Diethyl azodicarboxylate
- CAS No.
- 1972-28-7
- Chemical Name:
- Diethyl azodicarboxylate
- Synonyms
- DEAD;DAD;(E)-di-tert-butyl diazene-1,2-dicarboxylate;Diethyl diazene-1,2-dicarboxylate;AZODICARBOXYLIC ACID DIETHYL ESTER;Ethyl (NE)-N-ethoxycarbonyliminocarbamate;Ethyl azodicarboxylate;(E)-diethyl diazene-1,2-dicarboxylate;DiethylAzidoCarboxylate;Diethoxycarbonyldiazene
- CBNumber:
- CB6432076
- Molecular Formula:
- C6H10N2O4
- Molecular Weight:
- 174.15
- MDL Number:
- MFCD00009103
- MOL File:
- 1972-28-7.mol
- MSDS File:
- SDS
| Melting point | 6°C |
|---|---|
| Boiling point | 106°C (13 mmHg) |
| Density | 1.106 |
| refractive index |
n |
| Flash point | 85°C |
| storage temp. | 2-8°C |
| solubility | Miscible with dichloromethane, diethyl ether and toluene. |
| form | liquid |
| color | Clear, orange |
| Sensitive | Air Sensitive |
| BRN | 908662 |
| Stability | Stable, but may explode if heated under confinement. May be shock sensitive. Decomposes vigorously if heated above 100 C. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents. Light sensitive. |
| InChI | InChI=1S/C6H10N2O4/c1-3-11-5(9)7-8-6(10)12-4-2/h3-4H2,1-2H3 |
| InChIKey | FAMRKDQNMBBFBR-FPLPWBNLSA-N |
| SMILES | N(C(OCC)=O)=NC(OCC)=O |
| CAS DataBase Reference | 1972-28-7(CAS DataBase Reference) |
| FDA UNII | D31B4839S8 |
| NIST Chemistry Reference | Diethyl azo diformate(1972-28-7) |
| UNSPSC Code | 12352108 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H242-H304-H315-H319-H335-H336-H361d-H373-H412 | |||||||||
| Precautionary statements | P210-P301+P310-P331-P370+P378-P403+P233-P403+P235 | |||||||||
| target organs | Central nervous system, Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F,Xn,Xi | |||||||||
| Risk Statements | 5-11-20-36/37/38-48/20-63-65-67-48/20/22-40-20/22-20/21/22-10 | |||||||||
| Safety Statements | 26-36/37-62-47-36-35 | |||||||||
| RIDADR | UN 3233 4.1 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 9 | |||||||||
| Hazard Note | Toxic/Irritant/Flammable | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29270000 | |||||||||
| Storage Class | 5.2 - Organic peroxides and self-reacting hazardous materials | |||||||||
| Hazard Classifications | Aquatic Chronic 3 Asp. Tox. 1 Eye Irrit. 2 Flam. Liq. 3 Repr. 2 Self-react. C Skin Irrit. 2 STOT RE 2 STOT SE 3 |
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| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Diethyl azodicarboxylate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 563110 | Diethyl azodicarboxylate solution 40 wt. % in toluene | 1972-28-7 | 25g | $77.4 | 2025-07-31 | Buy |
| Sigma-Aldrich | 563110 | Diethyl azodicarboxylate solution 40 wt. % in toluene | 1972-28-7 | 100g | $254 | 2025-07-31 | Buy |
| AK Scientific | L997 | Diethyl azodicarboxylate solution 40wt.%intoluene | 1972-28-7 | 5g | $29 | 2026-06-04 | Buy |
| AK Scientific | L997 | Diethyl azodicarboxylate solution 40wt.%intoluene | 1972-28-7 | 25g | $77 | 2026-06-04 | Buy |
| AK Scientific | L997 | Diethyl azodicarboxylate solution 40wt.%intoluene | 1972-28-7 | 100g | $254 | 2026-06-04 | Buy |
Diethyl azodicarboxylate Chemical Properties, Uses, Production
Chemical Properties
Clear orange to orange-red liquid
Uses
A fluorescent CDK inhibitor for treatment of cancer
Uses
Reactant for preparation of:
- Immunostimulants α-Galactosylceramides
- Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
- Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
- Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
- Aza-β-lactams via NHC-catalyzed [2 + 2] cycloaddition with ketenes
Reagent for:
- Annulation of N-protected imines
- α-thiocyanation of enolizable ketones with ammonium thiocyanate
- Diels-Alder reactions
General Description
DOT Special Approval Submission is Under Review. Availability is Estimated as March 2012.
Synthesis
Diethyl azodicarboxylate (DEAD) can be obtained from 1,2-bis(ethoxycarbonyl)hydrazine by oxidation with nitric acid.
Purification Methods
Dissolve DEAD in toluene, wash it with 10% NaHCO3 till neutral (may require several washes if too much hydrolysis had occurred: check IR for OH bands), then wash with H2O (2x), dry over Na2SO4, filter, evaporate the toluene and distil it through a short Vigreux column (p 11) at as high a vacuum as possible. The main portion boils at 107-111o/15mm. Since it is likely to explode, use an oil bath for heating the still and all operations should be carried -out behind an adequate shield. [Rabjohn Org Synth Coll Vol III 375 1955, see Kauer Org Synth Coll Vol IV 412 1963]. [Beilstein 3 III 233.] It is commercially available as a 40% solution in toluene. This reagent is useful in the Mitsunobu reaction [Mitsunobu Synthesis 1 1981, Gennari et al. J Am Chem Soc 108 6394 1986, Evans et al. J Am Chem Soc 108 6394 1986, Hughes Org React 42 335 1992, Dodge et al. Org Synth 73 110 1996, Hughes Org Prep Proc Int 28 127 1996, Ferguson & Marcelle J Am Chem Soc 128 4576 2006; see also di-tert-butyl azodicarboxylate above and DIAD below]. § A polystyrene supported DEAD version is commercially available with a loading of ~1.2mmol/g.
Diethyl azodicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Hanxuan Biotechnology Co., Ltd | 18602598900，18605190599 18602598900 | 1669093670@qq.com | China | 95 | 58 |
| Nanjing Winsome Chemical Limited | 025-84651981 18652010011 | sales@nastchem.com | China | 81 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| NANJING SHUNXIANG PHARMACEUTICAL TECHNOLOGY CO.,LTD. | 025-86819863 13913839793 | sales@jinchemical.com | China | 26 | 58 |
| Shanghai Yanze Chemical Co., Ltd. | 15345144255 19975051755 | 260924549@qq.com | China | 2979 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
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View Latest Price from Diethyl azodicarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-25 | Diethyl azodicarboxylate
1972-28-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-24 | Diethyl azodicarboxylate
1972-28-7
|
$75.00-100.00 | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-09-22 | Diethyl azodicarboxylate
1972-28-7
|
1kg | 98% | 1 | Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd. |
-
- Diethyl azodicarboxylate
1972-28-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Diethyl azodicarboxylate
1972-28-7
- $75.00-100.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Diethyl azodicarboxylate
1972-28-7
- $0.00
- 98%
- Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
