(S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid
- CAS No.
- 389888-02-2
- Chemical Name:
- (S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid
- Synonyms
- (S)-CPW 399;(2S)-2-amino-3-(2,4-dioxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl)propanoic acid;(S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoicacid;(S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid;1H-Cyclopentapyrimidine-1-propanoic acid, α-amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-, (αS)-
- CBNumber:
- CB4388111
- Molecular Formula:
- C10H13N3O4
- Molecular Weight:
- 239.23
- MDL Number:
- MFCD06798372
- MOL File:
- 389888-02-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >163°C (dec.) |
|---|---|
| storage temp. | Desiccate at -20°C |
| solubility | Aqueous Acid (Slightly, Heated, Sonicated), DMSO (Slightly) |
| form | Solid |
| color | Pale Brown to Brown |
| Water Solubility | Soluble to 50 mM in water |
(S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C781478-50MG | (S)-CPW 399 | 389888-02-2 | 50mg | $1038 | 2026-06-03 | Buy |
| TRC | TRC-C781478-10MG | (S)-CPW 399 | 389888-02-2 | 10mg | $223 | 2026-06-03 | Buy |
| TRC | TRC-C781478-100MG | (S)-CPW 399 | 389888-02-2 | 100mg | $1785 | 2026-06-03 | Buy |
| ApexBio Technology | B6781 | (S)-CPW 399 | 389888-02-2 | 10mg | $338 | 2026-05-06 | Buy |
| ApexBio Technology | B6781 | (S)-CPW 399 | 389888-02-2 | 50mg | $1430 | 2026-05-06 | Buy |
(S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid Chemical Properties, Uses, Production
Uses
(S)-CPW 399 is a subtype-selective weakly desensitising AMPA agonist.
Biological Activity
Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (K i values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Exhibits potent agonist activity at GluR1 and GluR2 subunit-containing AMPA receptors (EC 50 values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro .
References
[1]. campiani g, morelli e, nacci v, et al. characterization of the 1h-cyclopentapyrimidine-2,4(1h,3h)-dione derivative (s)-cpw399 as a novel, potent, and subtype-selective ampa receptor full agonist with partial desensitization properties. j med chem, 2001, 44(26): 4501-4504.
[2]. sinclair c, reavy h, grieve a, et al. inherent desensitisation-preventing properties of a novel, subtype-selective ampa receptor agonist, (s)-cpw 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. neurochem int, 2003, 42(6): 499-510.
[3]. salonen v, kallinen s, lopez-picon fr, et al. ampa/kainate receptor-mediated up-regulation of gabaa receptor delta subunit mrna expression in cultured rat cerebellar granule cells is dependent on nmda receptor activation. brain res, 2006, 1087(1): 33-40.
[4]. butini s, pickering ds, morelli e, et al. 1h-cyclopentapyrimidine-2,4(1h,3h)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and selective iglur5 modulators. j med chem, 2008, 51(20): 6614-6618.
(S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-alpha-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19904 | 58 |
| Shanghai Anhua Biotechnology Co., Ltd. | 021-61263375 18168859245 | China | 5955 | 58 | |
| Wuxi maimo topp biotechnology co., LTD | 15861600115 | lisa-li@mimotopes.cn | China | 5795 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11706 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 17717235263 | offer.de@lgcgroup.com | China | 38135 | 58 |
