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ChemicalBook >> CAS DataBase List >>1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Structure
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate structure
CAS No.
374794-96-4
Chemical Name:
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
Synonyms
8-Boc-2-oxa-8-azaspiro[4.5]decane;2-Oxa-8-azaspiro[4.5]decane-8-carboxylicacid;tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate;1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate;2-Oxa-8-azaspiro[4.5]decane-8-CARBOXYLIC ACID TERT-BUTYL ESTER;2-oxy-8-azaspiro[4.5]decylalkane-8-carboxylic acidtertbutyl ester;2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester
CBNumber:
CB41512434
Molecular Formula:
C13H23NO3
Molecular Weight:
241.33
MDL Number:
MFCD11042295
MOL File:
374794-96-4.mol
MSDS File:
SDS
Last updated:2026-05-28 02:09:48
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1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Properties

Boiling point 333.5±35.0 °C(Predicted)
Density 1.08±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka -0.77±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix B57253 tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 100mg $64 2026-05-06 Buy
Synthonix B57253 tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 250mg $80 2026-05-06 Buy
Synthonix B57253 tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 1g $220 2026-05-06 Buy
aablocks AA00C75C tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 250mg $55 2026-05-28 Buy
aablocks AA00C75C tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 95% 374794-96-4 500mg $90 2026-05-28 Buy
Product number Packaging Price Buy
B57253 100mg $64 Buy
B57253 250mg $80 Buy
B57253 1g $220 Buy
AA00C75C 250mg $55 Buy
AA00C75C 500mg $90 Buy

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical Properties,Uses,Production

Synthesis

1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester

236406-38-5

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

374794-96-4

General procedure for the synthesis of tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate from 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester: A solution of diethyl azodicarboxylate (183 μL, 1.16 mmol) of tetrahydrofuran (0.5 mL) was slowly added dropwise to a stirring 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylic acid tert-butyl ester (250 mg, 0.96 mmol) at 0 °C. tert-butyl 4-(hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (250 mg, 0.96 mmol) and triphenylphosphine (303 mg, 1.16 mmol) solution in tetrahydrofuran (10 mL) under stirring. The reaction mixture was stirred at 0 °C for 90 min, followed by stirring at room temperature overnight. Afterwards, the mixture was cooled to 0-20 °C and additional triphenylphosphine (126 mg, 0.48 mmol) and diethyl azodicarboxylate (76 μL, 0.48 mmol) were added. The mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was purified by fast column chromatography on silica gel using isohexane/ethyl acetate (80:20) as eluent to afford tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate as a colorless oil (150 mg, 65% yield). Mass spectrum (electrospray positive ion mode) m/z: 186 ([M+1-C4H8]+).

References

[1] Patent: US2003/225059, 2003, A1. Location in patent: Page 27
[2] Patent: US2003/236250, 2003, A1. Location in patent: Page 30
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 13, p. 1759 - 1762

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials

Raw materials

1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester Triphenylphosphine Tetrahydrofuran Diethyl azodicarboxylate

Preparation Products

2-Oxa-8-azaspiro[4.5]decane

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Suppliers

Global( 39)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Tianjin Yao Technology Development Co., Ltd. 022-18902014291 18902014291 byswxsb01@163.com China 98 58
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
Jinan SanZhi Pharmaceutical Technology Co., Ltd. 15053191807 sales_sanzhi@163.com China 286 55
parabiochem 025-83453382-8005 sale@parabiochem.com China 9577 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai Kaimo Pharmaceutical Co., Ltd. 021-50521023 18019779209 sales@kaimopharm.com China 227 58
Shanghai Huaxing Biological Technology Co., Ltd. 18621295758; 18621295758 1449085402@qq.com China 1973 55
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Supplier Advantage
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Tianjin Yao Technology Development Co., Ltd. 58
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Jinan SanZhi Pharmaceutical Technology Co., Ltd. 55
parabiochem 55
Shanghai Chaolan Chemical Technology Center 58
Shanghai Kaimo Pharmaceutical Co., Ltd. 58
Shanghai Huaxing Biological Technology Co., Ltd. 55
Capot Chemical Co.,Ltd. 60

View Lastest Price from 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate pictures 2019-12-27 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
374794-96-4
 $6.60 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Spectrum

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate(374794-96-4)1HNMR

374794-96-4(1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate)Related Search:

2-Oxa-8-azaspiro[4.5]decane 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate 2-Oxa-8-azaspiro[4.5]decane-8-carboxylicacid 2-Oxa-8-azaspiro[4.5]decane-8-CARBOXYLIC ACID TERT-BUTYL ESTER 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester 8-Boc-2-oxa-8-azaspiro[4.5]decane 2-oxy-8-azaspiro[4.5]decylalkane-8-carboxylic acidtertbutyl ester 374794-96-4 API intermediates