3-Deazauridine
- CAS No.
- 23205-42-7
- Chemical Name:
- 3-Deazauridine
- Synonyms
- NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
- CBNumber:
- CB4125871
- Molecular Formula:
- C10H13NO6
- Molecular Weight:
- 243.21
- MDL Number:
- MFCD00006522
- MOL File:
- 23205-42-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 233-235°C |
|---|---|
| Boiling point | 569.2±50.0 °C(Predicted) |
| Density | 1.718±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 4.50±1.00(Predicted) |
| color | White to Pale Beige |
| optical activity | 35.3°(C=1.00g/100ml H2O) |
| InChI | InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3 |
| InChIKey | CBOKZNLSFMZJJA-FNMQVXAUNA-N |
| SMILES | [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r| |
| LogP | -1.693 (est) |
| FDA UNII | 263CU738ZY |
| NCI Drug Dictionary | 3-deazauridine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P302+P352-P305+P351+P338 |
| RTECS | UV1148000 |
3-Deazauridine price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23125 | 3-Deazauridine ≥98% | 23205-42-7 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 23125 | 3-Deazauridine ≥98% | 23205-42-7 | 10mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 23125 | 3-Deazauridine ≥98% | 23205-42-7 | 25mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 23125 | 3-Deazauridine ≥98% | 23205-42-7 | 50mg | $268 | 2026-04-30 | Buy |
| Usbiological | 295996 | 3-Deazauridine Asreported | 23205-42-7 | 50mg | $566 | 2026-06-03 | Buy |
3-Deazauridine Chemical Properties,Uses,Production
Description
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].
Uses
Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.
Definition
ChEBI: 3-Deazauridine is a N-glycosyl compound.
in vivo
3-Deazauridine (DAUR) (250 mg/kg/day; i.p; 1-9 days) shows moderate activity against L1210 leukemia cells in mice[1].
3-Deazauridine (ip; 5 times doses) has the lethal dose of 250 mg/kg/day and 417 mg/kg/day, the toxic dose low of 62.5 mg/kg/day and 104 mg/kg/day, the highest non-toxic dose of 31.25 mg/kg/day and 52 mg/kg/day, in beagle dogs and rhesus monkeys, respectively[1].
References
[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.
3-Deazauridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Deazauridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Granlen Sciences, ltd. | 0371-85513397 +86-18610099868 | info@granlen.com | China | 1890 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Zhengzhou GranLen pharmaceutical Technology Co., Ltd. | 0371-85513397 | info@granlen.com | China | 497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
View Lastest Price from 3-Deazauridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 3-Deazauridine
23205-42-7
|
$48.00-118.00 | 99.86% | 10g | TargetMol Chemicals Inc. |
-
- 3-Deazauridine
23205-42-7
- $48.00-118.00
- 99.86%
- TargetMol Chemicals Inc.
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