1-Benzylpiperidine-3-carboxylic acid
- CAS No.
- 141943-04-6
- Chemical Name:
- 1-Benzylpiperidine-3-carboxylic acid
- Synonyms
- 1-Benzylpiperidine-3-carboxylic acid;N-phenylmethyl-RS-3-Piperidinecarboxylic acid;3-Piperidinecarboxylic acid, 1-(phenylmethyl)-
- CBNumber:
- CB3710476
- Molecular Formula:
- C13H17NO2
- Molecular Weight:
- 219.28
- MDL Number:
- MFCD03086172
- MOL File:
- 141943-04-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Warning |
| Hazard statements | H314 |
| Precautionary statements | P264b-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403-P501c |
| Hazard Codes | Xn |
| Risk Statements | 22 |
1-Benzylpiperidine-3-carboxylic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS3770 | 1-Benzyl-piperidine-3-carboxylic acid 97% | 141943-04-6 | 1g | $135 | 2026-06-04 | Buy |
| Activate Scientific | AS3770 | 1-Benzyl-piperidine-3-carboxylic acid 97% | 141943-04-6 | 5g | $495 | 2026-06-04 | Buy |
| aablocks | AA001HCY | 1-Benzylpiperidine-3-carboxylic acid 97% | 141943-04-6 | 250mg | $23 | 2026-05-28 | Buy |
| aablocks | AA001HCY | 1-Benzylpiperidine-3-carboxylic acid 97% | 141943-04-6 | 1g | $64 | 2026-05-28 | Buy |
| aablocks | AA001HCY | 1-Benzylpiperidine-3-carboxylic acid 97% | 141943-04-6 | 2.5g | $125 | 2026-05-28 | Buy |
1-Benzylpiperidine-3-carboxylic acid Chemical Properties, Uses, Production
Synthesis
72551-53-2
141943-04-6
The general procedure for the synthesis of 1-benzylpiperidine-3-carboxylic acid from ethyl 1-benzylpiperidine-3-carboxylate was as follows: a 4N aqueous sodium hydroxide solution (15 ml) was slowly added to a mixture of tetrahydrofuran (30 ml) and 1,4-dioxane (30 ml) containing ethyl 1-benzyl-3-piperidinecarboxylate (7.00 g, 28.3 mmol). The reaction mixture was stirred at room temperature for 4 hours. Subsequently, 4N aqueous sodium hydroxide solution (15 ml) was added again and stirring was continued at room temperature overnight. After completion of the reaction, 2N hydrochloric acid (15 ml) was slowly added to neutralize the reaction solution under ice bath cooling conditions. The neutralized mixture was azeotropically dehydrated using toluene. The obtained residue was suspended in ethanol and after filtration, the filtrate was concentrated to finally obtain 1-benzyl-3-piperidine carboxylic acid (6.3 g, 100% yield).
References
[1] Patent: EP1403255, 2004, A1. Location in patent: Page 66
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 25, p. 5512 - 5532
[3] Patent: WO2008/55959, 2008, A1. Location in patent: Page/Page column 65
1-Benzylpiperidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Benzylpiperidine-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
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| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
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