pristimerin
- CAS No.
- 1258-84-0
- Chemical Name:
- pristimerin
- Synonyms
- pristimerin;Pristimerine;Pristimerin-RM;Celastrol-methylether;Pristimerin(NSC 99281);Celastrol methyl ester;Pristimerin (Standard);Pristimerin - CAS 1258-84-0 - Calbiochem;3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester;3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester
- CBNumber:
- CB41360260
- Molecular Formula:
- C30H40O4
- Molecular Weight:
- 464.64
- MDL Number:
- MFCD01711331
- MOL File:
- 1258-84-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 219.5°C |
|---|---|
| Boiling point | 488.1°C (rough estimate) |
| Density | 1.0271 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: ≥5mg/mL |
| form | Red solid |
| pka | 8.60±0.70(Predicted) |
| color | orange |
| InChIKey | JFACETXYABVHFD-VXTIGNJVNA-N |
| SMILES | [C@]12(C)CC[C@@]3(C)CC[C@@](C)(C(=O)OC)C[C@@]3([H])[C@]1(C)CC[C@@]1(C)C3=CC(C(O)=C(C)C3=CC=C21)=O |&1:0,4,8,15,17,21,r| |
| FDA UNII | 28ZK7PR57S |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 oral in mouse: 8gm/kg |
pristimerin price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0020 | Pristimerin ≥98% (HPLC) | 1258-84-0 | 5mg | $265 | 2026-04-30 | Buy |
| Sigma-Aldrich | 530070 | Pristimerin | 1258-84-0 | 5mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 13621 | Pristimerin ≥98% | 1258-84-0 | 5mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 13621 | Pristimerin ≥98% | 1258-84-0 | 10mg | $203 | 2026-04-30 | Buy |
| Cayman Chemical | 13621 | Pristimerin ≥98% | 1258-84-0 | 25mg | $454 | 2026-04-30 | Buy |
pristimerin Chemical Properties, Uses, Production
Description
Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-
Chemical Properties
Red crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.
Uses
antineoplastic, antiinflammatory
Uses
Pristimerin is a triterpenoid that inhibits tumor angiogenesis by targeting VEGFR2 activation and is known to exhibit anti-inflammatory properties.
Definition
ChEBI: Pristimerin is a carboxylic ester.
General Description
A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC50 = 2.2 and 3.0 μM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC50 ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC50 = 93 nM).
Biological Activity
Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC 50 = 93 nM). Also suppresses NF- κ B activation via inhibition of proteasome chymotrypsin-like activity and IKK α / β . Displays antitumor, anti-inflammatory and antimicrobial activities.
References
[1] ALVIN R KING. Discovery of potent and reversible monoacylglycerol lipase inhibitors.[J]. Chemistry & biology, 2009, 16 10: 1045-1052. DOI: 10.1016/j.chembiol.2009.09.012
pristimerin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huzhou ZhanShu Biotechnology Co.,Ltd | 0572-8889530 18167260939 | zsubio@163.com | China | 412 | 58 |
| Nanjing Spring & Autumn Biological Engineering Co., Ltd. | 17388075642 13815430202 | sale02@cqherb.com | China | 261 | 59 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
View Latest Price from pristimerin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Pristimerin
1258-84-0
|
$33.00-129.00 | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-24 | Pristimerin
1258-84-0
|
1KG | 99.0% | 10000KG | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-06-20 | Pristimerin
1258-84-0
|
$40.00 | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Pristimerin
1258-84-0
- $33.00-129.00
- 99.79%
- TargetMol Chemicals Inc.
-
- Pristimerin
1258-84-0
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Pristimerin
1258-84-0
- $40.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
