Light yellow to Light orange
BRN 109887
InChI InChI=1S/C4H2Cl2S/c5-3-1-2-4(6)7-3/h1-2H
InChIKey FGYBDASKYMSNCX-UHFFFAOYSA-N
SMILES C1(Cl)SC(Cl)=CC=1
CAS DataBase Reference 3172-52-9(CAS DataBase Reference)
NIST Chemistry Reference Thiophene, 2,5-dichloro-(3172-52-9)
EPA Substance Registry System Thiophene, 2,5-dichloro- (3172-52-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS02,GHS06,GHS08
Signal word  Warning
Hazard statements  H300+H310-H300-H310-H341-H226
Precautionary statements  P210-P233-P240-P241+P242+P243-P262-P264-P270-P280-P301+P310+P330-P302+P352+P310+P361+P364-P403+P235-P405-P501-P201-P301+P310a-P303+P361+P353-P501a
Hazard Codes  T+,Xn
Risk Statements  40-26/27/28-36/37/38-20/21/22
Safety Statements  45-36/37-28A-36-26
RIDADR  2929
WGK Germany  3
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  II
HS Code  29349990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
1 0

2,5-Dichlorothiophene price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D75807 2,5-Dichlorothiophene 98% 3172-52-9 25g $38.1 2026-04-30 Buy
Sigma-Aldrich D75807 2,5-Dichlorothiophene 98% 3172-52-9 100g $94 2026-04-30 Buy
TCI Chemical D0250 2,5-Dichlorothiophene >97.0%(GC) 3172-52-9 25g $143 2026-04-30 Buy
Chem-Impex 44974 2,5-Dichlorothiophene ≥97%(GC) 3172-52-9 25G $93.34 2026-05-19 Buy
aablocks AA003FV2 2,5-Dichlorothiophene ≥98% 3172-52-9 5g $10 2026-05-28 Buy
Product number Packaging Price Buy
D75807 25g $38.1 Buy
D75807 100g $94 Buy
D0250 25g $143 Buy
44974 25G $93.34 Buy
AA003FV2 5g $10 Buy

2,5-Dichlorothiophene Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2,5-Dichlorothiophene is mainly used as a pharmaceutical intermediate. It is used in the synthesis of 3,4-disubstituted thiophenes.

Synthesis Reference(s)

Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4

Synthesis

Thiophene(SIV) (9CI)

188290-36-0

2,5-Dichlorothiophene

3172-52-9

The general procedure for the preparation of 2,5-dichlorothiophene is as follows: 1. 300 g of carbon tetrachloride and 84 g of thiophene were added to a 1000 mL three-necked flask, heated to reflux temperature and then 270 g of N-chlorotoluene diimide was slowly added. 2. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered to remove insoluble impurities. 3. The filtrate was concentrated to recover carbon tetrachloride to give the remaining reaction mixture. 4. 4. the remaining reaction mixture was heated to 100 °C and subjected to reduced pressure distillation. 5. The 100 °C fraction was collected as the target product 2,5-dichlorothiophene in a yield of 145 g, 95% yield and 98.5% purity.

References

[1] Patent: CN105481827, 2016, A. Location in patent: Paragraph 0021; 0022
[2] Journal of Organic Chemistry, 1993, vol. 58, # 11, p. 3072 - 3075
[3] Tetrahedron, 1996, vol. 52, # 26, p. 8863 - 8866
[4] Journal of Chemical Crystallography, 2007, vol. 37, # 6, p. 387 - 398
[5] Patent: US2492644, 1947,

2,5-Dichlorothiophene Preparation Products And Raw materials

Raw materials

Thiophene(SIV) (9CI) N-Chlorosuccinimide Carbon tetrachloride

Preparation Products

ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE 2,5-Dichlorothiophene-3-sulfonyl chloride 5-Chlorothiophene-2-carboxylic acid Brinzolamide 5-CHLORO-2-THIOPHENECARBOXYLIC ACID HYDRAZIDE
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Lornoxicam 2,5-DICHLORO-3,4-DINITROTHIOPHENE 2,3,5-TRICHLOROTHIOPHENE 2,5-Dichlorothiophene-3-sulfonamide
3-Acetyl-2,5-dichlorothiophene 2-Chlorothiophene 3,4-Dichlorothiophene 5-CHLORO-2-THIOPHENECARBONITRILE 2,5-dichloro-3-(chloromethyl)thiophene

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2,5-Dichlorothiophene Suppliers

Global( 347)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3955 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2984 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Hebei Yanxi Chemical Co., Ltd. 		+86-17531190177 faithe@yan-xi.com China 5838 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Hebei Zhanyao Biotechnology Co. Ltd 		15369953316 +8615369953316 admin@zhanyaobio.com China 2115 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 +86-18958018566 info@afinechem.com China 15058 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hebei Yanxi Chemical Co., Ltd. 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hebei Zhanyao Biotechnology Co. Ltd 		58
AFINE CHEMICALS LIMITED 		58

View Lastest Price from 2,5-Dichlorothiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Dichlorothiophene pictures 2025-11-18 2,5-Dichlorothiophene
3172-52-9
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2,5-DICHLOROTHIOPHENE pictures 2025-06-20 2,5-DICHLOROTHIOPHENE
3172-52-9
 1kg 98.00% 20tons Hebei Yanxi Chemical Co., Ltd.
2,5-Dichlorothiophene pictures 2025-04-04 2,5-Dichlorothiophene
3172-52-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2,5-Dichlorothiophene Spectrum

2,5-Dichlorothiophene(3172-52-9)MS2,5-Dichlorothiophene(3172-52-9)1HNMR2,5-Dichlorothiophene(3172-52-9)13CNMR2,5-Dichlorothiophene(3172-52-9)IR12,5-Dichlorothiophene(3172-52-9)Raman

3172-52-9(2,5-Dichlorothiophene)Related Search:

2,5-DICHLOROTHIOPHENE-3-SULFONAMIDE,2,5-Dichlorothiophene-3-sulfonamide ,97% 2,5-DICHLOROTHIOPHENE-3-CARBOXYLIC ACID 2,3-DICHLOROTHIOPHENE 2,5-Dichlorothiophene-3-sulfonyl chloride 3-BROMO-2,5-DICHLOROTHIOPHENE
2,4-Dichlorothieno[2,3-d]pyrimidine 2,4-DICHLOROTHIENO[3,2-D]PYRIMIDINE 2,4-Dichlorothieno[3,2-d]pyrimidine 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE,2,5-DICHLOROTHIOPHENE-3-CARBOXYLICHLORIDE 2,5-DICHLOROTHIOPHENE-3-SULFINIC ACID SODIUM SALT
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3-ACETYL-2,5-DICHLOROTHIOPHENE 3,4-DIBROMO-2,5-DICHLOROTHIOPHENE 2,5-Dichlorothiophene-3-carbaldehyde

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DICHLOROTHIOPHENE 2,5-DICHLOROTHIOPHENE 2,6-DICHLOROTHIOPHENE 2,5-dichloro-thiophen thiophene,2,5-dichloro- 2,5-Dichlorothiophenene 2,5-Dichlorothiophene,97% 5-chloro-2-thienyl chloride 2,5-Dichlorothiophene,98% 2,5- twochlorinethiophene 2,5-Dichlorothiophene > 2,5-Dichlorothiophene ISO 9001：2015 REACH Metomidine base 2, 5-dichlorthiophene 2,5-diclorothiophene 2,5-Dichlorothiophene in isooctane 3172-52-9 C4H2SCl2 C4H2Cl2S Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Thiophenes Heterocycle-oher series Halogenated Heterocycles Heterocyclic Building Blocks ThiophenesBuilding Blocks Thiophenes Organics Thiophene&Benzothiophene Miscellaneous Thiophens