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7-Fluoro-2H-1,4-benzoxazin-3(4H)-one

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one structure

CAS No.: 103361-99-5

Chemical Name:: 7-Fluoro-2H-1,4-benzoxazin-3(4H)-one

Synonyms: 7-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;7-Fluoro-4H-benzo[1,4]oxazin-3-one;7-Fluoro-2H-1,4-benzoxazin-3(4H)-one;7-Fluoro-2H-benzo[b][1,4]oxazin-3(4H);2H-1,4-Benzoxazin-3(4H)-one, 7-fluoro-;7-FLUORO-2,4-DIHYDRO-1,4-BENZOXAZIN-3-ONE;7-fluoro-3,4-dihydro-2H-1,4-benzoxazin-3-one;7-fluoro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine;3-Oxo-7-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine;3,4-Dihydro-7-fluoro-3-oxo-2H-1,4-benzoxazine, 7-Fluoro-4H-benzo[b][1,4]oxazin-3-one

CBNumber:: CB41517828

Molecular Formula:: C8H6FNO2

Molecular Weight:: 167.14

MDL Number:: MFCD07774200

MOL File:: 103361-99-5.mol

Last updated:2026-09-12 18:52:25

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7-Fluoro-2H-1,4-benzoxazin-3(4H)-one Properties

Melting point	203-205°
Boiling point	327.9±42.0 °C(Predicted)
Density	1.347
storage temp.	Sealed in dry,Room Temperature
pka	11.56±0.20(Predicted)
Appearance	Light brown to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HazardClass	IRRITANT
HS Code	2934999090

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	294958	7-Fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one	103361-99-5	250.00mg	$30	2026-05-19	Buy
Matrix Scientific	294958	7-Fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one	103361-99-5	1.00g	$82	2026-05-19	Buy
Matrix Scientific	294958	7-Fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one	103361-99-5	5.00g	$248	2026-05-19	Buy
aablocks	AA007XLW	7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE 98%	103361-99-5	250mg	$21	2026-05-28	Buy
aablocks	AA007XLW	7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE 98%	103361-99-5	1g	$56	2026-05-28	Buy

Product number	Packaging	Price	Buy
294958	250.00mg	$30	Buy
294958	1.00g	$82	Buy
294958	5.00g	$248	Buy
AA007XLW	250mg	$21	Buy
AA007XLW	1g	$56	Buy

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one Chemical Properties,Uses,Production

Synthesis

Acetic acid, 2-(5-fluoro-2-nitrophenoxy)-, ethyl ester

103362-07-8

103361-99-5

Ethyl 2-nitro-5-fluorophenoxyacetate (50 mmol) was added to 50 mL of glacial acetic acid. It was heated to reflux under stirring conditions and iron powder (100 mmol) was added in three batches. After addition, the reaction was continued to reflux for 3 hours. Upon completion of the reaction, the filtrate was filtered through a diatomaceous earth pad while hot to remove the iron powder. The filtrate was cooled to room temperature and then slowly poured into 200 mL of water with vigorous stirring for 30 minutes. The precipitated solid was collected by filtration, washed with deionized water and dried under vacuum to give 7.18 g of white solid product 7-fluoro-2H-1,4-benzoxazin-3(4H)-one in 86% yield.

References

[1] Patent: CN108727367, 2018, A. Location in patent: Paragraph 0138; 0142; 0143
[2] Patent: WO2014/122674, 2014, A1. Location in patent: Paragraph 00065
[3] Patent: WO2011/151361, 2011, A1. Location in patent: Page/Page column 40-41
[4] Patent: WO2013/153539, 2013, A1. Location in patent: Page/Page column 47
[5] Journal of Agricultural and Food Chemistry, 2017, vol. 65, # 26, p. 5278 - 5286

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one Preparation Products And Raw materials

Raw materials

2-Amino-5-fluorophenol Acetamide, 2-chloro-N-(4-fluoro-2-hydroxyphenyl)- Acetonitrile, 2-(5-fluoro-2-nitrophenoxy)- Acetic acid, 2-(5-fluoro-2-nitrophenoxy)-, ethyl ester Chloroacetyl chloride

Preparation Products

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one Suppliers

Global( 73)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Atop-Pharma (Shanghai) Technology Co., Ltd.	+86 (21) 5196-9732		China	996	57
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Shanghai Raise Chemical Technology Co.,Ltd	15026594951	rs@raise-chem.com	China	4905	55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	+86-28-85122536 85324413	market@astatech.cn	China	8016	55
Shanghai JONLN Reagent Co., Ltd.	400-0066400 13621662912	422131432@qq.com	China	9970	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Hotechem Shanghai Co., Ltd.,	021-34621078 13120882795	465106944@qq.com	China	859	56
Zhengzhou Guancheng Laboratory equipment Sales	0371-88888888 qq272369594;2159423853qq	2723695949@qq.com	China	4991	50

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Wuhan Chemwish Technology Co., Ltd	56
Atop-Pharma (Shanghai) Technology Co., Ltd.	57
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai Raise Chemical Technology Co.,Ltd	55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	55
Shanghai JONLN Reagent Co., Ltd.	55
Bide Pharmatech Ltd.	60
Hotechem Shanghai Co., Ltd.,	56
Zhengzhou Guancheng Laboratory equipment Sales	50

7-Fluoro-2H-1,4-benzoxazin-3(4H)-one Spectrum

7-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(103361-99-5)¹HNMR

103361-99-5(7-Fluoro-2H-1,4-benzoxazin-3(4H)-one)Related Search:

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6,7-Difluoro-4H-benzo[1,4]oxazin-3-one

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7-FLUORO-2,4-DIHYDRO-1,4-BENZOXAZIN-3-ONE 3-Oxo-7-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine 7-Fluoro-4H-benzo[1,4]oxazin-3-one 7-fluoro-3,4-dihydro-2H-1,4-benzoxazin-3-one 3,4-Dihydro-7-fluoro-3-oxo-2H-1,4-benzoxazine, 7-Fluoro-4H-benzo[b][1,4]oxazin-3-one 7-Fluoro-2H-benzo[b][1,4]oxazin-3(4H) 7-fluoro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine 2H-1,4-Benzoxazin-3(4H)-one, 7-fluoro- 7-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE 7-Fluoro-2H-1,4-benzoxazin-3(4H)-one 103361-99-5 Heterocycles