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2-Chloro-4-(trifluoromethyl)pyrimidine

2-Chloro-4-(trifluoromethyl)pyrimidine Structure
2-Chloro-4-(trifluoromethyl)pyrimidine structure
CAS No.
33034-67-2
Chemical Name:
2-Chloro-4-(trifluoromethyl)pyrimidine
Synonyms
IFLAB-BB F13;BUTTPARK 27\08-69;2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE;4-(TRIFLUOROMETHYL)-2-CHLOROPYRIMIDINE;Pyrimidine, 2-chloro-4-(trifluoromethyl)-;2-Chloro-4-(trifluoromethyl)pyrimidine99%;2-Chloro-4-(trifluoromethyl)pyrimidine 99%;2-Chloro-4-(trifluoromethyl)pyrimidine >2-Chloro-4-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH
CBNumber:
CB1107717
Molecular Formula:
C5H2ClF3N2
Molecular Weight:
182.53
MDL Number:
MFCD00115111
MOL File:
33034-67-2.mol
MSDS File:
SDS
Last updated:2026-05-20 15:44:34
Product description Number Pack Size Price
2-Chloro-4-(trifluoromethyl)pyrimidine 99% 407070 1g $28.5
2-Chloro-4-(trifluoromethyl)pyrimidine 99% 407070 5g $42.9
2-Chloro-4-(trifluoromethyl)pyrimidine >98.0%(GC) C2467 1g $46
2-Chloro-4-(trifluoromethyl)pyrimidine >98.0%(GC) C2467 5g $155
2-Chloro-4-(trifluoromethyl)pyrimidine 008885 25.00g $28
More product size
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2-Chloro-4-(trifluoromethyl)pyrimidine Properties

Boiling point 60 °C10 mm Hg(lit.)
Density 1.513 g/mL at 25 °C(lit.)
refractive index n20/D 1.447(lit.)
Flash point 120 °F
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Very Slightly)
pka -3.98±0.20(Predicted)
form Liquid
color Clear colorless to light yellow
Specific Gravity 1.5130
InChI 1S/C5H2ClF3N2/c6-4-10-2-1-3(11-4)5(7,8)9/h1-2H
InChIKey FZRBTBCCMVNZBD-UHFFFAOYSA-N
SMILES FC(F)(F)c1ccnc(Cl)n1
CAS DataBase Reference 33034-67-2(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,F
Risk Statements  10-36/37/38
Safety Statements  16-26-36-37/39
RIDADR  UN 1993 3/PG 3
WGK Germany  3
Hazard Note  Irritant
HazardClass  3.2
PackingGroup  III
HS Code  29335990
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

2-Chloro-4-(trifluoromethyl)pyrimidine price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 407070 2-Chloro-4-(trifluoromethyl)pyrimidine 99% 33034-67-2 1g $28.5 2026-04-30 Buy
Sigma-Aldrich 407070 2-Chloro-4-(trifluoromethyl)pyrimidine 99% 33034-67-2 5g $42.9 2023-06-20 Buy
TCI Chemical C2467 2-Chloro-4-(trifluoromethyl)pyrimidine >98.0%(GC) 33034-67-2 1g $46 2026-04-30 Buy
TCI Chemical C2467 2-Chloro-4-(trifluoromethyl)pyrimidine >98.0%(GC) 33034-67-2 5g $155 2026-04-30 Buy
Matrix Scientific 008885 2-Chloro-4-(trifluoromethyl)pyrimidine 33034-67-2 25.00g $28 2026-05-18 Buy
Product number Packaging Price Buy
407070 1g $28.5 Buy
407070 5g $42.9 Buy
C2467 1g $46 Buy
C2467 5g $155 Buy
008885 25.00g $28 Buy

2-Chloro-4-(trifluoromethyl)pyrimidine Chemical Properties,Uses,Production

Chemical Properties

Colourless Liquid

Uses

2-Chloro-4-(trifluoromethyl)pyrimidine may be used to investigate the effect of chemical substitutions on the interfacial interactions of pyrimidines with the phospholipid-mimic immobilized-artificial-membrane (IAM) chromatographic stationary phase. Monocyclic pyrimidine nucleic acid bases (nucleobases) were reported to behave differently from their bicyclic purine analogs.

General Description

2-Chloro-4-(trifluoromethyl)pyrimidine is a pyrimidine derivative. Its density and refractive index have been determined.

Synthesis

First, ethyl trifluoroacetoacetate and urea are refluxed for 4 hours in an ethanol-hydrochloric acid system, and the mixture is cooled to precipitate 2-hydroxy-4-(trifluoromethyl)pyrimidine (intermediate, with a purity of about 95%). Then the intermediate is mixed with phosphorus oxychloride (POCl₃) with 1 drop of DMF as a catalyst, and the reaction is carried out at 80-120 °C for 2-6 hours. After recovering the excess POCl₃, the reaction solution is quenched by pouring into ice water, followed by extraction with ethyl acetate, drying and vacuum distillation (collecting the fraction at 60 °C/10 mmHg) to obtain 2-chloro-4-(trifluoromethyl)pyrimidine, with an overall yield of about 70%.

2-Chloro-4-(trifluoromethyl)pyrimidine synthesis

104048-92-2
33034-67-2
Synthesis of 2-Chloro-4-(trifluoromethyl)pyrimidine from 2-Hydroxy-4-(trifluoromethyl)pyrimidine

2-Chloro-4-(trifluoromethyl)pyrimidine Preparation Products And Raw materials

Raw materials

n-Butyl vinyl ether Ethyl vinyl ether Ethanol Sodium Trifluoroacetic acid
Phosphorus oxitrichloride Urea Trifluoroacetic anhydride Hydrochloric acid Pyridine
4-Dimethylaminopyridine 2-Hydroxy-4-(trifluoromethyl)pyrimidine

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Preparation Products

(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

2-Chloro-4-(trifluoromethyl)pyrimidine Suppliers

Global( 274)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Liyang Kunlun Biological Technology Co., Ltd. 		+86-13813530041 z13813530041@126.com China 337 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Supplier Advantage
Jiangsu Liyang Kunlun Biological Technology Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58

View Lastest Price from 2-Chloro-4-(trifluoromethyl)pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-(trifluoromethyl)pyrimidine pictures 2025-11-18 2-Chloro-4-(trifluoromethyl)pyrimidine
33034-67-2
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-chloro-4-(trifluoromethyl)pyrimidine pictures 2025-04-02 2-chloro-4-(trifluoromethyl)pyrimidine
33034-67-2
 US $0.00 / kg 500kg 0.99 20 tons Jiangsu Liyang Kunlun Biological Technology Co., Ltd.
2-Chloro-4-(trifluoromethyl)pyrimidine pictures 2021-08-12 2-Chloro-4-(trifluoromethyl)pyrimidine
33034-67-2
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

2-Chloro-4-(trifluoromethyl)pyrimidine Spectrum

2-Chloro-4-(trifluoromethyl)pyrimidine(33034-67-2)1HNMR2-Chloro-4-(trifluoromethyl)pyrimidine(33034-67-2)IR2-Chloro-4-(trifluoromethyl)pyrimidine(33034-67-2)FT-IR

33034-67-2(2-Chloro-4-(trifluoromethyl)pyrimidine)Related Search:

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BUTTPARK 27\08-69 4-(TRIFLUOROMETHYL)-2-CHLOROPYRIMIDINE 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE 2-Chloro-4-(trifluoromethyl)pyrimidine 99% 2-Chloro-4-(trifluoromethyl)pyrimidine99% IFLAB-BB F13 Pyrimidine, 2-chloro-4-(trifluoromethyl)- 2-Chloro-4-(trifluoromethyl)pyrimidine > 2-Chloro-4-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH 33034-67-2 C5H2CIF3N2 C5H2ClF3N2 C5H2ClF2N2 HETERO CHLORIDE Pyrimidines Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Bases & Related Reagents Nucleotides Pyrazines, Pyrimidines & Pyridazines Boronic Acid Heterocyclic Compounds Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Nucleotides and Nucleosides Pyrimidines Variety of halogenated heterocyclic series Fluorine series Halides Pyrazines, Pyrimidines & Pyridazines Pyrimidine Pyrimidine series