SC-51089
- CAS No.
- 146033-02-5
- Chemical Name:
- SC-51089
- Synonyms
- SC-51089;SC-51089 HCl;SC-51089, EP1 receptor antagonist;2-chloro-N'-(3-(pyridin-4-yl)propanoyl)dibenzo[b,f][1,4]oxazepine-10(11H)-carbohydrazide hydrochloride;8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacid2-[1-oxo-3-(4-pyridinyl)propyl]hydrazidehydrochloride;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[1-Oxo-3-(4-pyridinyl)propyl]hydrazide Hydrochloride;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide monohydrochloride;Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, hydrochloride (1:1)
- CBNumber:
- CB3772887
- Molecular Formula:
- C22H19ClN4O3
- Molecular Weight:
- 422.86
- MDL Number:
- MFCD00869867
- MOL File:
- 146033-02-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 162-164°C |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO (25 mg/ml) or water (25 mg/mL) |
| form | White solid. |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | 6.1 | |||||||||
| NFPA 704 |
|
SC-51089 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10011561 | SC-51089 ≥95% | 146033-02-5 | 1mg | $26 | 2026-04-30 | Buy |
| Cayman Chemical | 10011561 | SC-51089 ≥95% | 146033-02-5 | 5mg | $70 | 2026-04-30 | Buy |
| Cayman Chemical | 10011561 | SC-51089 ≥95% | 146033-02-5 | 10mg | $125 | 2026-04-30 | Buy |
| Cayman Chemical | 10011561 | SC-51089 ≥95% | 146033-02-5 | 25mg | $279 | 2026-04-30 | Buy |
| Usbiological | 440088 | 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[1-Oxo-3-(4-pyridinyl)propyl]hydrazide Monohydrochloride | 146033-02-5 | 5mg | $333 | 2026-06-03 | Buy |
SC-51089 Chemical Properties,Uses,Production
Description
SC-51089 (146033-02-5) is a prostaglandin E2 (EP1 receptor) antagonist (pA2=6.5, guinea pig ileum muscle strip assay )1,4. Possesses analgesic activity in vivo (rodent ED50= 6.8 mg/kg)1,2,4. SC-51089 does not inhibit COX11 and does not block PGE1 induced hyperalgesia3.
Chemical Properties
Off-White Solid
Uses
8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide monohydrochloride is a potent and selective antagonist of EP1 receptors.
Uses
A selective EP1 prostanoid receptor antagonist that attenuates prostaglandin E2-induced neuronal cell death in vitro and slows tumor growth in vivo. Its neuroprotective effect may potentially have therapeutic application in human stroke.
Biological Activity
Selective EP 1 prostanoid receptor antagonist (K i values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μ M for EP 1 , TP, EP 3 , EP 2 , EP 4 , FP and DP receptors respectively). Attenuates PGE 2 -induced neuronal cell death in vitro and slows tumor growth in vivo .
in vivo
SC 51089 (40 μg/kg; infused i.p. for 28 d) ameliorates motor coordination and balance dysfunction and rescues long-term memory deficit in R6/1 mouse model of HD[3].
| Animal Model: | R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age[3] |
| Dosage: | 40 μg/kg/day |
| Administration: | Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system |
| Result: | Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus. |
IC 50
EP1; EP1: 1.3 μM (Ki); TP: 11.2 μM (Ki); EP3: 17.5 μM (Ki); FP: 61.1 μM (Ki)
References
[1] E. ANN. HALLINAN. N-Substituted dibenzoxazepines as analgesic PGE2 antagonists[J]. Journal of Medicinal Chemistry, 1993, 36 22: 3293-3299. DOI:10.1021/jm00074a010
[2] ANNIKA B. MALMBERG Tony L Y Michael F Rafferty. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat[J]. Neuroscience Letters, 1994, 173 1: Pages 193-196. DOI:10.1016/0304-3940(94)90181-3
[3] S.G. KHASAR. Comparison of prostaglandin E1- and prostaglandin E2-induced hyperalgesia in the rat[J]. Neuroscience, 1994, 62 2: Pages 345-350. DOI:10.1016/0306-4522(94)90369-7
[4] E. ANN HALLINAN. Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs[J]. Journal of Medicinal Chemistry, 1996, 39 2: 609-613. DOI:10.1021/jm950454k
SC-51089 Preparation Products And Raw materials
Raw materials
Preparation Products
SC-51089 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
