3,3'-Dithiodipropionic acid
- CAS No.
- 1119-62-6
- Chemical Name:
- 3,3'-Dithiodipropionic acid
- Synonyms
- DTDPA;3,3'-disulfanediyldipropionic acid;3,3'-dithiobispropionic acid;3,3'-disulfanediyldipropanoic acid;NSC 18841;NSC 677544;RARECHEM AL BO 1455;Dithiodipropionic aci;3,3'-Dithiodipropionic;DiThio DiPropionic Acid
- CBNumber:
- CB3723889
- Molecular Formula:
- C6H10O4S2
- Molecular Weight:
- 210.27
- MDL Number:
- MFCD00002780
- MOL File:
- 1119-62-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155-158 °C(lit.) |
|---|---|
| Boiling point | 319.8°C (rough estimate) |
| Density | 1.319 (estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Practically insoluble in water |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Powder |
| pka | 3.94±0.10(Predicted) |
| color | White |
| BRN | 1778543 |
| InChI | InChI=1S/C6H10O4S2/c7-5(8)1-3-11-12-4-2-6(9)10/h1-4H2,(H,7,8)(H,9,10) |
| InChIKey | YCLSOMLVSHPPFV-UHFFFAOYSA-N |
| SMILES | S(CCC(O)=O)SCCC(O)=O |
| CAS DataBase Reference | 1119-62-6(CAS DataBase Reference) |
| FDA UNII | 42OP5B2NI6 |
| EPA Substance Registry System | Propanoic acid, 3,3'-dithiobis- (1119-62-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 13 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3,3'-Dithiodipropionic acid price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 109010 | 3,3′-Dithiodipropionic acid 99% | 1119-62-6 | 50g | $38.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 109010 | 3,3′-Dithiodipropionic acid 99% | 1119-62-6 | 250g | $113 | 2026-04-30 | Buy |
| TCI Chemical | D0947 | 3,3'-Dithiodipropionic Acid >99.0%(GC)(T) | 1119-62-6 | 25g | $19 | 2026-04-30 | Buy |
| TCI Chemical | D0947 | 3,3'-Dithiodipropionic Acid >99.0%(GC)(T) | 1119-62-6 | 100g | $45 | 2026-04-30 | Buy |
| Usbiological | 010870 | Dithiobis-propanoic Acid | 1119-62-6 | 1g | $403 | 2026-06-03 | Buy |
3,3'-Dithiodipropionic acid Chemical Properties,Uses,Production
Preparation
Sodium hydride (1.20 g, 28.5 mmol, 57% dispersed in oil) was washed with pentane (3 × 10 ml) to remove it from the oil and suspended in 25 ml of DMF. A small amount of thiol (25 mmol) was added under a nitrogen atmosphere, and the mixture was stirred at 20°C for 15 minutes. At room temperature, a pre-weighed rubber bulb was filled with CF3I (6.5–7.0 g, 33–35 mmol, 1.3–1.4 equivalents) and fixed to the neck of the burnt vessel. The mixture immediately turned yellow and was stirred overnight at room temperature. At the end of stirring, a white precipitate formed. The slurry was poured into 200 ml of water, and the mixture was set for distillation. The product was separated by steam distillation, the organic layer was separated from the aqueous phase, the aqueous phase was extracted with diethyl ether (2 × 15 ml), the homogeneous organic phase was washed with water (3 × 10 ml), and dried over brine (10 ml) (Na2SO4). After filtration, the ether was evaporated under reduced pressure (~16 mmHg) to obtain the pure product 3,3'-Dithiodipropionic acid.
Chemical Properties
white powder
Uses
Highly reactive species.
Uses
3,3′-Dithiodipropionic acid was used as capping agent for introducing charge on gold nanoparticles surfaces.
Synthesis Reference(s)
Tetrahedron, 41, p. 2903, 1985 DOI: 10.1016/S0040-4020(01)96614-1
Chemical and Pharmaceutical Bulletin, 34, p. 486, 1986 DOI: 10.1248/cpb.34.486
General Description
3,3′-Dithiodipropionic acid forms monolayers on a polycrystalline gold electrode through a self-assembly procedure to form gold 3,3′-dithiodipropionic acid self-assembled monolayer modified electrode. It is the precursor substrate in the synthesis of 3-mercaptopropionic acid-containing polythioesters. It is added as primary carbon supplement in the culture medium of novel betaproteobacterium, strain DPN7.
Research
Besides 3MP, also the organic sulfur compounds (OSCs) 3,3'-thiodipropionic acid (TDP) and 3,3'-dithiodipropionic acid (DTDP) are established precursor substrates for poly(3HB-co-3MP) biosynthesis in R. eutropha H16. Both precursors offer advantages in comparison to 3MP. While higher concentrations of 3MP seriously impair growth of R. eutropha H16, TDP and DTDP are nontoxic OSCs[1-2].
References
[1] Christina Doberstein . “Polythioester synthesis in Ralstonia eutropha H16: Novel insights into 3,3′-thiodipropionic acid and 3,3′-dithiodipropionic acid catabolism.” Journal of biotechnology 184 (2014): Pages 187-198.
[2] Jan Hendrik Wübbeler. “Dihydrolipoamide dehydrogenases of Advenella mimigardefordensis and Ralstonia eutropha catalyze cleavage of 3,3’-dithiodipropionic acid into 3-mercaptopropionic acid.” ACS Applied Electronic Materials (2010): 7023–8.
3,3'-Dithiodipropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Huishen Chemical Co., Ltd | 021-021-56354726 15317631096 | 2936900186@qq.com | China | 19 | 58 |
| JiangSu Juming Chemical Technology Co.,Ltd | 0510-80665518 13921219871 | zhaokui@jumingchem.com | China | 30 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Donghualituo Techonlogy Development Co.,Ltd. | 010-88425576 | sales@dhltchem.com | China | 793 | 59 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Lastest Price from 3,3'-Dithiodipropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 3,3'-Disulfanediyldipropanoic acid
1119-62-6
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2026-07-28 | 3,3'-Dithiodipropionic Acid
1119-62-6
|
1KG | ≥98% | 100 tons | Xi’an Goldenfeather & One Technology Co., Ltd. | ||
 |
2026-06-30 | 3,3'-Dithiodipropionic acid
1119-62-6
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3,3'-Disulfanediyldipropanoic acid
1119-62-6
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 3,3'-Dithiodipropionic Acid
1119-62-6
- $0.00
- ≥98%
- Xi’an Goldenfeather & One Technology Co., Ltd.
-
- 3,3'-Dithiodipropionic acid
1119-62-6
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
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