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(S)-N-Boc-2-Hydroxymethylmorpholine

(S)-N-Boc-2-Hydroxymethylmorpholine structure

CAS No.: 135065-76-8

Chemical Name:: (S)-N-Boc-2-Hydroxymethylmorpholine

Synonyms: tert-butyl (S)-2-(hydroxymethyl)morpholine-4-carboxylate; 135065-76-8;(S)-N-Boc-2-HydroxyMethyl...;N-Boc-(S)-3-morpholine-methanol;(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE;(S)-2-hydroxyMethyl-4-BOC-Morpholine;(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE;(S)-N-Boc-2-hydroxymethylmorpholine,99%e.e.;N-tert-Butyloxycarbonyl-(S)-2-morpholinemethanol;(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected

CBNumber:: CB3958331

Molecular Formula:: C10H19NO4

Molecular Weight:: 217.26

MDL Number:: MFCD09260606

MOL File:: 135065-76-8.mol

MSDS File:: SDS

Last updated:2026-05-28 02:50:59

Product description	Number	Pack Size	Price
(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95%	55951	1G	$29
(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95%	55951	5G	$98
(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95%	55951	25G	$298
(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected 97%	OR61432	1g	$21
(S)-N-Boc-2-Hydroxymethylmorpholine 97.0%	H11734	10g	$26
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(S)-N-Boc-2-Hydroxymethylmorpholine Properties

Melting point	60-62 °C
Boiling point	321 °C
Density	1.118
Flash point	148 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	14.36±0.10(Predicted)
form	solid
color	White
Water Solubility	Slightly soluble in water.
Sensitive	Light Sensitive
InChI	InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey	FJYBLMJHXRWDAQ-QMMMGPOBSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCO[C@H](CO)C1
CAS DataBase Reference	135065-76-8

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2933998090

NFPA 704

	1
2		0

(S)-N-Boc-2-Hydroxymethylmorpholine price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	55951	(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95%	135065-76-8	1G	$29	2026-04-30	Buy
AstaTech	55951	(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95%	135065-76-8	5G	$98	2026-04-30	Buy
AstaTech	55951	(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95%	135065-76-8	25G	$298	2026-04-30	Buy
Apolloscientific	OR61432	(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected 97%	135065-76-8	1g	$21	2026-06-04	Buy
Synthonix	H11734	(S)-N-Boc-2-Hydroxymethylmorpholine 97.0%	135065-76-8	10g	$26	2026-05-06	Buy

Product number	Packaging	Price	Buy
55951	1G	$29	Buy
55951	5G	$98	Buy
55951	25G	$298	Buy
OR61432	1g	$21	Buy
H11734	10g	$26	Buy

(S)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties,Uses,Production

Uses

(S)-N-Boc-2-hydroxymethylmorpholine is used as a pharmaceutical intermediate.

Synthesis

(S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate(WXC02979)

911223-10-4

135065-76-8

Under stirring conditions, (S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate (5.27 g, 17.2 mmol) was dissolved in 200 mL of ethanol, followed by the addition of 0.527 g of palladium/activated carbon catalyst and two drops of 1N hydrochloric acid. The reaction system was replaced three times with hydrogen and then reacted overnight at 70 °C under hydrogen atmosphere, and the reaction progress was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with 100 mL of saturated sodium bicarbonate solution and extracted with ethyl acetate (200 mL × 4). The organic phases were combined, washed sequentially with 100 mL of water and 100 mL of saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford (S)-N-Boc-2-hydroxymethylmorpholine (3.646 g, 97.7% yield) as colorless to light yellow liquid. Mass spectrum (ESI) m/z: 240.3 [M + 23]. 1H NMR (CDCl3, 400 MHz) δ 3.92-3.88 (m, 3H), 3.7-3.64 (m, 1H), 3.60-3.48 (m, 3H), 2.936 (m, 1H), 2.75 (m, 1H), 2.06 (m, 1H), 1.46 (s , 9H).

References

[1] Patent: EP2189451, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: US2010/210640, 2010, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/6715, 2007, A1. Location in patent: Page/Page column 34; 35
[4] Patent: WO2007/6714, 2007, A1. Location in patent: Page/Page column 122
[5] Patent: WO2006/105262, 2006, A1. Location in patent: Page/Page column 74; 75

(S)-N-Boc-2-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate (S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate(WXC02979) (S)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid (S)-morpholin-2-ylmethanol Water

Hydrochloric acid Ethanol Hydrogen

1of2

Preparation Products

(S)-morpholin-2-ylmethanol

(S)-N-Boc-2-Hydroxymethylmorpholine Suppliers

Global( 198)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14014	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Career Henan Chemica Co	58

View Lastest Price from (S)-N-Boc-2-Hydroxymethylmorpholine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	(S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8	$1.10	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2020-02-26	(S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8		1g	99%+	100T	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	(S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8	$1.00	1KG	98%	100KG	Career Henan Chemical Co

(S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
$1.10
99.0% Min
Dideu Industries Group Limited

(S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
$0.01
99%+
Shaanxi Dideu Medichem Co. Ltd

(S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
$1.00
98%
Career Henan Chemical Co

(S)-N-Boc-2-Hydroxymethylmorpholine Spectrum

(S)-N-Boc-2-Hydroxymethylmorpholine(135065-76-8)¹HNMR (S)-N-Boc-2-Hydroxymethylmorpholine(135065-76-8)FT-IR

135065-76-8((S)-N-Boc-2-Hydroxymethylmorpholine)Related Search:

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tert-Butyl acetate Buprofezin Tridemorph Dimethomorph Moroxydine

Tris(trimethylsilyl)phosphate (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (S)-N-Boc-2-aminomethylmorpholine (S)-1-Boc-2-(Hydroxymethyl)piperazine

3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butanol tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate

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(S)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester N-Boc-(S)-3-morpholine-methanol (S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE (2S)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (S)-N-Boc-2-HydroxyMethyl... (S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE tert-Butyl (2S)-2-(hydroxyMethyl)Morpholine-4-carboxylate 4-Morpholinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethyl ester, (2S)- (2S)-2-(Hydroxymethyl)morpholine, N-BOC protected tert-Butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate, (2S)-4-(tert-Butoxycarbonyl)-2-(hydroxymethyl)morpholine (S)-2-hydroxyMethyl-4-BOC-Morpholine (S)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine (S)-N-Boc-2-hydroxymethylmorpholine,99%e.e. 135065-76-8 ert-butyl(2S)-2-(hydroxymethyl)morpholine-4-carboxylate (S)-N-Boc-2-Hydroxymethylmorpholine ISO 9001：2015 REACH N-tert-Butyloxycarbonyl-(S)-2-morpholinemethanol tert-butyl (S)-2-(hydroxymethyl)morpholine-4-carboxylate 135065-76-8 pharmacetical API intermediates Heterocycle-other series