ChemicalBook >> CAS DataBase List >>Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) structure

CAS No.: 2140807-20-9

Chemical Name:: Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)

Synonyms: Poma-PEG1-COOH TFA;Thalidomide-4-NH-PEG1-COOH (TFA);3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid;2,2,2-Trifluoroacetic acid-3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid (1/1);Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)

CBNumber:: CB412835641

Molecular Formula:: C20H20F3N3O9

Molecular Weight:: 503.39

MDL Number:

MOL File:: 2140807-20-9.mol

MSDS File:: SDS

Last updated:2026-05-28 02:02:20

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Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ACHEMBLOCK	AD268278	3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid;2,2,2-trifluoroacetic acid 95%	2140807-20-9	25MG	$480	2026-05-27	Buy
ACHEMBLOCK	AD268278	3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid;2,2,2-trifluoroacetic acid 95%	2140807-20-9	100MG	$1250	2026-05-27	Buy

Product number	Packaging	Price	Buy
AD268278	25MG	$480	Buy
AD268278	100MG	$1250	Buy

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Chemical Properties, Uses, Production

Uses

Thalidomide-4-NH-PEG1-COOH TFA is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-4-NH-PEG1-COOH TFA acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-4-NH-PEG1-COOH TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

IC 50

Cereblon

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.[Content Brief] DOI:10.1038/nature13527

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Suppliers

Global Suppliers ( 14)

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI FDC-CHEMICAL CO.,LTD	021-61469567 13774476675	sales@fdc-chemical.com	China	10000	58
CR Corporation Limited		fred.wen@crcorporation.cn	China	8642	58
Hubei Kele Fine Chemical Co., Ltd	027-59101668 19945030958	2223443625@qq.com	China	7998	58
Wuhan Augda Biotechnology Co., Ltd	15071299552	262933239@qq.com	China	7201	58
Shanghai Huici Pharmaceutical Technology Co., LTD	133-31922809 19372841038	lixing@pharmahuici.com	China	853	58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.	+86-027-59232304 15387063101	1276242629@qq.com	China	9977	58
Yutong Pharmaceutical Technology (Suzhou) Co., Ltd.	0512-15851462628 15851462628	2680463261@qq.com	China	4996	58
Aikon International Limited	17714375163	hywu@aikonchem.com	China	9974	58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	18171815831	1341138380@qq.com	China	4573	58
Suzhou Haiben Pharmaceutical Co., Ltd	19353112242	1816280386@qq.com	China	8041	58

Supplier	Advantage
SHANGHAI FDC-CHEMICAL CO.,LTD	58
CR Corporation Limited	58
Hubei Kele Fine Chemical Co., Ltd	58
Wuhan Augda Biotechnology Co., Ltd	58
Shanghai Huici Pharmaceutical Technology Co., LTD	58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.	58
Yutong Pharmaceutical Technology (Suzhou) Co., Ltd.	58
Aikon International Limited	58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	58
Suzhou Haiben Pharmaceutical Co., Ltd	58

2140807-20-9 (Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)) Related Search:

1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Pomalidomide-NH-PEG3-azide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Poma-NH-C4-N3 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG2-CO2H Pomalidomide-PEG4-CO2H Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1)

4-((5-azidopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG3-CO2H 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]- E3 ligase Ligand-Linker Conjugates 50

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Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) 3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid Thalidomide-4-NH-PEG1-COOH (TFA) Poma-PEG1-COOH TFA 2,2,2-Trifluoroacetic acid-3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid (1/1) 2140807-20-9 C20H20F3N3O9