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ChemicalBook >> CAS DataBase List >>1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Structure
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate structure
CAS No.
374794-96-4
Chemical Name:
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
Synonyms
8-Boc-2-oxa-8-azaspiro[4.5]decane;2-Oxa-8-azaspiro[4.5]decane-8-carboxylicacid;tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate;1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate;2-Oxa-8-azaspiro[4.5]decane-8-CARBOXYLIC ACID TERT-BUTYL ESTER;2-oxy-8-azaspiro[4.5]decylalkane-8-carboxylic acidtertbutyl ester;2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester
CBNumber:
CB41512434
Molecular Formula:
C13H23NO3
Molecular Weight:
241.33
MDL Number:
MFCD11042295
MOL File:
374794-96-4.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:49
Product description Number Pack Size Price
tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% P000389233 100mg $41
tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% P000389233 250mg $61
Tert-butyl2-oxa-8-azaspiro[4.5]decane-8-carboxylate 9240CZ 250mg $141
tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% P000389233 1g $152
1,1-DIMETHYLETHYL-2-OXA-8-AZASPIRO[4.5]DECANE-8-CARBOXYLATE 95.00% CHM0152468 5MG $499.13
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1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Properties

Boiling point 333.5±35.0 °C(Predicted)
Density 1.08±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka -0.77±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Ark Pharm P000389233 tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 100mg $41 2021-12-16 Buy
Ark Pharm P000389233 tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 250mg $61 2021-12-16 Buy
AK Scientific 9240CZ Tert-butyl2-oxa-8-azaspiro[4.5]decane-8-carboxylate 374794-96-4 250mg $141 2021-12-16 Buy
Ark Pharm P000389233 tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 1g $152 2021-12-16 Buy
American Custom Chemicals Corporation CHM0152468 1,1-DIMETHYLETHYL-2-OXA-8-AZASPIRO[4.5]DECANE-8-CARBOXYLATE 95.00% 374794-96-4 5MG $499.13 2021-12-16 Buy
Product number Packaging Price Buy
P000389233 100mg $41 Buy
P000389233 250mg $61 Buy
9240CZ 250mg $141 Buy
P000389233 1g $152 Buy
CHM0152468 5MG $499.13 Buy

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical Properties,Uses,Production

Synthesis

1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester

236406-38-5

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

374794-96-4

General procedure for the synthesis of tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate from 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester: A solution of diethyl azodicarboxylate (183 μL, 1.16 mmol) of tetrahydrofuran (0.5 mL) was slowly added dropwise to a stirring 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylic acid tert-butyl ester (250 mg, 0.96 mmol) at 0 °C. tert-butyl 4-(hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (250 mg, 0.96 mmol) and triphenylphosphine (303 mg, 1.16 mmol) solution in tetrahydrofuran (10 mL) under stirring. The reaction mixture was stirred at 0 °C for 90 min, followed by stirring at room temperature overnight. Afterwards, the mixture was cooled to 0-20 °C and additional triphenylphosphine (126 mg, 0.48 mmol) and diethyl azodicarboxylate (76 μL, 0.48 mmol) were added. The mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was purified by fast column chromatography on silica gel using isohexane/ethyl acetate (80:20) as eluent to afford tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate as a colorless oil (150 mg, 65% yield). Mass spectrum (electrospray positive ion mode) m/z: 186 ([M+1-C4H8]+).

References

[1] Patent: US2003/225059, 2003, A1. Location in patent: Page 27
[2] Patent: US2003/236250, 2003, A1. Location in patent: Page 30
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 13, p. 1759 - 1762

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials

Raw materials

1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester Triphenylphosphine Tetrahydrofuran Diethyl azodicarboxylate

Preparation Products

2-Oxa-8-azaspiro[4.5]decane

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Suppliers

Global( 40)Suppliers
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Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14343 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39002 58
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18207 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10186 62
Tianjin Yao Technology Development Co., Ltd. 022-18902014291 18902014291 byswxsb01@163.com China 99 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Win-Win chemical CO., Limited 		58
Nextpeptide Inc 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Tianjin Yao Technology Development Co., Ltd. 58

View Lastest Price from 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate pictures 2019-12-27 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
374794-96-4
 US $6.60 / KG 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Spectrum

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate(374794-96-4)1HNMR

374794-96-4(1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate)Related Search:

2-Oxa-8-azaspiro[4.5]decane 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 2-Oxa-8-azaspiro[4.5]decane-8-carboxylicacid 2-Oxa-8-azaspiro[4.5]decane-8-CARBOXYLIC ACID TERT-BUTYL ESTER 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester 8-Boc-2-oxa-8-azaspiro[4.5]decane 2-oxy-8-azaspiro[4.5]decylalkane-8-carboxylic acidtertbutyl ester 374794-96-4 API intermediates