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geninthiocin

geninthiocin Structure
geninthiocin structure
CAS No.
158792-27-9
Chemical Name:
geninthiocin
Synonyms
geninthiocin;Geninthiocin A;PubChem ID: 16129809;14-DeMethylberinaMycin;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
CBNumber:
CB41333237
Molecular Formula:
C50H49N15O15S
Molecular Weight:
1132.08
MDL Number:
MOL File:
158792-27-9.mol
MSDS File:
SDS
Last updated:2026-05-11 15:21:01
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geninthiocin Properties

Density 1.54±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: soluble; DMSO: soluble; Ethanol: slightly soluble
form White to off-white amorphous powder.
pka 10.01±0.60(Predicted)

geninthiocin price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28125 Geninthiocin A ≥95% 158792-27-9 500μg $356 2026-04-30 Buy
Cayman Chemical 28125 Geninthiocin A ≥95% 158792-27-9 2.5mg $1240 2026-04-30 Buy
Usbiological G2024-66 Geninthiocin (14-Demethylberinamycin) >95%byHPLC 158792-27-9 500ug $523 2026-06-03 Buy
Usbiological 451132 Geninthiocin 158792-27-9 500ug $631 2026-06-03 Buy
Usbiological 451132 Geninthiocin 158792-27-9 1000ug $927 2026-06-03 Buy
Product number Packaging Price Buy
28125 500μg $356 Buy
28125 2.5mg $1240 Buy
G2024-66 500ug $523 Buy
451132 500ug $631 Buy
451132 1000ug $927 Buy

geninthiocin Chemical Properties, Uses, Production

Description

Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.

Uses

Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Uses

Geninthiocin is a thiopeptide antibiotic tipA gene activator.

References

[1] B S YUN. Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.[J]. Journal of Antibiotics, 1994, 47 9: 969-975. DOI: 10.7164/antibiotics.47.969
[2] APPADURAI MUTHAMIL INIYAN. Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19[J]. Journal of Antibiotics, 2018, 72 2: 99-105. DOI: 10.1038/s41429-018-0115-2

geninthiocin Preparation Products And Raw materials

Raw materials

Preparation Products

geninthiocin Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Lynnchem 86-(0)29-85992781 17792393971 info@lynnchem.com China 4578 58
Novachemistry 44-20819178-90 02081917890 info@novachemistry.com United Kingdom 4372 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829 sales@mitachieve.com China 8857 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Lynnchem 58
Novachemistry 58
Shanghai Hongye Biotechnology Co. Ltd 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Meng Cheng Technology (Shanghai) Co., LTD 58
Zhejiang Huida Biotech Co., LTD 58
Energy Chemical 58

View Latest Price from geninthiocin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Geninthiocin A pictures 2026-05-11 Geninthiocin A
158792-27-9
 $791.00 10g TargetMol Chemicals Inc.

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geninthiocin 14-DeMethylberinaMycin PubChem ID: 16129809 Geninthiocin A Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-... 158792-27-9 C50H49N15O15S