geninthiocin
- CAS No.
- 158792-27-9
- Chemical Name:
- geninthiocin
- Synonyms
- geninthiocin;Geninthiocin A;PubChem ID: 16129809;14-DeMethylberinaMycin;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
- CBNumber:
- CB41333237
- Molecular Formula:
- C50H49N15O15S
- Molecular Weight:
- 1132.08
- MDL Number:
- MOL File:
- 158792-27-9.mol
| Product description | Number | Pack Size | Price |
| Geninthiocin A | 28125 | 500μg | $323 |
| Geninthiocin A | 28125 | 2.5mg | $1127 |
| Geninthiocin | G2024-66 | 500ug | $523 |
| Geninthiocin | G350058 | 500μg | $295 |
| GENINTHIOCIN 95.00% | API0019325 | 0.5MG | $549 |
| More product size | |||
geninthiocin price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28125 | Geninthiocin A | 158792-27-9 | 500μg | $323 | 2024-03-01 | Buy |
| Cayman Chemical | 28125 | Geninthiocin A | 158792-27-9 | 2.5mg | $1127 | 2024-03-01 | Buy |
| Usbiological | G2024-66 | Geninthiocin | 158792-27-9 | 500ug | $523 | 2021-12-16 | Buy |
| TRC | G350058 | Geninthiocin | 158792-27-9 | 500μg | $295 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0019325 | GENINTHIOCIN 95.00% | 158792-27-9 | 0.5MG | $549 | 2021-12-16 | Buy |
geninthiocin Chemical Properties,Uses,Production
Description
Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.
Uses
Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
Uses
Geninthiocin is a thiopeptide antibiotic tipA gene activator.
References
[1] B S YUN. Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.[J]. Journal of Antibiotics, 1994, 47 9: 969-975. DOI: 10.7164/antibiotics.47.969
[2] APPADURAI MUTHAMIL INIYAN. Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19[J]. Journal of Antibiotics, 2018, 72 2: 99-105. DOI: 10.1038/s41429-018-0115-2
geninthiocin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8860 | 58 |
View Lastest Price from geninthiocin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-05 | Geninthiocin A
158792-27-9
|
US $791.00 / μg | 10g | TargetMol Chemicals Inc. |
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- Geninthiocin A
158792-27-9
- US $791.00 / μg
- TargetMol Chemicals Inc.
