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CHELERYTHRINE CHLORIDE

CHELERYTHRINE CHLORIDE structure

CAS No.: 3895-92-9

Chemical Name:: CHELERYTHRINE CHLORIDE

Synonyms: Chelerythrine Chloride (NSC 646662);1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P)

CBNumber:: CB3760820

Molecular Formula:: C21H18ClNO4

Molecular Weight:: 383.82

MDL Number:: MFCD00060717

MOL File:: 3895-92-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

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CHELERYTHRINE CHLORIDE Properties

Melting point	195-205 °C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: ≥10 mg/mL
form	powder
color	yellow to orange
Water Solubility	water: 1mg/mL DMSO: 10mg/mL
Stability	Hygroscopic
InChI	1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H
InChIKey	WEEFNMFMNMASJY-UHFFFAOYSA-M
SMILES	Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC
FDA UNII	7IC98TZ0PZ
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38-36/37

Safety Statements

26-36-36/37

RIDADR

UN 1544PSN1 6.1 / PGII

WGK Germany

RTECS

FL9200000

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.

NFPA 704

	0
3		0

CHELERYTHRINE CHLORIDE price More Price(91)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0002288	Chelerythrine chloride CRS, European Pharmacopoeia (EP) Reference Standard	3895-92-9	25 mg	$127	2026-04-30	Buy
Sigma-Aldrich	C2932	Chelerythrine chloride ≥95% (TLC), powder	3895-92-9	1mg	$77.3	2026-04-30	Buy
Sigma-Aldrich	220285	Chelerythrine Chloride Naturally-occurring alkaloid.	3895-92-9	5mg	$175	2026-04-30	Buy
Sigma-Aldrich	Y0002288	Chelerythrine chloride CRS, European Pharmacopoeia (EP) Reference Standard	3895-92-9	Y0002288	$152	2024-03-01	Buy
TCI Chemical	C3584	Chelerythrine Chloride	3895-92-9	25MG	$189	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0002288	25 mg	$127	Buy
C2932	1mg	$77.3	Buy
220285	5mg	$175	Buy
Y0002288	Y0002288	$152	Buy
C3584	25MG	$189	Buy

CHELERYTHRINE CHLORIDE Chemical Properties, Uses, Production

Description

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC₅₀ = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC₅₀ = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chemical Properties

yellow to orange solid

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

General Description

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC₅₀ = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.

CHELERYTHRINE CHLORIDE synthesis

Synthesis of CHELERYTHRINE CHLORIDE from Dihydrochelerythrine

CHELERYTHRINE CHLORIDE Preparation Products And Raw materials

Raw materials

[1,3]Benzodioxolo[5,6-c]phenanthridin-13-ol, 12,13-dihydro-1,2-dimethoxy-12-methyl- 6-Oxochelerythrine

Preparation Products

Dihydrochelerythrine

CHELERYTHRINE CHLORIDE Suppliers

Global Suppliers ( 291)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Spectrum Chemical Manufacturing Corp.	021-021-021-67601398-809-809-809 15221380277	marketing_china@spectrumchemical.com	China	9643	60
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Chemsky (shanghai) International Co.,Ltd	60
Syntechem Co.,Ltd	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Spectrum Chemical Manufacturing Corp.	60
Dalian Meilun Biotech Co., Ltd.	58
Chengdu Biopurify Phytochemicals Ltd.	60

View Latest Price from CHELERYTHRINE CHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	Chelerythrine chloride 3895-92-9	$46.00-98.00		99.19%	10g	TargetMol Chemicals Inc.
2024-08-15	CHELERYTHRINE CHLORIDE 3895-92-9	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
2023-02-13	Chelerythrine chloride 3895-92-9	$80.00	1kg	99%	100MT	Hebei baicao biology science and technology co., ltd

Chelerythrine chloride
3895-92-9
$46.00-98.00
99.19%
TargetMol Chemicals Inc.

CHELERYTHRINE CHLORIDE
3895-92-9
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

Chelerythrine chloride
3895-92-9
$80.00
99%
Hebei baicao biology science and technology co., ltd

CHELERYTHRINE CHLORIDE Spectrum

CHELERYTHRINE CHLORIDE(3895-92-9)MS CHELERYTHRINE CHLORIDE(3895-92-9)¹HNMR

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TODDALIN TODDALIN CHLORIDE 3)benzodioxolo(5,6-c)phenanthridinium,1,2-dimethoxy-12-methyl-(chloride chelerythrinehydrochloride 1,2-DIMETHOXY-12,[1,3]-BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE 1,2-DIMETHOXY-12-METHYL[1,3]BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE CHELERYTHRIN CHLORIDE CHELERYTHRIN CL Chelerythrine cloride [1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride (1:1) CHELERYTHRINE CHLORIDE(RG) Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem Chelerythrine chloride,98% Chelerythrine chloride1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride Chelerythrine chloride 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride [1,3]Benzodioxolo[5,6-c]phenanthridiniuM, 1,2-diMethoxy-12-Methyl-, chloride CHELERYTHRINE CHLORIDE(P) 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride Chelerythrine Cl 17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.02,1.0,.01,1]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaen-21-ium chloride CHELERYTHRINE CHLORIDE(RG) 5mg Chelerythrine chloride-RM Chelerythrine chloride 100 μg/ml Acetonitrile Chelerythrine chloride, Cell-permeable protein kinase C inhibitor Chelerythrine chloride, 10 mM in DMSO Chelerythrine chloride (Standard) Chelerythrine Chloride (NSC 646662) 3895-92-9 16732-75-2 C21H18ClNO4 C12H18NO4 C21H18NO4Cl BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Protein Kinase C (PKC) Serine/Threonine Kinase Inhibitors antibiotic Herb extract Alkaloids Protein Kinase