trans-4-Hydroxycyclohexanecarboxylic acid
- CAS No.
- 3685-26-5
- Chemical Name:
- trans-4-Hydroxycyclohexanecarboxylic acid
- Synonyms
- trans-4-Hydroxycyclohexane-1-carboxylic acid;NSC7857;NSC 7857;NSC-7857;Hydroxycyclohexanecarboxylicacid;trans-1-Carboxy-4-hydroxycyclohexane;trans-4-Hydroxycyclohexylcarboxylic acid;trans-4-Hydroxycyclohexanecarboxylic acid;(1r,4r)-4-hydroxycyclohexanecarboxylic acid;trans-4-HydroxycyclohexanecarboxylicAcid>
- CBNumber:
- CB3727377
- Molecular Formula:
- C7H12O3
- Molecular Weight:
- 144.17
- MDL Number:
- MFCD02093477
- MOL File:
- 3685-26-5.mol
- MSDS File:
- SDS
| Melting point | 145°C |
|---|---|
| Boiling point | 308℃ |
| Density | 1.246 |
| Flash point | 154℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | pK1:4.687 (25°C) |
| color | White to Off-White |
| InChI | InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6- |
| InChIKey | HCFRWBBJISAZNK-IZLXSQMJSA-N |
| SMILES | [C@@H]1(C(O)=O)CC[C@@H](O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2916200090 | |||||||||
| NFPA 704 |
|
trans-4-Hydroxycyclohexanecarboxylic acid price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1175 | trans-4-Hydroxycyclohexanecarboxylic Acid >97.0%(GC)(T) | 3685-26-5 | 5g | $59 | 2026-04-30 | Buy |
| TCI Chemical | H1175 | trans-4-Hydroxycyclohexanecarboxylic Acid >97.0%(GC)(T) | 3685-26-5 | 25g | $174 | 2026-04-30 | Buy |
| TRC | TRC-H826900-5G | trans-4-Hydroxycyclohexylcarboxylic Acid | 3685-26-5 | 5g | $154 | 2026-06-03 | Buy |
| TRC | TRC-H826900-500MG | trans-4-Hydroxycyclohexylcarboxylic Acid | 3685-26-5 | 500mg | $73 | 2026-06-03 | Buy |
| TRC | TRC-H826900-1G | trans-4-Hydroxycyclohexylcarboxylic Acid | 3685-26-5 | 1g | $91 | 2026-06-03 | Buy |
trans-4-Hydroxycyclohexanecarboxylic acid Chemical Properties, Uses, Production
Uses
trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.
Definition
ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.
Synthesis
3618-03-9
3685-22-1
General procedure for the synthesis of cis-4-hydroxycyclohexanecarboxylic acid from methyl cis-4-hydroxycyclohexanecarboxylate: 20 g of methyl cis-4-hydroxycyclohexanecarboxylate was dissolved in 80 mL of methanol and cooled in an ice-water bath. Slowly 40mL of 5 mol/L sodium hydroxide solution was added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. After the reaction was completed, 150 mL of water was added to dilute it. The mixture was extracted twice with ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 3 with 1 mol/L HCl and extracted twice with 50 mL of ethyl acetate to combine the organic phases. The organic phase was washed twice with saturated saline in turn, dried and decolorized. After filtration, ethyl acetate was recovered by distillation under reduced pressure to give 16 g of white solid product cis-4-hydroxycyclohexanecarboxylic acid in 90% yield.
References
[1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031
trans-4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Elitechemie MediPharma Technology Co., Ltd. | 523-86810021 18921709486 | gwli@elitechemie.com | China | 499 | 65 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from trans-4-Hydroxycyclohexanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | trans-4-Hydroxycyclohexanecarboxylic acid
3685-26-5
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2026-04-22 | trans-4-Hydroxycyclohexanecarboxylic Acid
3685-26-5
|
$29.00 | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | Trans 4-Hydroxycyclohexane carboxylic acid
3685-26-5
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- trans-4-Hydroxycyclohexanecarboxylic acid
3685-26-5
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- trans-4-Hydroxycyclohexanecarboxylic Acid
3685-26-5
- $29.00
- 98.00%
- TargetMol Chemicals Inc.
-
- Trans 4-Hydroxycyclohexane carboxylic acid
3685-26-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
3685-26-5 (trans-4-Hydroxycyclohexanecarboxylic acid) Related Search:
1of4
