PROSTAGLANDIN F1ALPHA
- CAS No.
- 745-62-0
- Chemical Name:
- PROSTAGLANDIN F1ALPHA
- Synonyms
- PGF1α;PGF1α;PGF1;C06475;PGF1ALPHA;protaglandinf1;prostaglandinf1;PROSTAGLANDIN F1A;Prostaglandin F1α;PROSTAGLANDIN F1ALPHA
- CBNumber:
- CB1237881
- Molecular Formula:
- C20H36O5
- Molecular Weight:
- 356.5
- MDL Number:
- MFCD00077862
- MOL File:
- 745-62-0.mol
- MSDS File:
- SDS
| Melting point | 102.5°C |
|---|---|
| Boiling point | 409.31°C (rough estimate) |
| alpha | +24°(D/24℃)(c=0.87,THF) |
| Density | 1.0321 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | -20°C |
| solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 2 mg/ml |
| form | A crystalline solid |
| pka | 4.78±0.10(Predicted) |
| color | White to off-white |
| BRN | 2704846 |
| InChI | 1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1 |
| InChIKey | DZUXGQBLFALXCR-CDIPTNKSSA-N |
| SMILES | O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1 |
| FDA UNII | WJ72O6860W |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
PROSTAGLANDIN F1ALPHA price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15010 | Prostaglandin F1α ≥98% | 745-62-0 | 1mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 15010 | Prostaglandin F1α ≥98% | 745-62-0 | 5mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 15010 | Prostaglandin F1α ≥98% | 745-62-0 | 10mg | $445 | 2026-04-30 | Buy |
| Usbiological | 462338 | PGF1alpha (Prostaglandin F1alpha) | 745-62-0 | 1mg | $319 | 2026-06-03 | Buy |
| Usbiological | 462338 | PGF1alpha (Prostaglandin F1alpha) | 745-62-0 | 2.5mg | $460 | 2026-06-03 | Buy |
PROSTAGLANDIN F1ALPHA Chemical Properties,Uses,Production
Description
Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-
Description
Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.
PGF1α MaxSpec® standard is a quantitative grade standard of PGF1α that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGF1α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Uses
PGF1alpha (Prostaglandin F1alpha) is a smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2).
Uses
Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 1011 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.
Definition
ChEBI: Prostaglandin F1alpha is a prostaglandins Falpha. It has a role as a human metabolite.
General Description
Prostaglandins (PGs) contain prostanoic acid. They are divided as PGA, PGB, PGC, PGD, PGE and PGF groups. They all contain a five-member ring structure differing in their functions. PGF is known to be more soluble in phosphate buffer. PGF1α is a serum eicosanoid.
Biochem/physiol Actions
PGs mediate vasodilation and vasoconstriction.
References
[1] ANIL K. BALAPURE . Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor[J]. Biochemical pharmacology, 1989, 38 14: Pages 2375-2381. DOI: 10.1016/0006-2952(89)90478-4
[2] S M KARIM S R K P G Adaikan. Prostaglandins and human respiratory tract smooth muscle: structure activity relationship.[J]. Advances in prostaglandin and thromboxane research, 1980, 7: 969-980.
PROSTAGLANDIN F1ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
PROSTAGLANDIN F1ALPHA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24318 | 58 |
| amyjet | 4006800868;027-59626688 18771149750 | sales@amyjet.com | China | 2909 | 58 |
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