L-1-Boc-Nipecotic acid
- CAS No.
- 88495-54-9
- Chemical Name:
- L-1-Boc-Nipecotic acid
- Synonyms
- (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID;BOC-(S)-NIPECOTIC ACID;(S)-1-BOC-PIPERIDINE-3-CARBOXYLIC ACID;PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;BOC-NIP;BOC-NIP-OH;(S)-BOC-NIP;BOC-L-NIP-OH;BOC-DL-NIP-OH;BOC-(S)-NIP-OH
- CBNumber:
- CB9854558
- Molecular Formula:
- C11H19NO4
- Molecular Weight:
- 229.27
- MDL Number:
- MFCD02179172
- MOL File:
- 88495-54-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 159-162 °C(lit.) |
|---|---|
| Boiling point | 353.2±35.0 °C(Predicted) |
| Density | 1.164±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 4.49±0.20(Predicted) |
| form | solid |
| color | White to off-white |
| optical activity | [α]22/D +57°, c = 1 in chloroform |
| InChI | InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1 |
| InChIKey | NXILIHONWRXHFA-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](C(O)=O)C1 |
| CAS DataBase Reference | 88495-54-9(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H410 | |||||||||
| Precautionary statements | P273-P391-P501 | |||||||||
| PPE | Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50 | |||||||||
| Safety Statements | 26-36-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 |
|||||||||
| NFPA 704 |
|
L-1-Boc-Nipecotic acid price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 681229 | (S)-1-Boc-piperidine-3-carboxylic acid 97% | 88495-54-9 | 500mg | $107 | 2026-04-30 | Buy |
| Usbiological | 261872 | N-Boc-(S)-Nipecotic acid Asreported | 88495-54-9 | 1g | $322 | 2026-06-03 | Buy |
| Usbiological | 261872 | N-Boc-(S)-Nipecotic acid Asreported | 88495-54-9 | 2g | $423 | 2026-06-03 | Buy |
| Usbiological | 261872 | N-Boc-(S)-Nipecotic acid Asreported | 88495-54-9 | 5g | $575 | 2026-06-03 | Buy |
| Usbiological | 261872 | N-Boc-(S)-Nipecotic acid Asreported | 88495-54-9 | 10g | $758 | 2026-06-03 | Buy |
L-1-Boc-Nipecotic acid Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
1-Boc-L-nipecotic acid is used as an organic chemical synthesis intermediate.
Synthesis
24424-99-5
498-95-3
71381-75-4
The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid was as follows: 1. To a solution of piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butanol (464.0 mL) was slowly added 1N NaOH solution (464.0 mL) at 0 °C and stirred for 10 min. 2. Di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was then added. 3. The reaction mixture was stirred continuously at room temperature for 12 hours. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and then neutralized to neutrality with 1N HCl solution. 5. The precipitated solid product was collected by filtration and dried to give 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1, 86.0 g, 97% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
L-1-Boc-Nipecotic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Chengdu Aminotp Pharmaceutical Technology Co.,Ltd. | 028-85755578 18140172005 | sales@aminotp.com | China | 296 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from L-1-Boc-Nipecotic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | L-1-Boc-Nipecotic acid
88495-54-9
|
$1.00 | 300g | 99.8% | 20 TONS | .GZ HONESTCHEM CO.,LTD | |
 |
2026-06-30 | L-1-Boc-Nipecotic acid
88495-54-9
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-07-02 | L-1-Boc-Nipecotic acid
88495-54-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- L-1-Boc-Nipecotic acid
88495-54-9
- $1.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- L-1-Boc-Nipecotic acid
88495-54-9
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- L-1-Boc-Nipecotic acid
88495-54-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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