(S)-N-Boc-2-Hydroxymethylmorpholine
- CAS No.
- 135065-76-8
- Chemical Name:
- (S)-N-Boc-2-Hydroxymethylmorpholine
- Synonyms
- tert-butyl (S)-2-(hydroxymethyl)morpholine-4-carboxylate; 135065-76-8;(S)-N-Boc-2-HydroxyMethyl...;N-Boc-(S)-3-morpholine-methanol;(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE;(S)-2-hydroxyMethyl-4-BOC-Morpholine;(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE;(S)-N-Boc-2-hydroxymethylmorpholine,99%e.e.;N-tert-Butyloxycarbonyl-(S)-2-morpholinemethanol;(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected
- CBNumber:
- CB3958331
- Molecular Formula:
- C10H19NO4
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD09260606
- MOL File:
- 135065-76-8.mol
- MSDS File:
- SDS
| Melting point | 60-62 °C |
|---|---|
| Boiling point | 321 °C |
| Density | 1.118 |
| Flash point | 148 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 14.36±0.10(Predicted) |
| form | solid |
| color | White |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m0/s1 |
| InChIKey | FJYBLMJHXRWDAQ-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCO[C@H](CO)C1 |
| CAS DataBase Reference | 135065-76-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
(S)-N-Boc-2-Hydroxymethylmorpholine price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 55951 | (S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95% | 135065-76-8 | 1G | $29 | 2026-04-30 | Buy |
| AstaTech | 55951 | (S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95% | 135065-76-8 | 5G | $98 | 2026-04-30 | Buy |
| AstaTech | 55951 | (S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95% | 135065-76-8 | 25G | $298 | 2026-04-30 | Buy |
| Apolloscientific | OR61432 | (2S)-2-(Hydroxymethyl)morpholine, N-BOC protected 97% | 135065-76-8 | 1g | $21 | 2026-06-04 | Buy |
| Synthonix | H11734 | (S)-N-Boc-2-Hydroxymethylmorpholine 97.0% | 135065-76-8 | 10g | $26 | 2026-05-06 | Buy |
(S)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties,Uses,Production
Uses
(S)-N-Boc-2-hydroxymethylmorpholine is used as a pharmaceutical intermediate.
Synthesis
911223-10-4
135065-76-8
Under stirring conditions, (S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate (5.27 g, 17.2 mmol) was dissolved in 200 mL of ethanol, followed by the addition of 0.527 g of palladium/activated carbon catalyst and two drops of 1N hydrochloric acid. The reaction system was replaced three times with hydrogen and then reacted overnight at 70 °C under hydrogen atmosphere, and the reaction progress was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with 100 mL of saturated sodium bicarbonate solution and extracted with ethyl acetate (200 mL × 4). The organic phases were combined, washed sequentially with 100 mL of water and 100 mL of saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford (S)-N-Boc-2-hydroxymethylmorpholine (3.646 g, 97.7% yield) as colorless to light yellow liquid. Mass spectrum (ESI) m/z: 240.3 [M + 23]. 1H NMR (CDCl3, 400 MHz) δ 3.92-3.88 (m, 3H), 3.7-3.64 (m, 1H), 3.60-3.48 (m, 3H), 2.936 (m, 1H), 2.75 (m, 1H), 2.06 (m, 1H), 1.46 (s , 9H).
References
[1] Patent: EP2189451, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: US2010/210640, 2010, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/6715, 2007, A1. Location in patent: Page/Page column 34; 35
[4] Patent: WO2007/6714, 2007, A1. Location in patent: Page/Page column 122
[5] Patent: WO2006/105262, 2006, A1. Location in patent: Page/Page column 74; 75
(S)-N-Boc-2-Hydroxymethylmorpholine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Deyang Chengchuang Pharmaceutical Technology Co., Ltd. | 028-66569636 18227172063 | sales@dyccpharma.com | China | 49 | 58 |
| Chengdu Focus Pharmaceutical Technology Co., Ltd. | 028-64950838 17340131597 | wangmin@focuspharm.com | China | 750 | 58 |
| Changsha Qisheng Heyan Medical Technology Co., LTD | 18684929597 | 527907673@qq.com | China | 127 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from (S)-N-Boc-2-Hydroxymethylmorpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | (S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2020-02-26 | (S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
|
1g | 99%+ | 100T | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | (S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- (S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- (S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
- $0.01
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
-
- (S)-N-Boc-2-Hydroxymethylmorpholine
135065-76-8
- $1.00
- 98%
- Career Henan Chemical Co
