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2-Chlorothiazole

2-Chlorothiazole Structure
2-Chlorothiazole structure
CAS No.
3034-52-4
Chemical Name:
2-Chlorothiazole
Synonyms
orothiazoL;2-CHLOTHIOZOLE;2-CHLOROTHIAZOLE;2-CHLOROTHIOZOLE;Thiazole, 2-chloro-;2-Chlorothiazole,97%;2-Thiazolyl Chloride;2-Chlorothiazole 96%;2-Chlorothiazole >2-CHLORO-1,3-THIAZOLE
CBNumber:
CB3752078
Molecular Formula:
C3H2ClNS
Molecular Weight:
119.57
MDL Number:
MFCD00210701
MOL File:
3034-52-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:16:04
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2-Chlorothiazole Properties

Melting point 85 °C
Boiling point 145 °C
Density 1.393 g/mL at 25 °C
refractive index n20/D1.551
Flash point 54℃
storage temp. Inert atmosphere,2-8°C
solubility soluble in Ether
pka 0.84±0.10(Predicted)
form clear liquid
color Colorless to Almost colorless
InChI InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H
InChIKey KLEYVGWAORGTIT-UHFFFAOYSA-N
SMILES S1C=CN=C1Cl
CAS DataBase Reference 3034-52-4(CAS DataBase Reference)
FDA UNII TA2DNZ4W48
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Flame (GHS02)Exclamation Mark (GHS07)
GHS05,GHS02,GHS07
Signal word  Danger
Hazard statements  H315-H319-H226-H302-H318-H335
Precautionary statements  P280-P305+P351+P338-P210-P233-P240-P241+P242+P243-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-41-22-10
Safety Statements  23-26-36/37/39-39
RIDADR  1993
WGK Germany  1
HazardClass  3
PackingGroup  Ⅲ
HS Code  2934100090
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
NFPA 704
1
2 0

2-Chlorothiazole price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2471 2-Chlorothiazole >98.0%(GC) 3034-52-4 5g $41 2026-04-30 Buy
TCI Chemical C2471 2-Chlorothiazole >98.0%(GC) 3034-52-4 25g $122 2026-04-30 Buy
Usbiological 230080 2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC) 3034-52-4 1g $184 2026-06-03 Buy
Usbiological 230080 2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC) 3034-52-4 5g $326 2026-06-03 Buy
Usbiological 230080 2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC) 3034-52-4 25g $941 2026-06-03 Buy
Product number Packaging Price Buy
C2471 5g $41 Buy
C2471 25g $122 Buy
230080 1g $184 Buy
230080 5g $326 Buy
230080 25g $941 Buy

2-Chlorothiazole Chemical Properties,Uses,Production

Application

2-Chlorothiazole is a pharmaceutical intermediate that can be prepared from 2-aminothiazole via a diazotization reaction. Literature reports that it can be used to prepare substituted tyrosine inhibitors containing zinc-binding genes, such as N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide.

Chemical Properties

Pale yellow liquid

Definition

ChEBI: 2-chlorothiazole is a member of 1,3-thiazoles and an organochlorine compound.

Reactivity Profile

Halogen atoms in the 4- and 5-positions of thiazoles exhibit different reactivities depending on the nucleophile: with methoxide ion in methanol the reactivity sequence is 5-chlorothiazole > 2-chlorothiazole > 4-chlorothiazole. In contrast, with thiophenoxide ion or piperidine in methanol, the sequence 2 > 4 > 5 is observed. With the series of alkoxide ions methoxide, ethoxide, isopropoxide and t-butoxide in the corresponding alcohol, the reactivity ratios of 4-chlorothiazole versus 2-chlorothiazole are: 0.07, 0.6, 4, 42. The nucleophilic reactivity of 2-halogenothiazoles is strongly affected by substituents: 2-chloro-5-nitrothiazole is more reactive than 2-chlorothiazole by a factor of 10.

Synthesis

Thiazole

288-47-1

2-Chlorothiazole

3034-52-4

General procedure for the synthesis of 2-chlorothiazole from thiazole: To an anhydrous THF (60 mL) solution of thiazole (5.0 g, 58.7 mmol) was added n-butyllithium (1.6 M hexane solution, 44 mL, 70.4 mmol) slowly and dropwise over a period of 20 min at -78 °C with stirring. The reaction mixture was kept at 0 °C for 15 min, followed by dropwise addition of anhydrous THF (40 mL) solution of 2,2,2-trichloroacetyl chloride (6.6 mL, 58.7 mmol) to the orange colored mixture. The reaction mixture was continued to be stirred at -78 °C for 30 min, after which the reaction was quenched with saturated ammonium chloride solution (100 mL). After extraction with ether (2 x 150 mL), the organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (0-20% ether/pentane gradient elution) to afford the target compound 2-chlorothiazole (4.95 g, isolated yield 71%).1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=4.0 Hz, 1H), 7.15 (d, J=4.0 Hz, 1H).

References

[1] Patent: WO2008/150446, 2008, A1. Location in patent: Page/Page column 29
[2] Journal of Organometallic Chemistry, 1999, vol. 588, # 2, p. 155 - 159
[3] Journal of Organometallic Chemistry, 2000, vol. 601, # 2, p. 233 - 236

2-Chlorothiazole Preparation Products And Raw materials

Raw materials

THIAZOLE N-OXIDE 4-Chlorothiazole Thiazole 2-Aminothiazole Trifluoroacetyl chloride
n-Butyllithium 5-CHLORO-THIAZOLE

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Preparation Products

2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE 2-Chloro-5-methylthiazole N-(2-Chlorophenyl)thiazol-2-amine 2-Thiazoleacetonitrile, -alpha--methyl- 2-p-tolylthiazole
N-cyclohexyl-1,3-thiazol-2-amine N-PHENYL-2-AMINOTHIAZOLE

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2-Chlorothiazole Suppliers

Global( 251)Suppliers
Supplier Tel Email Country ProdList Advantage
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Creasyn Finechem(Tianjin) Co., Ltd. 68
J & K SCIENTIFIC LTD. 76
ChemFuture PharmaTech (Jiangsu) Ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Lastest Price from 2-Chlorothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chlorothiazole pictures 2026-09-02 2-Chlorothiazole
3034-52-4
 $1.10-32.00 1kg 99% Henan Fengda Chemical Co., Ltd
2-Chlorothiazole pictures 2026-06-30 2-Chlorothiazole
3034-52-4
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chlorothiazole pictures 2025-05-23 2-Chlorothiazole
3034-52-4
 $50.00 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co Ltd

2-Chlorothiazole Spectrum

2-Chlorothiazole(3034-52-4)1HNMR2-Chlorothiazole(3034-52-4)FT-IR

3034-52-4(2-Chlorothiazole)Related Search:

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2-CHLOROTHIAZOLE 2-CHLORO-1,3-THIAZOLE 2-CHLOROTHIOZOLE 2-CHLOTHIOZOLE 2-CHLOROTHIAZOLE, 95+% 1-BENZYLPYRROLIDINE-3-CARBOXYAMIDE Thiazole, 2-chloro- 2-Chlorothiazole 96% 2-Thiazolyl Chloride 2-Chlorothiazole,97% orothiazoL 2-Chloro-1,3-thiazole 98% 2-Chlorothiazole > 3034-52-4 3034-53-4 3034-49-3 C3H2ClNS Miscellaneous Heterocycle Thiazoles, Isothiazoles & Benzothiazoles Thiazole series Halides Thiazoles, Isothiazoles &Benzothiazoles Thiazoles, Isothiazoles & Benzothiazoles