TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
- CAS No.
- 3685-26-5
- Chemical Name:
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
- Synonyms
- trans-4-Hydroxycyclohexane-1-carboxylic acid;NSC7857;NSC-7857;NSC 7857;Hydroxycyclohexanecarboxylicacid;trans-1-Carboxy-4-hydroxycyclohexane;trans-4-Hydroxycyclohexylcarboxylic acid;TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;(1r,4r)-4-hydroxycyclohexanecarboxylic acid;trans-4-HydroxycyclohexanecarboxylicAcid>
- CBNumber:
- CB3727377
- Molecular Formula:
- C7H12O3
- Molecular Weight:
- 144.17
- MDL Number:
- MFCD02093477
- MOL File:
- 3685-26-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| trans-4-Hydroxycyclohexanecarboxylic Acid >97.0%(GC)(T) | H1175 | 5g | $59 |
| trans-4-Hydroxycyclohexanecarboxylic Acid >97.0%(GC)(T) | H1175 | 25g | $174 |
| trans-4-Hydroxycyclohexanecarboxylic acid | 119938 | 1.00g | $64 |
| trans-4-Hydroxycyclohexanecarboxylic acid | 119938 | 5.00g | $198 |
| trans-4-Hydroxycyclohexanecarboxylic acid | 119938 | 10.00g | $324 |
| More product size | |||
| Melting point | 145°C |
|---|---|
| Boiling point | 308℃ |
| Density | 1.246 |
| Flash point | 154℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | pK1:4.687 (25°C) |
| color | White to Off-White |
| InChI | InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6- |
| InChIKey | HCFRWBBJISAZNK-IZLXSQMJSA-N |
| SMILES | [C@@H]1(C(O)=O)CC[C@@H](O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2916200090 | |||||||||
| NFPA 704 |
|
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1175 | trans-4-Hydroxycyclohexanecarboxylic Acid >97.0%(GC)(T) | 3685-26-5 | 5g | $59 | 2026-04-30 | Buy |
| TCI Chemical | H1175 | trans-4-Hydroxycyclohexanecarboxylic Acid >97.0%(GC)(T) | 3685-26-5 | 25g | $174 | 2026-04-30 | Buy |
| Matrix Scientific | 119938 | trans-4-Hydroxycyclohexanecarboxylic acid | 3685-26-5 | 1.00g | $64 | 2026-05-18 | Buy |
| Matrix Scientific | 119938 | trans-4-Hydroxycyclohexanecarboxylic acid | 3685-26-5 | 5.00g | $198 | 2026-05-18 | Buy |
| Matrix Scientific | 119938 | trans-4-Hydroxycyclohexanecarboxylic acid | 3685-26-5 | 10.00g | $324 | 2026-05-18 | Buy |
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.
Definition
ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.
Synthesis
3618-03-9
3685-22-1
General procedure for the synthesis of cis-4-hydroxycyclohexanecarboxylic acid from methyl cis-4-hydroxycyclohexanecarboxylate: 20 g of methyl cis-4-hydroxycyclohexanecarboxylate was dissolved in 80 mL of methanol and cooled in an ice-water bath. Slowly 40mL of 5 mol/L sodium hydroxide solution was added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. After the reaction was completed, 150 mL of water was added to dilute it. The mixture was extracted twice with ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 3 with 1 mol/L HCl and extracted twice with 50 mL of ethyl acetate to combine the organic phases. The organic phase was washed twice with saturated saline in turn, dried and decolorized. After filtration, ethyl acetate was recovered by distillation under reduced pressure to give 16 g of white solid product cis-4-hydroxycyclohexanecarboxylic acid in 90% yield.
References
[1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031
TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1226 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
View Lastest Price from TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | trans-4-Hydroxycyclohexanecarboxylic Acid
3685-26-5
|
US $29.00 / mg | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-17 | trans-4-Hydroxycyclohexanecarboxylic acid
3685-26-5
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-04-04 | Trans 4-Hydroxycyclohexane carboxylic acid
3685-26-5
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- trans-4-Hydroxycyclohexanecarboxylic Acid
3685-26-5
- US $29.00 / mg
- 98.00%
- TargetMol Chemicals Inc.
-
- trans-4-Hydroxycyclohexanecarboxylic acid
3685-26-5
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Trans 4-Hydroxycyclohexane carboxylic acid
3685-26-5
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
3685-26-5(TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID)Related Search:
1of4
