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S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid structure

CAS No.: 21416-43-3

Chemical Name:: S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

Synonyms: willardiine;C03584;Willardine;L-WILLARDIINE;(-)-WILLARDIINE;S(-)-WILLARDIINE;3-(Uracil-1-yl)-L-alanine;S(-)-WILLARDIINE AMPA/KAINATE AGONIST;3-[(2,4-Dioxo-1,2,3,4-tetrahydropyrimidine)-1-yl]-L-alanine;S(-)-α-Amino--3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

CBNumber:: CB4154747

Molecular Formula:: C7H9N3O4

Molecular Weight:: 199.16

MDL Number:: MFCD00153879

MOL File:: 21416-43-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:28

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S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Properties

Melting point	204-205 °C
storage temp.	2-8°C(protect from light)
solubility	0.1 M NaOH: 7.2 mg/mL
Density	1.501±0.06 g/cm3(Predicted)
pka	2.12±0.10(Predicted)
form	solid
color	white
FDA UNII	X2R4I0X4W9

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	WAA41643	(S)-Willardiine	21416-43-3	50mg	$2154.5	2026-06-05	Buy
Biosynth	WAA41643	(S)-Willardiine	21416-43-3	0.5g	$2454.4	2026-06-05	Buy
ChemScene	CS-3618	(S)-Willardiine 98.93%	21416-43-3	5mg	$65	2026-06-04	Buy
ChemScene	CS-3618	(S)-Willardiine 98.93%	21416-43-3	10mg	$102	2026-06-04	Buy
ChemScene	CS-3618	(S)-Willardiine 98.93%	21416-43-3	25mg	$238	2026-06-04	Buy

Product number	Packaging	Price	Buy
WAA41643	50mg	$2154.5	Buy
WAA41643	0.5g	$2454.4	Buy
CS-3618	5mg	$65	Buy
CS-3618	10mg	$102	Buy
CS-3618	25mg	$238	Buy

S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Chemical Properties,Uses,Production

Description

This simple base occurs in germinatine pea seeds or seedlings. The structure given above has been determined from chemical and s'pectroscopic analysis.

Uses

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. IC50 value: 44.8 uM(EC50) [1] Target: AMPA/kainate receptor agonist in vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2]. in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3].

Definition

ChEBI: 3-(uracil-1-yl)-L-alanine is the 3-(uracil-1-yl) derivative of L-alanine. It is a non-proteinogenic L-alpha-amino acid and a L-alanine derivative. It is functionally related to a uracil. It is a tautomer of a 3-(uracil-1-yl)-L-alanine zwitterion.

IC 50

Kainate Receptor

References

Ashworth, Brown, Roberts., Biochern J., 129,897 (1972)

S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Suppliers

Global( 49)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
ShangHai KenEn Chemical Technology Co., Ltd.	13120367189;18621755571	mychess007@163.com	China	1994	55
BOC Sciences	16314854226	info@bocsci.com	United States	9909	65
Guangzhou QiYun Biotechnology Co., Ltd.	020-61288194 61288195	505721671@qq.com	China	3853	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Musechem	+1-800-259-7612	info@musechem.com	United States	4648	60
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9718	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58

Supplier	Advantage
Ascent Scientific	60
Haoyuan Chemexpress Co., Ltd.	61
ShangHai KenEn Chemical Technology Co., Ltd.	55
BOC Sciences	65
Guangzhou QiYun Biotechnology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Amadis Chemical Company Limited	58
Musechem	60
Fan De(Beijing) Biotechnology Co., Ltd.	58
BOC Sciences	58

View Lastest Price from S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-10	(S)-Willardiine 21416-43-3	$50.00-344.00		99.85%	10g	TargetMol Chemicals Inc.
	2026-04-20	(S)-Willardiine 21416-43-3	$50.00-344.00		99.85%	10g	TargetMol Chemicals Inc.

(S)-Willardiine
21416-43-3
$50.00-344.00
99.85%
TargetMol Chemicals Inc.

(S)-Willardiine
21416-43-3
$50.00-344.00
99.85%
TargetMol Chemicals Inc.

S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid Spectrum

S(-)-ALPHA-AMINO-3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID(21416-43-3)¹HNMR

21416-43-3(S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid)Related Search:

3-Chloro-L-alanine hydrochloride EC 2.6.1.2 Boscalid Sodium diacetate D-Alanine

(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione (S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid (αS)-alpha-amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid (αS)-alpha-amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid (S)-(-)-5-Iodowillardiine

(S)-(-)-5-Fluorowillardiine S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid (S)-5-Nitrowillardiine

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L-WILLARDIINE S(-)-WILLARDIINE S(-)-WILLARDIINE AMPA/KAINATE AGONIST S(-)-α-Amino--3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid (2S)-2-Amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-yl)propionic acid (S)-2-Amino-3-[2,4-dioxo-3,4-dihydropyrimidine-1(2H)-yl]propanoic acid 3-[(2,4-Dioxo-1,2,3,4-tetrahydropyrimidine)-1-yl]-L-alanine Willardine 3-(Uracil-1-yl)-L-alanine C03584 1(2H)-Pyrimidinepropanoic acid, α-amino-3,4-dihydro-2,4-dioxo-, (αS)- (-)-WILLARDIINE willardiine S(-)-alpha-amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid 21416-43-3 C7H9N3O4 Ligand-Gated Ion Channels Ionotropic Glutamate Receptor Modulators Ion Channels BioChemical Cell Signaling and Neuroscience Cell Biology Glutamate