3,5-Dichlorobenzoic acid
- CAS No.
- 51-36-5
- Chemical Name:
- 3,5-Dichlorobenzoic acid
- Synonyms
- 3,5-dichlorobenzoic;BIS(TRICHORO METHYL)CARBONATE;3.5-Dichlorobe;BUTTPARK 45\07-34;RARECHEM AL BO 0040;3,5-DICHLOROBENZIC ACID;3,5-dichloro-benzoicaci;3,5-Dichlorbenzoesaeure;3,5-DICHLOROBENZOIC ACID;BENZOIC ACID, 3,5-DICHLORO-
- CBNumber:
- CB3760057
- Molecular Formula:
- C7H4Cl2O2
- Molecular Weight:
- 191.01
- MDL Number:
- MFCD00002494
- MOL File:
- 51-36-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 184-187 °C (lit.) |
|---|---|
| Boiling point | 273.68°C (rough estimate) |
| Density | 1.4410 (rough estimate) |
| refractive index | 1.4590 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.46±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | 147.1mg/L(temperature not stated) |
| BRN | 2044776 |
| InChI | InChI=1S/C7H4Cl2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,(H,10,11) |
| InChIKey | CXKCZFDUOYMOOP-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(Cl)=CC(Cl)=C1 |
| CAS DataBase Reference | 51-36-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 7BAA7R70GN |
| NIST Chemistry Reference | 3,5-Dichlorobenzoic acid(51-36-5) |
| EPA Substance Registry System | 3,5-Dichlorobenzoic acid (51-36-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG7350000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Toxicity | mouse,LD50,intraperitoneal,237mg/kg (237mg/kg),BEHAVIORAL: REGIDITYBEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY),Journal of Medicinal Chemistry. Vol. 11, Pg. 1020, 1968. | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3,5-Dichlorobenzoic acid price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D57507 | 3,5-Dichlorobenzoic acid 97% | 51-36-5 | 25g | $130 | 2026-04-30 | Buy |
| TCI Chemical | D0341 | 3,5-Dichlorobenzoic Acid >98.0%(T) | 51-36-5 | 25g | $25 | 2026-04-30 | Buy |
| TCI Chemical | D0341 | 3,5-Dichlorobenzoic Acid >98.0%(T) | 51-36-5 | 500g | $370 | 2026-04-30 | Buy |
| Usbiological | 273517 | 3,5-Dichlorobenzoic acid Asreported | 51-36-5 | 100g | $408 | 2026-06-03 | Buy |
| Usbiological | 273517 | 3,5-Dichlorobenzoic acid Asreported | 51-36-5 | 250g | $623 | 2026-06-03 | Buy |
3,5-Dichlorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White to beige powder
Physical properties
Crystals of 3,5-dichlorobenzoic acid were obtained from a water/ethanol mixture, mp186–187℃(lit. l85–187℃). Crystallization of 3,5-Dichlorobenzoic acid occurred in the monoclinic centrosymmetric space group P21/n (No. 14) with a = 3.7812(3), b = 13.996(2), and c = 14.514(2) Å, β = 95.183(8); and Z = 4. Chlorine substituents of four dimeric molecules of 3,5-Dichlorobenzoic acid formed square channels, ca. 3.54 Å on a side, which run parallel to the crystallographic a axis.
Uses
3,5-Dichlorobenzoic acid is used in organic synthesis and pesticide and pharmaceutical intermediates. It can be used to synthesize 3,5-Dichloro-N-(4-hydroxyphenethyl)benzamide and (3,5-Dichlorophenyl)-(4-fluorophenyl)methanone.
Definition
ChEBI: 3,5-dichlorobenzoic acid is a chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 3 and 5 are substituted by chloro groups. It has a role as a herbicide and a metabolite. It is a chlorobenzoic acid and a dichlorobenzene. It derives from a benzoic acid. It is a conjugate acid of a 3,5-dichlorobenzoate.
Preparation
Synthesis of 3,5-dichlorobenzoic acid: 200 parts of ethanol is slowly added to a solution, heated to 70°C, of the diazonium salt prepared as described in Example 1 from 412 parts of 3,5-dichloroanthranilic acid; elimination of nitrogen immediately takes place with evolution of heat. The mixture is stirred for another 15 minutes and 350 parts (92% of theory) of 3,5-dichlorobenzoic acid having a melting point of 176° to 178°C is isolated as described in Example 1.
Application
3,5-Dichlorobenzoic acid can be used as a pharmaceutical intermediate compound. Novel cyclopentquinoline and 3,5-dichlorobenzoic acid complexes possess antioxidant and neuroprotective effects, which can be used for the treatment of Alzheimer's disease. In addition, 3,5-Dichlorobenzoic acid has a stimulatory effect on skeletal muscle and can be used in the preparation of benzodiazepine derivatives for treating arrhythmias.
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 455, 1951 DOI: 10.1021/ja01145a145
Purification Methods
Crystallise the acid from EtOH and sublime it in a vacuum. [Beilstein 9 IV 1008.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.]
3,5-Dichlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Speranza Chemical Co., Ltd. | 0755-21030354 18126410231 | sales@speranzachem.com | China | 632 | 58 |
| Weifang QianJin Fine Chemical Co., Ltd. | 18753684562 | 1577399715@qq.COM | China | 1772 | 55 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Cangzhou Enke Pharma Tech Co.,ltd. | 0317-5106596 15533709196 | 1154424302@qq.com | China | 2502 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 15558396803 | sales@nbinno.com | China | 135 | 58 |
| Shanghai Hanlin biology science and technology co., ltd | 183-0212-4410 18302124410 | Djt18302124410@163.com | China | 2698 | 58 |
| Shandong Province zhongteng Biotechnology Co. , Ltd. | 0536-18660691112 18660691112 | 718171628@qq.com | China | 69 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
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View Lastest Price from 3,5-Dichlorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | 3,5-Dichlorobenzoic acid
51-36-5
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-11 | 3,5-Dichlorobenzoic acid
51-36-5
|
$20.00 | 1KG | 99% | 300MT/year | Speranza Chemical Co., Ltd. | |
 |
2026-06-30 | 3,5-Dichlorobenzoic acid
51-36-5
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3,5-Dichlorobenzoic acid
51-36-5
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- 3,5-Dichlorobenzoic acid
51-36-5
- $20.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 3,5-Dichlorobenzoic acid
51-36-5
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
