Boc-DL-3-Aminoisobutyric acid
- CAS No.
- 16948-10-0
- Chemical Name:
- Boc-DL-3-Aminoisobutyric acid
- Synonyms
- Boc-DL-3-Aminoisobutyric acid;3-(BOC-AMINO)-2-METHYLPROPANOIC ACID;REF DUPL: Boc-DL-3-Aminoisobutyric acid;3-(tert-butoxycarbonyl)-2-methylpropanoic acid;3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic;N-((tert-Butoxy)carbonyl)-DL-3-aminoisobutyric acid;3-(tert-butoxycarbonylamino)-2-methylpropanoic acid;Boc-DL-3-AMinoisobutyric acid Boc-DL-3-AMinoisobutyric acid;2-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;Propanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-Methyl-, (±)-
- CBNumber:
- CB3966754
- Molecular Formula:
- C9H17NO4
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD02094137
- MOL File:
- 16948-10-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261 |
| HazardClass | IRRITANT |
| HS Code | 2922498590 |
Boc-DL-3-Aminoisobutyric acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52205 | 3-(BOC-AMINO)-2-METHYLPROPANOIC ACID 97% | 16948-10-0 | 1G | $67 | 2026-04-30 | Buy |
| AstaTech | 52205 | 3-(BOC-AMINO)-2-METHYLPROPANOIC ACID 97% | 16948-10-0 | 5G | $237 | 2026-04-30 | Buy |
| AstaTech | 52205 | 3-(BOC-AMINO)-2-METHYLPROPANOIC ACID 97% | 16948-10-0 | 25G | $1037 | 2026-04-30 | Buy |
| Apolloscientific | OR309427 | 3-tert-Butoxycarbonylamino-2-methyl-propionic acid ≥95% | 16948-10-0 | 250mg | $44 | 2026-06-04 | Buy |
| Synthonix | B50550 | 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid 98% | 16948-10-0 | 250mg | $29 | 2026-05-06 | Buy |
Boc-DL-3-Aminoisobutyric acid Chemical Properties, Uses, Production
Uses
BOC-DL-3-aminoisobutyric acid is a product in which the amino group of 3-aminoisobutyric acid is protected by a tert-butoxycarbonyl (BOC) group, and it can be used as an intermediate in the synthesis of pharmaceuticals and chemicals.
Synthesis
10569-72-9
24424-99-5
16948-10-0
GENERAL STEPS: DL-3-aminoisobutyric acid (CAS No. [10569-72-9], 5 g, 47.52 mmol) was dissolved in 2N NaOH solution (24.7 mL), and a solution of tetrahydrofuran (THF, 75 mL) of di-tert-butyl dicarbonate (Boc2O, 11.73 g, 53.22 mmol) was added slowly dropwise with the cooling of a cold water bath, controlling the The reaction temperature was below 30 °C. The reaction mixture was stirred at room temperature for 18 hours and then concentrated under reduced pressure. The concentrate was diluted with water (75 mL) and washed with methyl tert-butyl ether (MTBE, 3 x 150 mL). The aqueous phase was acidified to pH 3 with 100 g/L citric acid solution (150 mL) and subsequently extracted with ethyl acetate (EtOAc, 3 × 150 mL). The organic phases were combined, washed with water (3×45 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 9.4 g of the target product 3-((tert-butoxycarbonyl)amino)-2-methylpropanoic acid (Compound 11) as a colorless oil in 97% yield. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6, δ, ppm): 1.01 (d, J = 7.1 Hz, 3H); 1.38 (s, 9H); 2.48 (m, 1H); 2.91 (dt, J = 6.1, 6.5 and 13.5 Hz, 1H); 3.15 (ddd, J = 6.1, 7.4 and 13.5 Hz , 1H); 6.80 (t, J = 6.1 Hz, 1H); 12.15 (broad s, 1H).
References
[1] Journal of Organic Chemistry, 2001, vol. 66, # 20, p. 6541 - 6544
[2] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 163
[3] Patent: EP2380890, 2011, A1. Location in patent: Page/Page column 19
[4] Patent: CN108341752, 2018, A. Location in patent: Paragraph 0482; 0483; 0484; 0485
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
Boc-DL-3-Aminoisobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4563 | 58 |
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2876 | 58 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
View Latest Price from Boc-DL-3-Aminoisobutyric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | Boc-DL-3-Aminoisobutyric acid
16948-10-0
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-02-02 | Boc-DL-3-Aminoisobutyric acid
16948-10-0
|
$1.00 | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- Boc-DL-3-Aminoisobutyric acid
16948-10-0
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Boc-DL-3-Aminoisobutyric acid
16948-10-0
- $1.00
- 98% HPLC
- Career Henan Chemical Co
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