Tcy-NH2
- CAS No.
- 327177-34-4
- Chemical Name:
- Tcy-NH2
- Synonyms
- Tcy-NH2;M.W. 739.87 C40H49N7O7;trans-Cinnamoyl-YPGKF-NH2;TRANS-CINNAMOYL-YPGKF-AMIDE;trans-Cinnamoyl-YPGKF-NH2, tcY-NH2;TRANS-CINNAMOYL-TYR-PRO-GLY-LYS-PHE-NH2;Protease-Activated Receptor-4, PAR-4 Antagonist, amide - 1 mg;trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt;L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl-
- CBNumber:
- CB4157102
- Molecular Formula:
- C40H49N7O7
- Molecular Weight:
- 739.86
- MDL Number:
- MFCD06798369
- MOL File:
- 327177-34-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|
Tcy-NH2 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 256892 | tcY-NH2 Asreported | 327177-34-4 | 1mg | $466 | 2026-06-03 | Buy |
| Biosynth | PAR-3675-PI | trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-NH2 | 327177-34-4 | 1mg | $150 | 2026-06-04 | Buy |
| Biosynth | PAR-3675-PI | trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-NH2 | 327177-34-4 | 5mg | $345.5 | 2026-06-04 | Buy |
| ChemScene | CS-0029155 | tcY-NH2 99.93% | 327177-34-4 | 1mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0029155 | tcY-NH2 99.93% | 327177-34-4 | 5mg | $282 | 2026-06-04 | Buy |
Tcy-NH2 Chemical Properties,Uses,Production
Uses
tcY-NH2 does not cause aggregation but blocks aggregation caused by receptor-activating peptide analogs (GY-NH2, AY-NH2), and thrombin without affecting ADP-mediated aggregation.
in vivo
tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model [4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice[6].
| Animal Model: | Brain death (BD) rat model[3] |
| Dosage: | 0.6 mg/kg for a single dose |
| Administration: | Tail vein injection for a single dose |
| Result: | Reduced blood platelet activation and hepatic platelet accumulation. Attenuated the inflammatory response and apoptosis in the livers. Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD). |
| Animal Model: | Burn injury model of C57BL/6 N mice[4] |
| Dosage: | 0.6 mg/kg for a single dose |
| Administration: | Intraperitoneal injection |
| Result: | Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis. |
| Animal Model: | BALB/c mice[6] |
| Dosage: | 40 ng/kg for a single dose |
| Administration: | Intrapleural injection |
| Result: | Abolished the number of rolling and adhering neutrophils on the vessel wall. Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice. |
IC 50
PAR4
storage
Store at -20°C
Tcy-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
Tcy-NH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Nanjing Yuanpeptide Biotech Co.，Ltd. | 13357818155 | linhui@yuan-peptide.com | China | 2901 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
