| Company Name: |
Ark Pharm, Inc. |
| Tel: |
847-367-3680 |
| Email: |
sales@arkpharminc.com |
|
| | trans-4-Hydroxycyclohexanecarboxylic acid Basic information |
| | trans-4-Hydroxycyclohexanecarboxylic acid Chemical Properties |
| Melting point | 145°C | | Boiling point | 308℃ | | density | 1.246 | | Fp | 154℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO, Methanol | | form | Solid | | pka | pK1:4.687 (25°C) | | color | White to Off-White | | InChI | InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6- | | InChIKey | HCFRWBBJISAZNK-IZLXSQMJSA-N | | SMILES | [C@@H]1(C(O)=O)CC[C@@H](O)CC1 |
| | trans-4-Hydroxycyclohexanecarboxylic acid Usage And Synthesis |
| Uses | trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives. | | Definition | ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid. | | Synthesis | General procedure for the synthesis of cis-4-hydroxycyclohexanecarboxylic acid from methyl cis-4-hydroxycyclohexanecarboxylate: 20 g of methyl cis-4-hydroxycyclohexanecarboxylate was dissolved in 80 mL of methanol and cooled in an ice-water bath. Slowly 40mL of 5 mol/L sodium hydroxide solution was added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. After the reaction was completed, 150 mL of water was added to dilute it. The mixture was extracted twice with ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 3 with 1 mol/L HCl and extracted twice with 50 mL of ethyl acetate to combine the organic phases. The organic phase was washed twice with saturated saline in turn, dried and decolorized. After filtration, ethyl acetate was recovered by distillation under reduced pressure to give 16 g of white solid product cis-4-hydroxycyclohexanecarboxylic acid in 90% yield. | | References | [1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031 |
| | trans-4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials |
|