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ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-

Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-

Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- Structure
Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- structure
CAS No.
2417995-08-3
Chemical Name:
Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-
Synonyms
COX-2-IN-23;Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-
CBNumber:
CB412676723
Molecular Formula:
C24H25N5O3S2
Molecular Weight:
495.62
MDL Number:
MOL File:
2417995-08-3.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
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Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- Properties

Boiling point 651.3±65.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
pka 5.03±0.20(Predicted)

Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- Chemical Properties, Uses, Production

Uses

COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

in vivo

COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer[1].

Animal Model:Mature male albino rats[1]
Dosage:9 mg/kg
Administration:Intraperitoneal injection; 0, 1, 2, 3 and 4 hours.
Result:Had similar ulcerogenic activity to celecoxib.

IC 50

COX-2: 0.28 μM (IC50); COX-1: 20.14 μM (IC50)

References

[1] Ibrahim TS, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878. DOI:10.1016/j.bioorg.2020.103878

Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9780 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
COX-2-IN-23 pictures 2026-04-21 COX-2-IN-23
2417995-08-3
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • COX-2-IN-23 pictures
  • COX-2-IN-23
    2417995-08-3
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

2417995-08-3 (Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-) Related Search:

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Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy- COX-2-IN-23 2417995-08-3