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4-Borono-L-phenylalanine

4-Borono-L-phenylalanine structure

CAS No.: 76410-58-7

Chemical Name:: 4-Borono-L-phenylalanine

Synonyms: 4-boronophenylalanine;L-p-Boronophenylalanine;4-dihydroxyboryl-l-phenylalanine;4-L-BPA;EOS-61315;L-PHE[B(OH)2];H-S-PHE(4-B(OH)2)-OH;Lisinopril Impurity 26;4-BORONO-L-PHENYLALANIN;4-Borono-L-phenylalanine

CBNumber:: CB4155764

Molecular Formula:: C9H12BNO4

Molecular Weight:: 209.01

MDL Number:: MFCD01075172

MOL File:: 76410-58-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:28

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4-Borono-L-phenylalanine Properties

Melting point	285-293℃ (dec.)
Boiling point	449.3±55.0 °C(Predicted)
Density	1.34±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Inert atmosphere,2-8°C
solubility	Aqueous Acid (Slightly)
pka	2.20±0.10(Predicted)
form	Powder
color	White to off-white
BRN	4458616
InChI	InChI=1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1
InChIKey	NFIVJOSXJDORSP-QMMMGPOBSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(B(O)O)C=C1)N
CAS DataBase Reference	76410-58-7(CAS DataBase Reference)
FDA UNII	JSM63LV5MD
UNSPSC Code	12352209
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
F	1-10
HazardClass	IRRITANT
HS Code	29310099
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

4-Borono-L-phenylalanine price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	17755	4-Borono-L-phenylalanine ≥95.0% (HPLC)	76410-58-7	250mg	$342	2026-04-30	Buy
TCI Chemical	B6405	4-Borono-L-phenylalanine (contains varying amounts of Anhydride)	76410-58-7	250MG	$98	2026-04-30	Buy
TRC	TRC-B675600-500MG	4-Borono-L-phenylalanine	76410-58-7	500mg	$581	2026-06-03	Buy
TRC	TRC-B675600-250MG	4-Borono-L-phenylalanine	76410-58-7	250mg	$339	2026-06-03	Buy
TRC	TRC-B675600-100MG	4-Borono-L-phenylalanine	76410-58-7	100mg	$188	2026-06-03	Buy

Product number	Packaging	Price	Buy
17755	250mg	$342	Buy
B6405	250MG	$98	Buy
TRC-B675600-500MG	500mg	$581	Buy
TRC-B675600-250MG	250mg	$339	Buy
TRC-B675600-100MG	100mg	$188	Buy

4-Borono-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

4-Borono-L-phenylalanine is an unnatural derivative of L-Phenylalanine (P319415). a nonpolar, essential amino acid that naturally occurs in the human body and is also used to treat patients with depression. 4-Borono-L-phenylalanine is also being used as a mediator in sequential boron neutron capture therapy, a new method of treating oral cancer.

Synthesis

(S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

119771-23-2

76410-58-7

The general procedure for the synthesis of (S)-2-amino-3-(4-boronic acid phenyl)propionic acid from (S)-3-(4-boronic acid phenyl)-2-((tert-butoxycarbonyl)amino)propionic acid was as follows: (S)-N-Boc-4-borophenylalanine (5.63 g, 98.5% purity, 17.9 mmol) was suspended in a solvent mixture of acetone (34 mL) and water (3.8 mL). Concentrated hydrochloric acid (37%, 3.8 mL) was added slowly under stirring to form an acidic reaction system. The reaction system was stirred at 55 °C for 1.5 h. HPLC showed that the reaction was complete. The reaction system was cooled to room temperature and the pH was adjusted to 1.5 with aqueous sodium hydroxide solution and stirred for 30 min, during which (S)-2-amino-3-(4-boronic acid phenyl)propionic acid started to precipitate. Subsequently, the pH of the reaction system was re-adjusted to 6.2 with aqueous sodium hydroxide and stirring was continued overnight at room temperature. Upon completion of the reaction, the solid product was collected by filtration to afford (S)-2-amino-3-(4-boronic acid phenyl)propionic acid.

References

[1] Patent: EP2865682, 2015, A1. Location in patent: Paragraph 0077; 0078
[2] Patent: US2018/155368, 2018, A1. Location in patent: Paragraph 0123-0128
[3] Bulletin of the Chemical Society of Japan, 2000, vol. 73, # 1, p. 231 - 235

4-Borono-L-phenylalanine synthesis

Synthesis of 4-Borono-L-phenylalanine from (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

4-Borono-L-phenylalanine Preparation Products And Raw materials

Raw materials

L-Phenylalanine, 4-borono-N,N-bis(phenylmethyl)-, α-(phenylmethyl) ester (9CI) L-Phenylalanine, 4-borono-N-[(phenylmethoxy)carbonyl]- (9CI) Cbz-4-Iodo-L-Phenylalanine (S)-Benzyl 2-(benzyloxycarbonylamino)-3-(4-(trifluoromethylsulfonyloxy)phenyl)propanoate (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

Z-Tyr-OBzl (S)-4-(3-(Benzyloxy)-2-(benzyloxycarbonylamino)-3-oxopropyl)phenylboronic acid Water Hydrochloric acid Hydrogen

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Preparation Products

4-Borono-L-phenylalanine Suppliers

Global( 201)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Minruida Technology Co., Ltd.	010-82387566	sales@mreda.com.cn	China	19323	58
Vicbio Biotechnology Co., Ltd.	13621190864 13691409741	info@vicbio.com	China	13147	58
Xiamen Yunfan Biotech Co., Ltd.	0592-7828678 18050056030	357187337@qq.com	China	55	58
Shenyang Yetai Biotechnology Co., Ltd.	13555827137	378242599@qq.com	China	59	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	28-83379370 13880556291	tcy@tcypharm.com	China	509	57
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
Beijing Minruida Technology Co., Ltd.	58
Vicbio Biotechnology Co., Ltd.	58
Xiamen Yunfan Biotech Co., Ltd.	58
Shenyang Yetai Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Energy Chemical	61
Capot Chemical Co., Ltd	66
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	57
Adamas Reagent, Ltd.	59

View Lastest Price from 4-Borono-L-phenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-24	4-Borono-L-phenylalanine 76410-58-7			99.86%	10g	TargetMol Chemicals Inc.
2021-07-02	4-BORONO-L-PHENYLALANINE 76410-58-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-12-26	4-BORONO-L-PHENYLALANINE 76410-58-7	$1.00	1g	≥98%		Career Henan Chemical Co

4-Borono-L-phenylalanine
76410-58-7
$0.00
99.86%
TargetMol Chemicals Inc.

4-BORONO-L-PHENYLALANINE
76410-58-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-BORONO-L-PHENYLALANINE
76410-58-7
$1.00
≥98%
Career Henan Chemical Co

4-Borono-L-phenylalanine Spectrum

4-BORONO-L-PHENYLALANINE(76410-58-7)¹HNMR

76410-58-7(4-Borono-L-phenylalanine)Related Search:

Fmoc-D-3,4-dimethoxyphenylalanine 3,4-Dimethoxy-L-phenylalanine H-D-3,4-DMP-OH FMOC-3,4-DIMETHOXY-L-PHENYLALANINE BOC-3,4-DIMETHOXY-L-PHENYLALANINE

BOC-D-3,4-DIMETHOXYPHENYLALANINE L-4-Iodophenylalanine 2-Borono-L-phenylalanine 3-Borono-D-phenylalanine 2-Borono-D-phenylalanine

3-Borono-L-phenylalanine D-4-PHENYLALANINEBORONIC ACID,4-BORONO-D-PHENYLALANINE 97%,4-BORONO-D-PHENYLALANINE,4-BORONO-D-PHENYLALANINE B10 ENRICHED DL-4-PHENYLALANINEBORONIC ACID,4-BORONO-DL-PHENYLALANINE B10 ENRICHED,4-BORONO-DL-PHENYLALANINE (S)-BOC-4-BORONO-PHENYLALANINE FMOC-L-PHE(4-B(OH)2)-OH

4-BORONO-L-PHENYLALANINE

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(S)-(4-BORONIC ACID)-PHENYLALANINE 4-BORONO-L-PHENYLALANINE B10 ENRICHED L-PHE[B(OH)2] H-S-PHE(4-B(OH)2)-OH L-4-PHENYLALANINEBORONIC ACID 4-boronophenylalanine 4-L-BPA 4-dihydroxyboryl-l-phenylalanine 4-Dihydroxyboryl-L-phenylalanine, L-BPA 4-Borono-L-phenylalanine,97% 4-Borono-L-phenylalanine, L-4-Phenylalanineboronic acid L-4-(2-Amino-2-carboxyethyl)benzeneboronic acid 4-BORONO-L-PHENYLALANIN EOS-61315 L-Phenylalanine,4-borono- (S)-2-AMino-3-(4-boronophenyl)propanoic acid (2S)-2-aMino-3-[4-(dihydroxyboranyl)phenyl]propanoic acid 4-Borono-L-phenylalanine,99%+ 4-BORONO-L-PHENYLALANINE USP/EP/BP 4-Borono-L-phenylalanine, L-BPA 4-Borono-L-phenylalanine (contains varying amounts of Anhydride) (s)-2-amino-3-(4-boronophenyl)propanoic acid|||L-p-Boronophenylalanine Lisinopril Impurity 26 4-Borono-L-phenylalanine 4-Borono-L-phenylalanine - [B5003] L-p-Boronophenylalanine 4-Borono-L-phenylalanine 76410-58-7 Phenylalanine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Boronic Acids