CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE
- CAS No.
- 160754-76-7
- Chemical Name:
- CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE
- Synonyms
- CNS5161;CNS 5161;N-(2-Chloro-5-methylthiophenyl)-N''-(3-methylthiophenyl)-N''-methylguanidine;Guanidine, N''-[2-chloro-5-(methylthio)phenyl]-N-methyl-N-[3-(methylthio)phenyl]-;CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE
- CBNumber:
- CB41011159
- Molecular Formula:
- C16H18ClN3S2
- Molecular Weight:
- 351.92
- MDL Number:
- MFCD09833785
- MOL File:
- 160754-76-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CNS-5161 95.00% | KIN0001141 | 5MG | $503.23 |
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE Properties
| Boiling point | 465.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| pka | 10.22±0.10(Predicted) |
| FDA UNII | 58S83M36V6 |
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE Chemical Properties,Uses,Production
Chemical Properties
Yellowish oil
Uses
CNS-5161 is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
in vivo
In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1].
References
[1] Walters MR, et al. Early clinical experience with the novel NMDA receptor antagonist CNS 5161. Br J Clin Pharmacol. 2002 Mar;53(3):305-11. DOI:10.1046/j.0306-5251.2001.01541.x
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
